Gene Information

Name : hsdM (MGAS1882_1534)
Accession : YP_005412249.1
Strain : Streptococcus pyogenes MGAS1882
Genome accession: NC_017053
Putative virulence/resistance : Unknown
Product : type I restriction-modification system DNA-methyltransferase subunit HsdM
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 1511836 - 1513416 bp
Length : 1581 bp
Strand : +
Note : CDD hit: non-specific, cl13579 = HsdM N-terminal domain; This domain is found at the N-terminus of the methylase subunit of Type I DNA methyltransferases. This domain family is found in bacteria and archaea, and is typically between 123 and 138 amino acid

DNA sequence :
ATGGCAGAGAAAACAACTTCACTCCGTCAAGCACTATGGCATTCGGCCGACCAATTACGTGGCCAAATGGATGCCAATGA
CTATAAAAACTATCTTCTTGGACTTATTTTTTACAAACACTTATCTGATAAATTACTCTTGGCTGTTTGTGATAATCTAG
AAAAACACTTCAATACCTTTACAGAGGCTCAAAAAATCTTTGAAGATGCTTATCAAGATGAAGGCCTAAAAGATGACCTC
ATTTCTGTTGTTACTGGTGATTTAGGTTACTTTATCGAACCAACACTGACCTTTGAAAAACTCATCCAAGATGTTTATCA
CAATACTTTCCAATTAGAATCATTAGCTCAAGGTTTTCGCGATATTGAACAAAGTGGTGAAGACTTTGAAAACTTATTTG
AAGATATTGACCTCTACTCTAAAAAATTAGGCTCTACTCCTCAAAAACAAAATCAAACCATTTCTAATGTCATGAAAACA
TTAAATGAAATTGACTTTGAGGCAGTAGATGGGGATACTTTAGGCGATGCTTATGAGTACTTGATTGGTGAATTTGCCAG
TGAGTCAGGAAAAAAAGCAGGTGAGTTCTATACCCCACAAGCTGTCTCTCACTTGATGACTCAGATTGTCTTTTTAGGTC
GTGAAGATCAAAAAGGAATGACCCTCTATGACCCTGCTATGGGATCTGGATCACTCCTTTTAAATGCTAAGAAATATAGT
AACCAATCCGATACCGTTTCTTACTATGGTCAAGAAATCAATACTTCTACTTATAACTTGGCTCGTATGAACATGATGCT
TCATGGCGTTGCCATCGAAAACCAACACTTAAGTAACGCTGATACCTTGGATGCAGACTGGCCAACAGATGAGCCAACCA
ACTTTGATGGGGTGTTGATGAACCCACCTTATTCTTTGAAATGGTCAGCGACTGCTGGTTTCTTAACGGATCCACGTTTT
TCAAGTTATGGTGTATTAGCACCAAAATCAAAAGCTGACTTTGCCTTTTTACTTCATGGTTTCTATCATTTAAAAAATAC
AGGAACTATGGCGATTGTCTTACCACACGGTGTTCTTTTCCGTGGAGCTGCAGAAGGCAAGATTCGCCAAAAGCTACTCG
AACAAGGGGCTATCGATACCATTATCGGACTCCCATCAAATATCTTTTATAATACAAGCATCCCTACGACTATTATCATA
TTAAAGAAGAACAGAACCAACAAAGATGTCTTCTTTATCGATGCTTCAAAAGAGTTTGATAAGGGCAAAAATCAAAACAC
AATGACAGATAGCCATATCAAAAAGATCCTTGATGCTTATAAGAGTCGTGATAATTCTGATAAGTTTTCATACTTAGCCT
CATTTGATGAAATCATTGAAAATGACTATAACTTAAATATCCCACGCTATGTTGATACCTTTGAGGAAGTCCCCGTCAAA
CCACTGCCAGAATTAGCTAAACAGCTCAGTGACATTGATCAAGAAATTGCCAAAACAAATGCCAAACTAGATCAACTCAT
GAAACAACTAGTCGGAACAACCAAAGAAGCACAAGACGAATTGGATACTTTTAGAAACTAA

Protein sequence :
MAEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKLLLAVCDNLEKHFNTFTEAQKIFEDAYQDEGLKDDL
ISVVTGDLGYFIEPTLTFEKLIQDVYHNTFQLESLAQGFRDIEQSGEDFENLFEDIDLYSKKLGSTPQKQNQTISNVMKT
LNEIDFEAVDGDTLGDAYEYLIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGREDQKGMTLYDPAMGSGSLLLNAKKYS
NQSDTVSYYGQEINTSTYNLARMNMMLHGVAIENQHLSNADTLDADWPTDEPTNFDGVLMNPPYSLKWSATAGFLTDPRF
SSYGVLAPKSKADFAFLLHGFYHLKNTGTMAIVLPHGVLFRGAAEGKIRQKLLEQGAIDTIIGLPSNIFYNTSIPTTIII
LKKNRTNKDVFFIDASKEFDKGKNQNTMTDSHIKKILDAYKSRDNSDKFSYLASFDEIIENDYNLNIPRYVDTFEEVPVK
PLPELAKQLSDIDQEIAKTNAKLDQLMKQLVGTTKEAQDELDTFRN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SSP0053 YP_300143.1 type I restriction-modification system methyltransferase subunit Not tested SCC15305cap Protein 2e-113 49
SAMSHR1132_03780 YP_005324900.1 putative type I restriction enzyme modification protein Not tested vSa¥á Protein 2e-110 47
SAS0394 YP_042520.1 restriction enzyme modification protein Not tested vSa¥á Protein 4e-110 47
hsdM2 YP_186690.1 type I restriction-modification system, M subunit Not tested vSa¥â Protein 1e-110 47
SAR0433 YP_039884.1 type I restriction enzyme modification protein Not tested vSa¥á Protein 3e-110 47
ORF6 BAC22943.1 - Not tested etd PI Protein 3e-110 47
SAKOR_00415 YP_008490599.1 Type I restriction-modification system methylation subunit Not tested vSa¥á Protein 1e-110 47
hsdM NP_645209.1 type I site-specific deoxyribonuclease LldI chain hsdM Not tested vSa¥á Protein 3e-110 47
hsdM1 YP_185366.1 type I restriction-modification system, M subunit Not tested vSa¥á Protein 1e-110 47
hsdM NP_373642.1 type I site-specific deoxyribonuclease LldI subunit HsdM Not tested vSa¥á Protein 3e-110 47
hsdM YP_001331432.1 type I restriction-modification system, methyltransferase subunit Not tested vSa¥á Protein 1e-110 47
SAS1732 YP_043848.1 type I restriction enzyme modification protein Not tested vSa¥â Protein 3e-110 47
hsdM YP_493119.1 type I restriction-modification system, M subunit Not tested vSa¥á Protein 1e-110 47
hsdM NP_646568.1 hypothetical protein Not tested vSa¥â Protein 3e-110 47
SAR1899 YP_041281.1 type I restriction modification system modification protein Not tested vSa¥â Protein 2e-109 47
SAV1808 NP_372332.1 type I restriction enzyme EcoR124II M protein Not tested vSa¥â Protein 3e-110 47
hsdM NP_370955.1 type I site-specific deoxyribonuclease LldI chain Not tested vSa¥á Protein 9e-110 47
SA1626 NP_374915.1 hypothetical protein Not tested vSa¥â Protein 3e-110 47
SAMSHR1132_16570 YP_005326167.1 restriction-modification system, M subunit Not tested vSa¥â Protein 4e-110 47
hsdM YP_494443.1 type I restriction-modification system, M subunit Not tested vSa¥â Protein 7e-111 47
SAKOR_01757 YP_008491945.1 Type I restriction-modification system methylation subunit Not tested vSa¥â Protein 1e-110 47
hsdM YP_001332734.1 type I restriction-modification system, methyltransferase subunit Not tested vSa¥â Protein 7e-111 47