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Name : pyk (MGAS15252_0990) Accession : YP_005389030.1 Strain : Streptococcus pyogenes MGAS15252 Genome accession: NC_017040 Putative virulence/resistance : Virulence Product : Pyruvate kinase, Pyk Function : - COG functional category : - COG ID : - EC number : - Position : 975824 - 977326 bp Length : 1503 bp Strand : - Note : CDD hit: non-specific, cl9155 = Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate aff DNA sequence : ATGAATAAACGCGTAAAAATCGTTGCAACACTTGGTCCTGCGGTTGAAATCCGTGGTGGTAAAAAATACGGAGAAGATGG CTACTGGGCTGGTCAACTTGATGTTGAAGAATCTGCAAAAAAAATCGCTGAATTAATTGAAGCTGGTGCGAATGTTTTCC GTTTCAATTTCTCACATGGTGACCACAAAGAACAAGGTGACCGTATGGCAACTGTTCGCCTTGCAGAAGAAATTGCTCGT CAAAAAGTTGGTTTCCTTTTGGATACTAAAGGTCCTGAAATGCGTACGGAATTGTTTGCAGATGATGCTAAAGAGTTTAG CTATGTTACTGGAGAAAAAATCCGTGTAGCGACTACACAAGGTATTCAATCAACTCGCGATGTTATTGCTTTGAACGTTG CTGGTAGCCTTGACATCTACGATGAAGTAGAAGTAGGTCATACTATTCTTATCGATGATGGTAAACTTGGTTTGAAAGTG ATCGACAAAGATATCGCAACACGTCAATTTATCGTTGAAGTAGAAAACGACGGTATTATTGCTAAACAAAAAGGTGTTAA TATCCCTAACACTAAAATTCCTTTCCCAGCACTTGCGGAACGCGACAATGCTGATATCCGTTTTGGTCTTGAACAAGGAC TTAACTTTATTGCAATCTCATTTGTTCGTACAGCCAAAGACGTTGAGGAAGTTCGTGAAATCTGTCGCGAAACTGGTAAC GACCATGTGCAATTATTTGCTAAGATTGAAAACCAACAAGGTATCGATAATCTTGATGAAATCATCGAAGCTGCTGATGG TATCATGATTGCACGTGGCGACATGGGTATCGAAGTACCATTTGAAATGGTTCCAGTTTTCCAAAAAATGATTATCACTA AAGTGAATGCAGCTGGTAAAGCAGTTATCACAGCAACAAACATGCTTGAAACAATGACTGAAAAACCACGTGCGACACGT TCTGAAGTATCTGACGTCTTCAATGCTGTTATCGATGGTACTGATGCAACAATGCTTTCAGGAGAGTCCGCTAACGGTAA ATACCCGGTTGAATCTGTTCGTACAATGGCGACTATTGATCGTAATGCACAAACTCTTCTTAACGAATATGGTCGTTTAG ATTCATCTGCCTTCCCACGTACCAATAAAACAGATGTTATTGCTTCAGCTGTTAAAGATGCCACTCATTCAATGGACATC AAACTTGTTGTGACTATTACTGAGACAGGTAATACAGCTCGTGCGATTTCTAAATTCCGTCCAGATGCGGACATCTTAGC TGTAACATTTGATGAAAAAGTACAACGTGCTTTGATGATTAACTGGGGTGTTATTCCTGTTCTTGCTGAAAAACCTGCAT CTACTGATGACATGTTTGAAGTAGCAGAGCGTGTTGCTGTGGAGGCAGGCTTAGTTCAATCTGGGGATAATATTGTTATT GTTGCTGGTGTTCCAGTAGGATCAGGCGGAACAAACACAATGCGCGTTCGTACCGTAAAATAA Protein sequence : MNKRVKIVATLGPAVEIRGGKKYGEDGYWAGQLDVEESAKKIAELIEAGANVFRFNFSHGDHKEQGDRMATVRLAEEIAR QKVGFLLDTKGPEMRTELFADDAKEFSYVTGEKIRVATTQGIQSTRDVIALNVAGSLDIYDEVEVGHTILIDDGKLGLKV IDKDIATRQFIVEVENDGIIAKQKGVNIPNTKIPFPALAERDNADIRFGLEQGLNFIAISFVRTAKDVEEVREICRETGN DHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVFQKMIITKVNAAGKAVITATNMLETMTEKPRATR SEVSDVFNAVIDGTDATMLSGESANGKYPVESVRTMATIDRNAQTLLNEYGRLDSSAFPRTNKTDVIASAVKDATHSMDI KLVVTITETGNTARAISKFRPDADILAVTFDEKVQRALMINWGVIPVLAEKPASTDDMFEVAERVAVEAGLVQSGDNIVI VAGVPVGSGGTNTMRVRTVK |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| STY1744 | NP_456147.1 | pyruvate kinase | Not tested | SPI-2 | Protein | 1e-80 | 43 |
| pykF | YP_216386.1 | pyruvate kinase | Not tested | SPI-2 | Protein | 5e-81 | 43 |
| pykF | NP_805051.1 | pyruvate kinase | Not tested | SPI-2 | Protein | 5e-81 | 43 |
| pykF | CAA68205.1 | pyruvate kinase like protein | Not tested | SPI-2 | Protein | 3e-81 | 43 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| pyk | YP_005389030.1 | Pyruvate kinase, Pyk | VFG0479 | Protein | 2e-81 | 43 |
