Gene Information

Name : Ththe16_1165 (Ththe16_1165)
Accession : YP_005640701.1
Strain : Thermus thermophilus SG0.5JP17-16
Genome accession: NC_017272
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : -
COG ID : -
EC number : 1.16.1.1
Position : 1122215 - 1123588 bp
Length : 1374 bp
Strand : -
Note : TIGRFAM: Mercuric reductase MerA; KEGG: msv:Mesil_1148 mercuric reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation

DNA sequence :
ATGACCTACGACCTCCTCATCGTAGGCTCGGGCTCCGCCGGGGTGGCGGCGGCCCTGGAGGCGAGCGCCCTCGGGGCCAA
GGCGGCCGTGGTGGAGGCGGGGGTTTTGGGGGGGACCTGCGTCAACGTGGGGTGCGTGCCCTCCAAGTACCTCCTCCGGG
CGGCCGACGCCTTTCACCGGGCGGGCCACTCCGCCTTCCCCGGCCTCCGCACGGAGGCCCTGGGGGTGGACTGGAAAGCC
CTCCTCGCGGGCAAGGAGGGCCTGATCGCGGCCCTCAGGAAGGAGAAGTACCAGGAGGTCCTGGAGGCGGCCGGGGTTCC
CGTGCTCCGGGGGAGGGCCCGCTTCCTGGACGGGGAAAGGATGGAGGTAGAGGGGCGGGAGGTCTTGGCTGGGCGGTACC
TCCTCGCCACCGGGGCGAGGCCCTTCCTTCCGCCCATCCCCGGCCTCCAGGAGAGCGCGCCCTGGACCTACCTCGAGGCC
CTCTCCGCCCCCGCCCTTCCCGAAAGCCTCCTGGTGGTGGGGGGTGGGCCCATCGGGCTTGAGCTCGCCCAGGCCTTCGC
CAGGCTTGGGAGCCGGGTGACGGTCCTCGAGGCCCTGCCCGAGGTCCTGCCCCAGGAGGACCGGGAGCTTGCCCAGCTCC
TCCGGGGCTACCTGGAGGAGGAGGGCCTTAGGGTCCACACCGGGGTCCGGGTGGAGGCGGTGGTCCGGGAAGGGGCCTTC
CGCGTCCGGACCGACCGGGGGGTTTTTGAGGCGGAGAGGCTCCTCGTGGCCACGGGGAGGAGGCCCAACCTTGAGGGGCT
CGGCCTGGAGCGGGCAGGCGTGGAGCGGGACGAGCGGGGCTTCCTTCGGCTGGACCCGAGCCTGCGCACCACCAACCCCC
GGGTCTACGCCGCCGGGGACGCGGCGGGGCTTCCCCAGTTCGTCTACGTGGCCGCCCAGTCGGGCCGGGTGGCGGCCCGC
AACGCCTTGGGGGTGGAGACGCCCCTGGACCTCGCCGCCCTCCCCCGGGTCACCTTCACCGACCCCGCCCTGGCCGCGGT
GGGCCTCACGGAGGAGGAGGCGAGGAGGCGGTACGGCGCGGGGGTGCGGGCGGCCACCCTTCCCCTTTCCCAGGTGCCCA
AGGCCCTCACCGCCCGCGATGCCCGGGGGGCCTTCAAGATCGTGGTGGACGAAGAGGGCACGGTCCTCGGCCTCCACGTC
CTGGCCCACGAGGCGGGGGACGTCATCCAGGAGGGCATCCTGGCGGTGAAGTACGGCCTCGGCTACCGGGACCTCATAGA
CACCTTCTACCCCTACCTGACCCTGGCCGAGGGGATAAGGCTCGTGGCCCAGGCCCTGGACGCCGATCCCAAAAAGCTTT
CCTGCTGCGCCTGA

Protein sequence :
MTYDLLIVGSGSAGVAAALEASALGAKAAVVEAGVLGGTCVNVGCVPSKYLLRAADAFHRAGHSAFPGLRTEALGVDWKA
LLAGKEGLIAALRKEKYQEVLEAAGVPVLRGRARFLDGERMEVEGREVLAGRYLLATGARPFLPPIPGLQESAPWTYLEA
LSAPALPESLLVVGGGPIGLELAQAFARLGSRVTVLEALPEVLPQEDRELAQLLRGYLEEEGLRVHTGVRVEAVVREGAF
RVRTDRGVFEAERLLVATGRRPNLEGLGLERAGVERDERGFLRLDPSLRTTNPRVYAAGDAAGLPQFVYVAAQSGRVAAR
NALGVETPLDLAALPRVTFTDPALAAVGLTEEEARRRYGAGVRAATLPLSQVPKALTARDARGAFKIVVDEEGTVLGLHV
LAHEAGDVIQEGILAVKYGLGYRDLIDTFYPYLTLAEGIRLVAQALDADPKKLSCCA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 3e-64 44
merA AGK07021.1 MerA Not tested SGI1 Protein 6e-66 43
merA AGK07079.1 MerA Not tested SGI1 Protein 6e-66 43
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 8e-65 43
merA ABQ57371.1 MerA Not tested SGI1 Protein 6e-66 43
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 1e-64 43
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 1e-64 43
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 1e-64 42
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 8e-65 42
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 5e-64 42
merA AFG30120.1 MerA Not tested PAGI-2 Protein 5e-64 42
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 6e-64 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Ththe16_1165 YP_005640701.1 mercuric reductase BAC0652 Protein 2e-66 43
Ththe16_1165 YP_005640701.1 mercuric reductase BAC0653 Protein 2e-64 43
Ththe16_1165 YP_005640701.1 mercuric reductase BAC0651 Protein 5e-65 42
Ththe16_1165 YP_005640701.1 mercuric reductase BAC0650 Protein 9e-62 42