Gene Information

Name : merA (MARHY1938)
Accession : YP_005429838.1
Strain : Marinobacter hydrocarbonoclasticus ATCC 49840
Genome accession: NC_017067
Putative virulence/resistance : Resistance
Product : Mercuric reductase (Hg(II) reductase)
Function : -
COG functional category : -
COG ID : -
EC number : 1.16.1.1
Position : 1997421 - 1998827 bp
Length : 1407 bp
Strand : -
Note : Evidence 2b : Function of strongly homologous gene; PubMedId : 6311258, 6412751; Product type e : enzyme

DNA sequence : 
GTGAAAAATGACAACAAACTGCATATTGCGGTAATCGGCAGTGGTGGTGCCGCCATGGCGGCTGCCCTGAAGGCAACAGA
GCGCGGTGCCCGCGTCACCCTGATTGAACGTGGGACTGTCGGCGGCACCTGCGTAAATGTTGGCTGCGTGCCCTCGAAGA
TTATGATTCGTGCAGCACATATCGCGCACCTGCGAAAAGAAAGCCCGTTTGACGCGGGCATCAGTGCTGAGGCTCCTCAG
GTAGACCGAGCAAAACTGCTTCAGCAACAGCAGGCACGAGTGGAGGAGCTGCGTGACACCAAGTACGAAAAGATACTTCG
AGAACACAAGGACATCACAGTCCTGAACGGTGAGGCCCGGTTTGTCGATACCAATAGCCTGGTAGTCACGCTGGCTGAGG
GTGGTGAAAAACCGGTTCATTTTGATCGCGCCTTTATTGGAACCGGAGCCAGACCGGCAGAGCCGCCAATAACGGGGCTG
GCAGACACTCCTTACCTGACATCAACCAGTGCCTTGGCGCTGGATACCGTTCCCAAACGGCTGATCGTGATTGGTGCCGG
TTTCGTTTCCTTGGAATTGGCTCAGGCATTCGACAGACTCGGCAGCAAGGTTACCGTTTTAGCCCGGAGCCGTGTGTTGT
CCAGCGAAGATCCTACGATCGGAGAGGCCATAGAGGCGGCTTTTAAACGGGAAGGGATTGAGGTGCTTCGCCAGACCACG
CCCAGCAACGTGGACTATAGCGACAACGAGTTTATCGTCGAGACGCCTGCCGGCACCTTGCGAGCCGACCAACTACTGGT
GGCGACCGGTCGAACGCCCAATACCGAGGCCCTGAACCTGGCGAGCATTGGCGTGGAAACTTCACGCGGCGCAATTCAGG
TGGATGAGCATCTGCAAACCACGGTCACCGGAATATACGCTGCTGGTGACTGCACCAATCAACCGCAGTTTGTCTATGTC
GCAGCTGCCGCAGGCAGCCGAGCCGCCGTCAACATGACGGGAGGCGAGGCCAAACTCGACCTCAGTGCCATGCCCGGGGT
CATGTTCACCGATCCTCAAGTCGCCACCGTTGGCCTCACTGAAGCCGAAGCAGTTGCTCGGGGTTATAGCGTGGACACCA
GGCTGCTCGACTTGGAAAACGTGCCGCGTGCGCTAGTAAACTTTGACACCCATGGATTTATTAAAATGGTAGCAGAGCGC
AGCACAGGCCGTTTGCTCGGGGTGCAGGTTGTCGCAGCGGAAGGCGGTGAAATTATCCAAACGGCAGTGATGGCGTTACG
AGCAGGTTTGACCGTTCAGGAAATCGGCGATGACTTGTTCCCTTATCTGACCATGGTTGAAGGACTCAAACTCTGTGCGC
AAACGTTCACCAAGGATGTAAAGCAGTTGTCCTGCTGTGCCGGTTAA

Protein sequence : 
MKNDNKLHIAVIGSGGAAMAAALKATERGARVTLIERGTVGGTCVNVGCVPSKIMIRAAHIAHLRKESPFDAGISAEAPQ
VDRAKLLQQQQARVEELRDTKYEKILREHKDITVLNGEARFVDTNSLVVTLAEGGEKPVHFDRAFIGTGARPAEPPITGL
ADTPYLTSTSALALDTVPKRLIVIGAGFVSLELAQAFDRLGSKVTVLARSRVLSSEDPTIGEAIEAAFKREGIEVLRQTT
PSNVDYSDNEFIVETPAGTLRADQLLVATGRTPNTEALNLASIGVETSRGAIQVDEHLQTTVTGIYAAGDCTNQPQFVYV
AAAAGSRAAVNMTGGEAKLDLSAMPGVMFTDPQVATVGLTEAEAVARGYSVDTRLLDLENVPRALVNFDTHGFIKMVAER
STGRLLGVQVVAAEGGEIIQTAVMALRAGLTVQEIGDDLFPYLTMVEGLKLCAQTFTKDVKQLSCCAG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 6e-130 68
merA ABQ57371.1 MerA Not tested SGI1 Protein 2e-132 68
merA AGK07021.1 MerA Not tested SGI1 Protein 2e-132 68
merA AGK07079.1 MerA Not tested SGI1 Protein 2e-132 68
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 3e-133 68
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 2e-133 68
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 3e-132 67
merA AFG30120.1 MerA Not tested PAGI-2 Protein 6e-132 67
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 8e-132 67
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 6e-132 67
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 2e-77 46
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 1e-77 46

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
merA YP_005429838.1 Mercuric reductase (Hg(II) reductase) BAC0653 Protein 1e-133 68
merA YP_005429838.1 Mercuric reductase (Hg(II) reductase) BAC0652 Protein 2e-132 68
merA YP_005429838.1 Mercuric reductase (Hg(II) reductase) BAC0650 Protein 5e-127 65
merA YP_005429838.1 Mercuric reductase (Hg(II) reductase) BAC0224 Protein 4e-78 47
merA YP_005429838.1 Mercuric reductase (Hg(II) reductase) BAC0651 Protein 8e-78 46