Gene Information

Name : Ththe16_1607 (Ththe16_1607)
Accession : YP_005641130.1
Strain : Thermus thermophilus SG0.5JP17-16
Genome accession: NC_017272
Putative virulence/resistance : Resistance
Product : D-alanine--D-alanine ligase
Function : -
COG functional category : -
COG ID : -
EC number : 6.3.2.4
Position : 1541328 - 1542287 bp
Length : 960 bp
Strand : -
Note : PFAM: D-alanine--D-alanine ligase, C-terminal; D-alanine--D-alanine ligase, N-terminal; TIGRFAM: D-alanine--D-alanine ligase; HAMAP: D-alanine--D-alanine ligase; KEGG: ddl; D-alanine--D-alanine ligase

DNA sequence :
ATGAGGGTTCTTCTGATCGCCGGGGGCGTAAGCCCCGAGCACGAGGTCTCCCTCCTCTCCGCGGAAGGGGTTCTGCGCCA
CATGCCCTTCCCCACGGACCTCGCCGTGATCGCCCGGGACGGGCGCTGGCTTTTTGGGGAAAAGGCCTTGGCCGCCTTGG
AGGCCAAGGCGGCGCCCGAGGGGGAGCACCCCTTCCCCCCGCCCCTCCCCTGGGAGCGGTACGATGTGGTTTTTCCTCTC
CTCCACGGCCGCTTCGGCGAGGACGGGACGGTCCAGGGCTTTCTGGAGCTTTTGGGCAAGCCCTACGTGGGGGCGGGGGT
GACGGCGAGCGCCCTCTGCATGGACAAGGACCTGAGCAAGCGGGTCCTCGCCCAGGCGGGGGTGCCGGTGGTCCCCTGGG
TGGCGGTGCGGAAGGGCGAGCCCCCCATGGTGCCCTTTGACCCCCCCTTCTTCGTCAAGCCGGCCAACACCGGCTCCAGC
GTGGGGATAAGCCGGGTGGAACGCTTCCAGGACCTTGAGGCCGCCCTGGCCTTGGCCTTCCGCTACGATGAGAAGGCGGT
GGTGGAGAAGGCCCTCTCCCCGGTGCGGGAGCTTGAGGTGGGGGTTTTGGGCAACGTCTTCGGCGAGGCGAGCCCCGTGG
GGGAGGTGCGCTACGAGGCGCCCTTCTACGACTACGAGACCAAGTACACCCCGGGCCGGGCCGAGCTCCTCATCCCCGCG
CCCTTGGACCCCGGCACCCAGGAGACCGTTCAGGAGCTCGCCCTCAAGGCCTACAAGGTGCTCGGGGTGCGGGGGATGGC
CCGGGTGGACTTCTTCCTCGCGGAGGGGGAGCTTTACCTGAACGAGCTCAACACCATCCCCGGCTTCACCCCCACGAGCA
TGTACCCCCGCCTCTTTGAGGCGGGGGGGGTGGCCTACCCGGAGCTTCTCAGGCGCCTGGTGGAGCTCGCCCTCACCTAA

Protein sequence :
MRVLLIAGGVSPEHEVSLLSAEGVLRHMPFPTDLAVIARDGRWLFGEKALAALEAKAAPEGEHPFPPPLPWERYDVVFPL
LHGRFGEDGTVQGFLELLGKPYVGAGVTASALCMDKDLSKRVLAQAGVPVVPWVAVRKGEPPMVPFDPPFFVKPANTGSS
VGISRVERFQDLEAALALAFRYDEKAVVEKALSPVRELEVGVLGNVFGEASPVGEVRYEAPFYDYETKYTPGRAELLIPA
PLDPGTQETVQELALKAYKVLGVRGMARVDFFLAEGELYLNELNTIPGFTPTSMYPRLFEAGGVAYPELLRRLVELALT

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
vanB YP_008394259.1 Vancomycin B-type resistance protein vanB, D-alanine--D-lactate ligase Not tested Not named Protein 4e-34 41
vanB NP_815951.1 D-alanine--D-lactate ligase Not tested Not named Protein 7e-34 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Ththe16_1607 YP_005641130.1 D-alanine--D-alanine ligase NC_014475.1.orf3.gen Protein 2e-33 42
Ththe16_1607 YP_005641130.1 D-alanine--D-alanine ligase NC_005054.2598280.p0 Protein 2e-33 42
Ththe16_1607 YP_005641130.1 D-alanine--D-alanine ligase AY489045.gene.p01 Protein 2e-35 42
Ththe16_1607 YP_005641130.1 D-alanine--D-alanine ligase AF277571.gene.p01 Protein 2e-36 42
Ththe16_1607 YP_005641130.1 D-alanine--D-alanine ligase AF310956.2.orf5.gene Protein 3e-33 41
Ththe16_1607 YP_005641130.1 D-alanine--D-alanine ligase AY145441.gene.p01 Protein 1e-33 41
Ththe16_1607 YP_005641130.1 D-alanine--D-alanine ligase U35369.1.gene6.p01 Protein 3e-34 41
Ththe16_1607 YP_005641130.1 D-alanine--D-alanine ligase AE016830.1.gene2250. Protein 3e-34 41
Ththe16_1607 YP_005641130.1 D-alanine--D-alanine ligase U00456.gene.p01 Protein 3e-34 41
Ththe16_1607 YP_005641130.1 D-alanine--D-alanine ligase AF130997.1.orf4.gene Protein 3e-36 41