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Name : guaA (MGAS15252_0916) Accession : YP_005388958.1 Strain : Streptococcus pyogenes MGAS15252 Genome accession: NC_017040 Putative virulence/resistance : Unknown Product : GMP synthase, GuaA Function : - COG functional category : - COG ID : - EC number : - Position : 898717 - 900279 bp Length : 1563 bp Strand : + Note : CDD hit: specific, cl292 = The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel DNA sequence : ATGACTGAAATTTCAATTTTGAATGATGTTCAAAAAATTATCGTTCTTGATTATGGTAGCCAGTACAATCAGCTTATTGC TAGACGTATTCGAGAGTTTGGTGTTTTCTCCGAACTAAAAAGCCATAAAATCACCGCTCAAGAACTTCGTGAGATCAATC CCATAGGTATCGTTTTATCAGGAGGGCCTAACTCTGTTTACGCTGATAACGCCTTTGGCATTGACCCTGAAATCTTTGAA CTAGGGATTCCGATTCTTGGTATCTGTTACGGTATGCAATTAATCACCCATAAATTAGGTGGTAAAGTTGTTCCTGCTGG ACAAGCTGGTAATCGTGAGTACGGTCAGTCAACCCTTCATCTTCGTGAAACGTCAAAATTATTTTCAGGCACACCTCAAG AACAACTCGTTTTGATGAGCCATGGTGATGCTGTTACTGAAATTCCAGAAGGTTTCCACCTTGTTGGAGACTCAAATGAC TGTCCCTATGCAGCTATTGAAAATACTGAGAAAAACCTCTACGGTATTCAGTTCCACCCAGAAGTGAGACACTCTGTTTA TGGAAATGACATTCTTAAAAACTTTGCTATATCAATTTGTGGCGCGCGTGGTGATTGGTCAATGGATAATTTTATTGACA TGGAAATTGCTAAAATTCGTGAAACTGTAGGCGATCGTAAAGTTCTTCTAGGTCTTTCTGGTGGAGTTGATTCTTCAGTT GTTGGTGTTCTACTTCAAAAAGCTATCGGTGACCAATTAACTTGTATTTTCGTTGATCACGGTCTTCTTCGTAAAGACGA GGGCGATCAAGTTATGGGAATGCTTGGGGGCAAATTTGGCCTAAATATTATCCGTGTGGATGCTTCAAAACGTTTCTTAG ACCTTCTTGCAGACGTTGAAGATCCTGAGAAAAAACGTAAAATTATTGGTAATGAATTTGTCTATGTTTTTGATGATGAA GCCAGCAAATTAAAAGGTGTTGACTTCCTTGCCCAAGGAACACTTTATACTGATATCATTGAGTCAGGAACAGAAACTGC TCAAACCATCAAATCACATCACAATGTGGGTGGTCTCCCCGAAGACATGCAGTTTGAATTGATTGAGCCCTTAAACACTC TTTTCAAAGATGAAGTTCGAGCGCTTGGAATCGCTCTTGGAATGCCTGAAGAAATTGTTTGGCGCCAACCATTTCCAGGT CCTGGACTTGCTATCCGTGTCATGGGAGCAATTACTGAAGAAAAACTTGAAACCGTTCGCGAATCAGACGCTATCCTTCG TGAAGAAATTGCTAAGGCTGGACTTGATCGTGACGTGTGGCAATACTTTACAGTTAACACAGGTGTCCGTTCTGTAGGCG TCATGGGAGATGGTCGTACTTATGATTATACCATCGCCATTCGTGCTATTACGTCTATTGATGGTATGACAGCTGACTTT GCTCAACTTCCTTGGGATGTCTTGAAAAAAATCTCAACACGTATCGTAAATGAAGTTGACCACGTTAACCGTATCGTCTA CGACATCACAAGTAAACCACCCGCAACAGTTGAATGGGAATAA Protein sequence : MTEISILNDVQKIIVLDYGSQYNQLIARRIREFGVFSELKSHKITAQELREINPIGIVLSGGPNSVYADNAFGIDPEIFE LGIPILGICYGMQLITHKLGGKVVPAGQAGNREYGQSTLHLRETSKLFSGTPQEQLVLMSHGDAVTEIPEGFHLVGDSND CPYAAIENTEKNLYGIQFHPEVRHSVYGNDILKNFAISICGARGDWSMDNFIDMEIAKIRETVGDRKVLLGLSGGVDSSV VGVLLQKAIGDQLTCIFVDHGLLRKDEGDQVMGMLGGKFGLNIIRVDASKRFLDLLADVEDPEKKRKIIGNEFVYVFDDE ASKLKGVDFLAQGTLYTDIIESGTETAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGIALGMPEEIVWRQPFPG PGLAIRVMGAITEEKLETVRESDAILREEIAKAGLDRDVWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADF AQLPWDVLKKISTRIVNEVDHVNRIVYDITSKPPATVEWE |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| SAPIG0468 | YP_005733278.1 | GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) | Not tested | SAPI-S0385 | Protein | 1e-174 | 69 |
| SAMSHR1132_03620 | YP_005324884.1 | GMP synthase | Not tested | vSa¥á | Protein | 1e-174 | 69 |
| guaA | YP_001331415.1 | GMP synthase | Not tested | vSa¥á | Protein | 4e-175 | 69 |
| guaA | NP_938969.1 | GMP synthase | Not tested | Not named | Protein | 2e-119 | 52 |
