Gene Information

Name : apbA (MGAS15252_0686)
Accession : YP_005388733.1
Strain : Streptococcus pyogenes MGAS15252
Genome accession: NC_017040
Putative virulence/resistance : Unknown
Product : 2-dehydropantoate 2-reductase protein ApbA
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 668455 - 669378 bp
Length : 924 bp
Strand : +
Note : CDD hit: multi-dom, TIGR745 = 2-dehydropantoate 2-reductase; This model describes enzymes that perform as 2-dehydropantoate 2-reductase, one of four enzymes required for the de novo biosynthesis of pantothenate (vitamin B5) from Asp and 2-oxoisovalerate.

DNA sequence :
ATGTTAGTTTATATTGCTGGCTCAGGAGCCATGGGGTGCCGTTTTGGTTACCAAATTTCAAAAACAAATAACGATGTGAT
TTTGTTAGATAACTGGGAAGATCATATCAATGCCATTAAAGAAAACGGTTTAGTGGTGACAGGGGATGTGGAAGAAACAG
TTAAGCTTCCTATTATGAAACCGACTGAAGCCACTCAAGAAGCCGATTTGATTATCTTGTTTACAAAAGCAATGCAGTTG
CCACAAATGCTTCAAGACATTAAAGGCATTATTGGAAAAGAAACCAAAGTGCTTTGCCTTTTAAATGGTCTTGGACACGA
AGACGTTATTCGTCAGTACATTCCAGAGCACAACATTTTGATGGGGGTCACTGTCTGGACTGCTGGTCTAGAAGGTCCTG
GTCGTGCTCATCTTCAAGGTGTGGGAGCACTTAACTTACAAAGCATGGATCCAAGCAATCAAGAAGCTGGACACCAAGTG
GCTGATTTGTTAAATGAAGCTAACTTGAATGCGACTTATGATGAGAATGTTGTGCCAAACATCTGGCGGAAAGCTTGCGT
GAATGGTACCATGAACTCAACTTGTGCCCTTCTAGATTGTACAATTGGTGAATTATTTGCCAGTGAAGACGGTCTCAAAA
TGGTAAAAGAAATCATCCATGAGTTTGTTATCGTTGGTCAAGCAGAAGGTGTCGAACTAAACGAAGAAGAAATCACACAA
TATGTAATGGATACATCTGTTAAAGCTGCTCACCATTACCCATCAATGCACCAAGACCTTGTGCAAAATCACCGATTGAC
TGAAATTGATTTTATCAATGGTGCAGTCAATACCAAAGGTGAAAAGCTTGGTATCAATACTCCATACTGCCGTATGATTA
CAGAGCTAGTTCACGCTAAAGAAGCAGTGTTGAACATCCAATAA

Protein sequence :
MLVYIAGSGAMGCRFGYQISKTNNDVILLDNWEDHINAIKENGLVVTGDVEETVKLPIMKPTEATQEADLIILFTKAMQL
PQMLQDIKGIIGKETKVLCLLNGLGHEDVIRQYIPEHNILMGVTVWTAGLEGPGRAHLQGVGALNLQSMDPSNQEAGHQV
ADLLNEANLNATYDENVVPNIWRKACVNGTMNSTCALLDCTIGELFASEDGLKMVKEIIHEFVIVGQAEGVELNEEEITQ
YVMDTSVKAAHHYPSMHQDLVQNHRLTEIDFINGAVNTKGEKLGINTPYCRMITELVHAKEAVLNIQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
EF0517 NP_814296.1 2-dehydropantoate 2-reductase Not tested Not named Protein 2e-72 50
ef0037 AAM75243.1 EF0037 Not tested Not named Protein 1e-72 50