Gene Information

Name : bcrD (BPTD_2222)
Accession : YP_005590294.1
Strain : Bordetella pertussis CS
Genome accession: NC_017223
Putative virulence/resistance : Virulence
Product : putative type III secretion pore protein
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 2406354 - 2408453 bp
Length : 2100 bp
Strand : +
Note : -

DNA sequence :
ATGACGAGCAAGAAATCCATTCGCCGCCTGCAACGCGCGGTGGCGCTGGCCACCAGCCGCAACGACATCGTACTGGCCGT
GCTCATCGTGGCGATCGTCTTCATGATGATCCTGCCGTTGCCCACAACGCTGGTCGACGTGCTGATCGGTGCGAACATGA
CGCTGTCGGCAGTCCTGCTGATGGTCGCGATGTACCTGCCTTCGCCCCTGGCGTTTTCCTCGTTCCCTTCGGTCCTGCTG
GTCACCACGCTGTTCCGGCTGGGCATCTCCATCGCGACCACGCGGCTGATCCTGCTGCAAGGCGATGCCGGCCACATCAT
CGAGACCTTCGGCAACTTCGTGGTGGGCGGCAACCTGATCGTCGGCCTGGTGGTTTTCCTCATCCTCACGATCGTGCAGT
TCGTGGTCATCACCAAAGGCGCGGAGCGGGTGGCCGAAGTCGCCGCGCGCTTCTCGCTGGACGCCATGCCCGGCAAGCAG
ATGTCCATCGACGCGGACTTGCGCGCGGGCACCATAGACATGGACGAAGCCCGACGCCGACGCCGTACGGTCGAGAAGGA
AAGCCAACTGTATGGCGCCATGGACGGCGCGATGAAGTTCGTCAAGGGCGATGCCATCGCCGGCCTGATCATCGTTGCCG
TCAACCTGCTTGGCGGCATGCTGGTCGGCGTGCTGCAGCGCGGCCTGAGCGCCGGCGAGGCCGTGCAGACATATGCCATC
CTGACCATAGGCGACGGGCTCATCGCGCAGATCCCGGCGCTGTTCATCGCCATCTGCGCCGGAATCATCGTGACGCGGGT
GCAGACCGGGGATGGCCCCTCCAACGTAGGCACCGACATCGGCGCACAAGTGCTGGCGCAGCCTCGCGCCCTGGTCATTG
CCGGCGCGATCTCGGCAGGCCTGGGCCTCATTCCCGGCATGCCCACGCTGGTCTTCTTCGCCCTGGCCGCCGCGGTGGGC
ACCATCGGTTTCGTACTGCTGCGCGCATCCCAGCGTCCGCCCGAAGGCGCCGAGCCCGCGCTCGCCGGCATGGCTGCCGA
CGGCCAGCCCCGCACCCGCGCGCCGGCGGATGGGCAGGCGGAATTCGCCCCCACCGTCCCGCTGATCATCGACGTAGCCG
CGCGGCTGCAGCCCCGGTTCGAGCCGGCCACCCTCACCGACGATCTGCTGCAGATCCGGCGGGCGCTCTATTTCGACCTG
GGCGTGCCGTTTCCCGGCATCCAGTTGCGCTTCACCGAAGCGCTGGCCGCCAATACCTACACCATCGTGCTGTCGGAGAT
CCCGGTGGCGCAAGGAATGTTGCGCGACGATGCCGTGCTGGTGCGGGACACCGAGCAGAACCTGCAGGCCCTGCGGATCG
CATACGAAACGGGCGCGGCCTTTCTGCCCGATACGCCCACGATCTGGGTTGCGGCCAGTCTGACCGGCGCCTTGCGCGAT
GCAGGTATTCCTTACCTGGGTATCAGCCAGATCCTGACTTGGCACTTGGCATATGTATTGAAAAAATATTCAGCCGATTT
CATCGGCATCCAGGAAACCCGGTTTCTGCTTTCGGCCATGGAAGAACGATTTCCCGATCTGGTCAAGGAGTGCCTGCGCG
TCATGCCGGTGCAGAAGATTGCCGAAATCCTGCAGCGCCTTGTTTCCGAAGAAGTGTCGATACGCAACCTGCGCGCCGTC
CTGGAAGCGCTGGTCGAATGGGGCCAGAAGGAAAAGGATACCGTCCTGCTTACGGAGTATGTCCGAATCGCACTCAAGCG
CTATATCAGCCACAAGTACACCAGCGGCCACAATATCCTGCCCGCCTACCTGCTGGCCCCCAAGGTCGAGGAAACCGTGC
GCGCCGCCATCCGGCAGACCGCCGCCGGCAGTTATCTCGCCCTCGATCCGGACACGACACGCCGACTGGTCGAGCACATC
CGTCAATGTGTCGGCGATCTGGCCGCCGGCGCGAGCCGTCCCGTCTTGCTGACGTCGATGGACATCCGGCGCTACACGCG
CAAGATGATAGAAGCCGATCTCTACGCCCTGCCGGTGCTGTCCTACCAGGAACTGACGCCGGAGATCAATGTACAGCCCC
TGGGCAGGGTGGATCTATGA

Protein sequence :
MTSKKSIRRLQRAVALATSRNDIVLAVLIVAIVFMMILPLPTTLVDVLIGANMTLSAVLLMVAMYLPSPLAFSSFPSVLL
VTTLFRLGISIATTRLILLQGDAGHIIETFGNFVVGGNLIVGLVVFLILTIVQFVVITKGAERVAEVAARFSLDAMPGKQ
MSIDADLRAGTIDMDEARRRRRTVEKESQLYGAMDGAMKFVKGDAIAGLIIVAVNLLGGMLVGVLQRGLSAGEAVQTYAI
LTIGDGLIAQIPALFIAICAGIIVTRVQTGDGPSNVGTDIGAQVLAQPRALVIAGAISAGLGLIPGMPTLVFFALAAAVG
TIGFVLLRASQRPPEGAEPALAGMAADGQPRTRAPADGQAEFAPTVPLIIDVAARLQPRFEPATLTDDLLQIRRALYFDL
GVPFPGIQLRFTEALAANTYTIVLSEIPVAQGMLRDDAVLVRDTEQNLQALRIAYETGAAFLPDTPTIWVAASLTGALRD
AGIPYLGISQILTWHLAYVLKKYSADFIGIQETRFLLSAMEERFPDLVKECLRVMPVQKIAEILQRLVSEEVSIRNLRAV
LEALVEWGQKEKDTVLLTEYVRIALKRYISHKYTSGHNILPAYLLAPKVEETVRAAIRQTAAGSYLALDPDTTRRLVEHI
RQCVGDLAAGASRPVLLTSMDIRRYTRKMIEADLYALPVLSYQELTPEINVQPLGRVDL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
lssD AAO18050.1 LssD Virulence TTSS locus Protein 1e-179 59
YPO0266 YP_002345347.1 secretion system apparatus protein SsaV Virulence Not named Protein 4e-117 48
hrcV AAT96256.1 HrcV Virulence S-PAI Protein 2e-99 46
hrcV AAT96297.1 HrcV Virulence S-PAI Protein 5e-99 46
hrcV AAT96337.1 HrcV Virulence S-PAI Protein 2e-99 46
hrcV ABA47273.1 HrcV Virulence S-PAI Protein 6e-96 46
hrcV NP_636603.1 protein HrcV Virulence Hrp PAI Protein 5e-101 45
hrcV YP_362156.1 HrcV protein Virulence Hrp PAI Protein 6e-98 45
hrcV AAP34346.1 HrcV Virulence Hrp PAI Protein 6e-96 45
XC_3013 YP_244081.1 HrcV protein Virulence Hrp PAI Protein 5e-101 45
hrcV NP_640760.1 HrcV protein Virulence Hrp PAI Protein 5e-96 45
hrcV BAB07859.1 HrcV Virulence Hrp PAI Protein 4e-97 44
hrcV YP_198723.1 protein HrcV Virulence Hrp PAI Protein 6e-97 44
ssaV CAA70536.1 secretion system apparatus Virulence SPI-2 Protein 9e-101 43
ssaV NP_456114.1 putative type III secretion protein Virulence SPI-2 Protein 3e-100 43
ssaV NP_805085.1 secretion system apparatus protein SsaV Virulence SPI-2 Protein 3e-100 43
ssaV YP_216422.1 secretion system apparatus protein SsaV Virulence SPI-2 Protein 1e-100 43
ssaV NP_460379.1 secretion system apparatus protein SsaV Virulence SPI-2 Protein 1e-100 43
invA AAS66860.1 InvA Not tested SSR-2 Protein 1e-91 43
hrcV AAB05999.2 HrcV Virulence Hrp PAI Protein 2e-100 43
hrcV AAR25631.1 type III secretion protein HrcV Not tested Not named Protein 2e-93 43
invA NP_457290.1 possible secretory protein (associated with virulence) Virulence SPI-1 Protein 2e-99 43
invA NP_806499.1 virulence-associated secretory protein Virulence SPI-1 Protein 2e-99 43
invA NP_461817.1 needle complex export protein Virulence SPI-1 Protein 2e-99 43
invA YP_217815.1 invasion protein Virulence SPI-1 Protein 2e-99 43
hrcV ABQ88352.1 HrcV Virulence Hrp PAI Protein 7e-98 43
hrpI AAA03015.1 HrpI Virulence Hrp PAI Protein 7e-98 43
hrcV NP_791229.1 type III secretion protein HrcV Virulence Hrp PAI Protein 7e-96 43
hrcV AAG33877.1 HrcV Virulence Hrp PAI Protein 8e-96 43
hrcV AAT96139.1 HrcV Virulence T-PAI Protein 1e-98 42
hrcV AAT96193.1 HrcV Virulence T-PAI Protein 1e-98 42
escV YP_003236089.1 putative translocator EscV Virulence LEE Protein 1e-97 42
escV CAC81861.1 EscV protein Virulence LEE II Protein 2e-98 42
escV CAI43875.1 EscV protein Virulence LEE Protein 1e-98 42
escV NP_290269.1 hypothetical protein Virulence LEE Protein 4e-98 42
ECs4569 NP_312596.1 hypothetical protein Virulence LEE Protein 4e-98 42
escV AAK26714.1 EscV Virulence LEE Protein 1e-98 42
escV YP_003223476.1 translocator EscV Virulence LEE Protein 2e-98 42
escV AAL57541.1 EscV Virulence LEE Protein 1e-98 42
escV YP_003232152.1 T3SS structure protein EscV Virulence LEE Protein 2e-98 42
escV AAC38382.1 EscV Virulence LEE Protein 7e-99 42
escV AAC31514.1 L0035 Virulence LEE Protein 3e-98 42
escV ACU09459.1 EscV protein Virulence LEE Protein 3e-98 42
unnamed AAL06368.1 EscV Virulence LEE Protein 6e-98 42
escV AFO66414.1 putative LEE-encoded type III secretion system factor Virulence SESS LEE Protein 1e-93 42
escV AFO66296.1 putative LEE-encoded type III secretion system factor Virulence SESS LEE Protein 1e-93 42
ECs3731 NP_311758.1 EivA Not tested LIM Protein 4e-99 42
ysaV AAS66840.1 YsaV Not tested SSR-1 Protein 5e-98 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
bcrD YP_005590294.1 putative type III secretion pore protein VFG0064 Protein 0.0 100
bcrD YP_005590294.1 putative type III secretion pore protein VFG0198 Protein 1e-165 59
bcrD YP_005590294.1 putative type III secretion pore protein VFG0384 Protein 4e-176 59
bcrD YP_005590294.1 putative type III secretion pore protein VFG2126 Protein 3e-128 47
bcrD YP_005590294.1 putative type III secretion pore protein VFG0514 Protein 5e-101 43
bcrD YP_005590294.1 putative type III secretion pore protein VFG2461 Protein 2e-98 43
bcrD YP_005590294.1 putative type III secretion pore protein VFG0557 Protein 9e-100 43
bcrD YP_005590294.1 putative type III secretion pore protein VFG0813 Protein 2e-98 42
bcrD YP_005590294.1 putative type III secretion pore protein VFG0729 Protein 4e-99 42
bcrD YP_005590294.1 putative type III secretion pore protein VFG1780 Protein 6e-97 41
bcrD YP_005590294.1 putative type III secretion pore protein VFG1006 Protein 3e-94 41