Gene Information

Name : vanB (RAM_42565)
Accession : YP_005536437.1
Strain : Amycolatopsis mediterranei S699
Genome accession: NC_017186
Putative virulence/resistance : Resistance
Product : D-alanine--D-lactate ligase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 9115558 - 9116586 bp
Length : 1029 bp
Strand : -
Note : COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes

DNA sequence :
ATGAATAGGCTCAAGGTCGGGATCATCTTCGGGGGCGCCTCCGAGGAACACCCCGTCTCGGTGAAATCCGCGCAAGAGGT
CGCGCGGCACCTCGACACCGGGAAGTACGAACCGTTCTGGATCGGGATCACGAAGGACGGCGCCTGGAAACTCGGTGACG
GCCCGGGCGAAAGCTGGGAAGCCGGGCGGACGGTCGTGCTGTCGCCGGACCGGAGCGTGCCGGGCTTGCTGGTCCTCGAA
GACGGCAAGTACGAGACGATCGGCCTGGACGTGGTGCTGCCCGTGCTGCACGGCAAGCTCGGCGAGGACGGCGCGATGCA
GGGCCTGCTGGAGCTTTCCGGGATCCCGTACGCGGGCTGCGACGTCCCGAGTTCCGCGCTGTGCATGGACAAATCCCTCG
CTTACGTCGTCGCCGCGAGCGCGGGCATCGCGACGCCGAAATTCCGGACCGTCCTGGCGGGCGACGACGCCGGCGCGTTC
ACCTATCCCGTCTTCGTGAAGCCGGCGCGCTCGGGTTCTTCCTTCGGCGTCAGCAAGGTTTCCGGCCGGGAAGAACTGGC
CGCCGCGATCAGCACCGCGGCGCAGTACGACGCGAAGGTGCTGATCGAAGAGGCCGTCGTCGGCAGCGAGGTCGGGTGCG
CCGTTCTGGGGAACGGCCGCGAGCTGTTCGCCGGAGAGGTCGACCGGATCGCCCTCTCCCACGGCTTTTTCCGGATCCAC
CAGGAAGAGCAGCCCGAAAGCGGCTCCGAGAACTCGACGCCCATCGTGCCCGCCGACGTTCCGGCAGAGACCCGGGCGCG
AGTCCAGCAGACGGCGAAGGCCATCTACCGCGCTCTGGGATGCAAAGGGCTGGCACGGGTCGACATGTTCCTCACCGACG
ACGGCACGGTGGTCCTCAACGAGGTCAACACCCTGCCCGGCTTGACGTCGTACAGCCGCTACCCCCGGATGATGGCGGCC
GCCGGCGTGCCGCTGTCCGCGCTGATCGACCGGCTCGTTTCCCTGGCCATGACCGGGGCCGCCCGGTGA

Protein sequence :
MNRLKVGIIFGGASEEHPVSVKSAQEVARHLDTGKYEPFWIGITKDGAWKLGDGPGESWEAGRTVVLSPDRSVPGLLVLE
DGKYETIGLDVVLPVLHGKLGEDGAMQGLLELSGIPYAGCDVPSSALCMDKSLAYVVAASAGIATPKFRTVLAGDDAGAF
TYPVFVKPARSGSSFGVSKVSGREELAAAISTAAQYDAKVLIEEAVVGSEVGCAVLGNGRELFAGEVDRIALSHGFFRIH
QEEQPESGSENSTPIVPADVPAETRARVQQTAKAIYRALGCKGLARVDMFLTDDGTVVLNEVNTLPGLTSYSRYPRMMAA
AGVPLSALIDRLVSLAMTGAAR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
vanB YP_008394259.1 Vancomycin B-type resistance protein vanB, D-alanine--D-lactate ligase Not tested Not named Protein 2e-103 66
vanB NP_815951.1 D-alanine--D-lactate ligase Not tested Not named Protein 1e-101 65

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
vanB YP_005536437.1 D-alanine--D-lactate ligase AF310956.2.orf5.gene Protein 1e-103 66
vanB YP_005536437.1 D-alanine--D-lactate ligase AY145441.gene.p01 Protein 1e-103 66
vanB YP_005536437.1 D-alanine--D-lactate ligase U35369.1.gene6.p01 Protein 5e-102 65
vanB YP_005536437.1 D-alanine--D-lactate ligase AE016830.1.gene2250. Protein 5e-102 65
vanB YP_005536437.1 D-alanine--D-lactate ligase U00456.gene.p01 Protein 5e-102 65
vanB YP_005536437.1 D-alanine--D-lactate ligase AF277571.gene.p01 Protein 1e-103 64
vanB YP_005536437.1 D-alanine--D-lactate ligase NC_014475.1.orf3.gen Protein 2e-99 63
vanB YP_005536437.1 D-alanine--D-lactate ligase NC_005054.2598280.p0 Protein 2e-99 63
vanB YP_005536437.1 D-alanine--D-lactate ligase AF130997.1.orf4.gene Protein 2e-101 63
vanB YP_005536437.1 D-alanine--D-lactate ligase AY489045.gene.p01 Protein 2e-100 63