Gene Information

Name : clpB (TPChic_0071)
Accession : YP_005630980.1
Strain : Treponema pallidum Chicago
Genome accession: NC_017268
Putative virulence/resistance : Virulence
Product : ATP-dependent chaperone protein ClpB
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 75917 - 78553 bp
Length : 2637 bp
Strand : -
Note : identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; match to protein family HMM TIGR03346

DNA sequence :
ATGAACACAGACAGGTACACAGTCAAAGCAAGCGAAGCGCTCAATGACGCCATATCTCTGGCAGAAGCGGAGAACCACGG
TCAAGTTGAGGAGGAACATCTACTCCACGCCCTACTTTCCCAGAAAGACGGGATTATCTCTCCGCTCATTGAAAAAATTG
GGGCAAAACCGGACTTCCTGTACGATGAATTACTCCAATGCCTGCGCCGCAAACCACGTGTTACCGGTCCTGCCGCCCAA
ACGCGCTGTGCACCAACGCTGAGCAAAGCCTGTGCACGTGCAGAACGCCTCGCGCTCAAGAACCAAGATGAATATGTCTC
CTGCGAACATCTCCTGCTTGCCATAAGTGAGACAGATAGCAACACTGCACGTCTCCTTCACAGTCAGGGCATTACCAGTA
AAACTATCAGTGCCGCCCTCAAAGATATACGCGGCAGCAAGCGCGTTACGAGCCAGGATCCAGAATCAACATTCCAGTGC
TTGGAGAAATACTGCCGAGATCTTACTACCCTCGCCCGAGAAGAAAAAATAGATCCGGTTATTGGACGTGATGAAGAGAT
CCGGCGCGTTATGCAGGTACTCTCACGTCGTACAAAAAATAACCCAGTGCTTATTGGAGAACCCGGCGTAGGGAAAACCG
CTATTGTCGAGGGACTTGCACGCCGTATCGTTTCAGGAGACGTACCAGAAAGCCTCAAGGGAAAGCGTTTGCTTTCCCTT
GACCTCGGCGCATTGGTTGCCGGTGCAAAGTTCCGCGGGGAATTTGAAGAACGACTAAAAGCGGTAATTGAAGCGGTACA
GAAAAGCGACGGTGGCGTTATTTTATTCATTGATGAACTACACACGCTCGTAGGCGCCGGCGCAAGTGAGGGATCTATGG
ATGCGTCGAACCTTCTGAAACCTGCGCTTGCGCGCGGTGAATTGCGTTCAATCGGCGCAACCACGCTCAACGAATATCGC
AAATATATCGAAAAGGACGCAGCGCTCGAACGCCGCTTTCAGCAAGTGTACTGCGTACAGCCTACGGTGGAGGACACCAT
TGCTATCCTGCGCGGTTTGCAAGAAAAGTACGAAGTGCATCACGGGGTACGTATCAAAGATGAAGCGCTTGTTGCAGCAA
CCGTTTTGTCTGACCGTTACATCACCAACCGCTTTTTACCAGATAAGGCGATTGATCTGGTGGATGAAGCAGCAAGCCGC
CTGAAAATGGAAATTGAAAGTCAGCCTGTTGAGCTAGACCAGGTGGAGCGCAAGATATTACAGCTGAATATCGAAAAGGC
CTCTCTCCTTAAAGAAAGTGATCCGGCTTCAAAGGAACGTTTGGAAAAGTTAGAAAAAGAGCTCGCAGGCTTCCTAGAGC
GCCGTGCTGCAATGCAGGTCCAATGGCAAAATGAGAAAGGGAGGATAGAAGAGTCACGCCGCTACAAAGAGGAGCTTGAG
CGTCTCCGCATTGAGGAAACCATGTTTTCACGTGAAGGGGACCTGAACAAGGCTGCAGAACTTCGGTATGGCAAAATTCC
AGAACTTGAAAAAAAAATCATGCTTCTTACTGCAGAAGTAGAGAAAAAATCCGGTCTAGAAGGACAGCTCTTGCGCGAGG
AAGTGTGTGAAGAGGACATTGCGAAAATTATTTCTATGTGGACCGGAATTCCGGTATCCAAAATGATGGCAAGCGAGCAA
CAGAAATATCTGCAGCTTGAGTCAGTACTCATGCAACGTGTGGTAGGGCAGGACGAAGCAGTGCGGGTAATTTCCGACGC
GATTCGTCGTAATAAGGCAGGACTTTCTGATACGCGCCGTCCTCTTGGCAGTTTCTTATGTGTCGGTCCCACGGGGGTAG
GAAAGACAGAACTTGCACGTACGTTAGCTGATTTTCTTTTCAACGATGAGCGTGCACTGACGCGTATCGATATGAGTGAA
TACATGGAAAAACACGCGATCAGCCGACTCATTGGCGCGCCCCCGGGGTATGTGGGCTATGACGAGGGGGGACAATTGAC
AGAAGCGGTACGACGTAGACCCTACAGCGTACTTCTTTTTGATGAAGTAGAGAAAGCGCACCAGGATGTGTTTAATATAT
TCCTGCAAATACTCGACGATGGGCGCTTGACTGACGGCCAAGGAAGGGTGGTGGATTTCCGCAACACGATCATCATCATG
ACCAGCAATATCGGATCAGAGCATATTCTTTCTGCACGCGAGTCGCGCACACACACGTCGGACTTGCCTGTACCCGAGAC
ACAATCTACAGAAGAACAAACTCTACCAGAGCAGATACGGGGATTACTGCACACATACTTTCGCCCAGAATTCTTAAACC
GGATTGACGAAGTGTTAATTTTTAAGCGTCTCACACGGAAACATATTCGCCTCATCACAGACATCCAACTGCAGATGGTA
GTGGAGCGTTTGGAAAGTCGACATATAAAACTTCGTGTGCGTGACGCGGCGAAAGCCTATCTTGCGGAGCGCGGATACGA
CGACACTTTCGGAGCACGACCACTGAAGCGTGCAATCCAAACGGAATTGGAAAATGCCCTAGCGCGTGAGATTCTCAGTG
GCCGATTCAGAGGCGGCTCAACTATCGTGGTGGATATGTGTAAAGATGCTCTGTGTTTCACTGAACAAACATCCTGA

Protein sequence :
MNTDRYTVKASEALNDAISLAEAENHGQVEEEHLLHALLSQKDGIISPLIEKIGAKPDFLYDELLQCLRRKPRVTGPAAQ
TRCAPTLSKACARAERLALKNQDEYVSCEHLLLAISETDSNTARLLHSQGITSKTISAALKDIRGSKRVTSQDPESTFQC
LEKYCRDLTTLAREEKIDPVIGRDEEIRRVMQVLSRRTKNNPVLIGEPGVGKTAIVEGLARRIVSGDVPESLKGKRLLSL
DLGALVAGAKFRGEFEERLKAVIEAVQKSDGGVILFIDELHTLVGAGASEGSMDASNLLKPALARGELRSIGATTLNEYR
KYIEKDAALERRFQQVYCVQPTVEDTIAILRGLQEKYEVHHGVRIKDEALVAATVLSDRYITNRFLPDKAIDLVDEAASR
LKMEIESQPVELDQVERKILQLNIEKASLLKESDPASKERLEKLEKELAGFLERRAAMQVQWQNEKGRIEESRRYKEELE
RLRIEETMFSREGDLNKAAELRYGKIPELEKKIMLLTAEVEKKSGLEGQLLREEVCEEDIAKIISMWTGIPVSKMMASEQ
QKYLQLESVLMQRVVGQDEAVRVISDAIRRNKAGLSDTRRPLGSFLCVGPTGVGKTELARTLADFLFNDERALTRIDMSE
YMEKHAISRLIGAPPGYVGYDEGGQLTEAVRRRPYSVLLFDEVEKAHQDVFNIFLQILDDGRLTDGQGRVVDFRNTIIIM
TSNIGSEHILSARESRTHTSDLPVPETQSTEEQTLPEQIRGLLHTYFRPEFLNRIDEVLIFKRLTRKHIRLITDIQLQMV
VERLESRHIKLRVRDAAKAYLAERGYDDTFGARPLKRAIQTELENALAREILSGRFRGGSTIVVDMCKDALCFTEQTS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 4e-106 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpB YP_005630980.1 ATP-dependent chaperone protein ClpB VFG2084 Protein 8e-103 43
clpB YP_005630980.1 ATP-dependent chaperone protein ClpB VFG2076 Protein 7e-112 41