Gene Information

Name : Ththe16_0955 (Ththe16_0955)
Accession : YP_005640499.1
Strain : Thermus thermophilus SG0.5JP17-16
Genome accession: NC_017272
Putative virulence/resistance : Virulence
Product : 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Function : -
COG functional category : -
COG ID : -
EC number : 1.2.1.8
Position : 911642 - 913198 bp
Length : 1557 bp
Strand : +
Note : TIGRFAM: 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; KEGG: hpaE; 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; PFAM: Aldehyde dehydrogenase

DNA sequence :
ATGAGGTACGCCGACCAGGTTGCGGGCATCCCTTGGGAAACCATCGAGGCGGTGCGGCGGCGCCTAAAGGAAAAGCCCGC
CCTCCACTTCATCGCCGGGGAGTTTTCCCCTTCGGAAAGCGGGGAGACCTTCCCCTCCCTAGACCCCGCCACGAACGAGG
TCTTGGGCGTGGCGGCGAGGGGCGGGGAGAGGGAGGTGGACCGGGCGGCCAAGGCGGCCCACGAGGCCTTCCAGAGGTGG
AGCCGCACCAAGGCCAAGGAGAGGAAGCGCTACCTCCTCAAAATCGCCGAGCTCATAGAAAAACACGCCGACGAGCTTGC
CGTGATGGAGTGCCTGGACGCGGGGCAGGTCTTAAGGATCGTCCGGGCCCAGGTGGCCCGGGCGGCGGAAAACTTCGCCT
TCTACGCCGAGTACGCCGAGCACGCCATGGAGGATAGGACCTTCCCCGTGGACCGGGACTGGCTCTACTACACCGTCCGG
GTTCCCACGGGCCCCGTGGGGATCATCACCCCCTGGAACGCCCCCCTGATGCTCTCCACCTGGCGGATCGCCCCCGCCCT
GGCCTTTGGGAACACCGTGGTCCTGAAGCCCGCGGAGTGGAGCCCCTTCACCGCCAGCAAGCTTGCCGAGATCCTCCAGG
AGGCGGACCTCCCCCCTGGGGTCTTCAACCTGGTCCAGGGCTTTGGCGAGGAGGCGGGGGCGGCCCTGGTGGCCCACCCC
CTCGTCCCCCTCCTCACCCTCACCGGGGAGACGGAGACGGGGAAGATCGTCATGCGCAACGCCGCGGAGCACCTCAAGCG
CCTCTCCCCGGAGCTCGGCGGCAAAAGCCCCGCCCTGGTCTTCGCCGACGCCGATTTGGAGAGGGCCTTGGACGCCGTGG
TCTTCCAGATCTTCTCCTTCAACGGGGAAAGGTGCACGGCAAGCTCCAGGCTCCTCGTGGAGGAGAAGATCTTTGAGGAC
TTCGTGGGGCGGGTGGCGGAAAGGGCCCGGGCCATCCGGGTGGGCCACCCCCTGGACCCCGAGACGGAGGTGGGGCCCTT
GATCCACCCCGAGCACCTCCAGAGGGTCCTGGGCTACATCGAGGCGGGGAAGCAGGAAGGGGCGAGGCTCCTCGTGGGCG
GGGAGCGGGCCAAGACCTCCTTCCGGGGGGAGGACCTCTCCCGGGGGAACTACCTCCTCCCCACGGTTTTCGTGGGGGAG
AACCACATGAAAATCGCCCAAGAGGAGATCTTCGGGCCTGTCCTCGTGGCCATCCCTTTTAAGGACGAAGAGGACGCCCT
GAGGAAGGCGAACGACACCAAGTACGGCCTTGCCGCCTACGTCTTCACCCGTGACCTGGAAAGGGCCCACAGGCTTGCCC
TGGAATTGGAGGCAGGGATGGTCTACCTGAATAGCCACAACGTCCGCCACCTGCCCACCCCCTTCGGCGGGGTGAAGCAA
AGCGGGGACCGGCGGGAAGGGGGGTTTTACGCCCTGGACTTCTACACCGACCTCAAGACCATCGCCCTTCCCCTCCGTCC
CCCCCACGTGCCCAAGTTTGGAAAGGAAGGGAGGTAG

Protein sequence :
MRYADQVAGIPWETIEAVRRRLKEKPALHFIAGEFSPSESGETFPSLDPATNEVLGVAARGGEREVDRAAKAAHEAFQRW
SRTKAKERKRYLLKIAELIEKHADELAVMECLDAGQVLRIVRAQVARAAENFAFYAEYAEHAMEDRTFPVDRDWLYYTVR
VPTGPVGIITPWNAPLMLSTWRIAPALAFGNTVVLKPAEWSPFTASKLAEILQEADLPPGVFNLVQGFGEEAGAALVAHP
LVPLLTLTGETETGKIVMRNAAEHLKRLSPELGGKSPALVFADADLERALDAVVFQIFSFNGERCTASSRLLVEEKIFED
FVGRVAERARAIRVGHPLDPETEVGPLIHPEHLQRVLGYIEAGKQEGARLLVGGERAKTSFRGEDLSRGNYLLPTVFVGE
NHMKIAQEEIFGPVLVAIPFKDEEDALRKANDTKYGLAAYVFTRDLERAHRLALELEAGMVYLNSHNVRHLPTPFGGVKQ
SGDRREGGFYALDFYTDLKTIALPLRPPHVPKFGKEGR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hpaE AAO17179.1 HpaE Not tested tcd island Protein 6e-89 48
ORF SG19 AAN62241.1 putative aldehyde dehydrogenase Not tested PAGI-3(SG) Protein 4e-66 45
VC0819 NP_230467.2 aldehyde dehydrogenase Not tested VPI-1 Protein 4e-61 41
aldA AAC12273.1 aldehyde dehydrogenase Virulence VPI Protein 1e-62 41
aldA AAK20747.1 aldehyde dehydrogenase Virulence VPI Protein 1e-62 41
aldA AAK20776.1 aldehyde dehydrogenase Virulence VPI Protein 1e-62 41
aldA-1 YP_001216300.1 aldehyde dehydrogenase Not tested VPI-1 Protein 3e-62 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Ththe16_0955 YP_005640499.1 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase VFG0082 Protein 2e-61 41