Gene Information

Name : lysS (MGAS15252_0521)
Accession : YP_005388570.1
Strain : Streptococcus pyogenes MGAS15252
Genome accession: NC_017040
Putative virulence/resistance : Virulence
Product : lysyl-tRNA synthetase protein LysS
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 482426 - 483919 bp
Length : 1494 bp
Strand : -
Note : CDD hit: specific, cl268 = Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presen

DNA sequence :
ATGTCTAATCAACACATCGAAGAATTAAATGACCAACAGATTGTCCGTCGTGAAAAAATGACGGCGCTGGCTGAACAAGG
AATTGATCCTTTCGGTAAACGCTTTGACCGCACAGCCAATTCTGCTGAATTAAAAGAAAAGTATGCTGATAAAACAAAAG
AAGAATTACATGAGTTAAACGAAACAGCTATTGTTGCTGGCCGCTTGATGACAAAACGTGGCAAAGGTAAGGTTGGTTTT
GCTCATCTTCAAGACCGTGAAGGCCAAATCCAACTTTATGTTCGCAAGGACTCTGTTGGCGAAGACAACTATGAAATCTT
CAAAAAAGCCGATTTAGGCGACTTTATCGGCGTTGAAGGCGAAGTCATGCGTACAGACATGGGCGAGTTGTCAATCAAGG
CAACCAAGTTGACTCACCTTTCTAAATCACTTCGTCCTCTTCCTGAAAAATTCCACGGATTAACTGATATTGAAACCATT
TACCGTAAGCGTCACCTTGATTTAATTTCAAATCGTGAAAGCTTTGACCGCTTCGTGACCCGTTCCAAAATGATTTCAGA
AATCCGTCGTTATTTAGACGGTCTTGATTTCCTAGAAGTAGAAACGCCTGTGCTTCATAACGAGGCTGGTGGTGCTGCTG
CTCGTCCTTTCGTTACTCACCATAATGCTCAAAACATTGATATGGTGCTTCGTATCGCAACAGAACTTCATTTGAAACGT
TTGATTGTTGGTGGTATGGAACGTGTCTATGAAATTGGTCGTATCTTCCGTAACGAGGGAATGGATGCTACTCATAATCC
TGAGTTCACTTCTATTGAGGTTTACCAAGCCTATGCAGACTATCTTGATATCATGAACCTGACAGAAGGCATTATCCAAC
ATGCTGCTAAAGCTGTTAAAGGTGATGGCCCTATTGATTATCAAGGAACTGAAATCCGTATCAATGAACCTTTCAAACGT
GTCCACATGGTAGATGCTATCAAGGAAGTGACAGGTGTTGATTTCTGGCCTGAAATGACTGTCGAAGAAGCTATTGCACT
TGCCAAAGAAAAACAGGTCCCACTCGAAAAACACTTCACAAGTGTCGGACATATCATCAATGCTTTCTTCGAAGAATTCG
TTGAAGAAACCTTGGTCCAACCAACCTTTGTGTTTGGTCATCCTGTTGAAGTATCGCCTTTGGCTAAGAAGAATCCAGAA
GATACCCGCTTCACCGACCGCTTCGAACTTTTCATCATGACCAAAGAATACGCCAATGCTTTCACAGAGTTGAATGATCC
CATTGACCAATTATCTCGTTTTGAAGCACAAGCACAAGCCAAAGAACTTGGTGATGACGAAGCAACTGGCATTGACTACG
ACTTCGTTGAAGCTCTTGAATATGGTATGCCGCCAACCGGTGGACTCGGAATTGGGATTGATCGTCTTTGCATGTTATTA
ACAAACACAACAACAATCAGAGATGTGCTTTTATTCCCAACGATGAAACCTTAA

Protein sequence :
MSNQHIEELNDQQIVRREKMTALAEQGIDPFGKRFDRTANSAELKEKYADKTKEELHELNETAIVAGRLMTKRGKGKVGF
AHLQDREGQIQLYVRKDSVGEDNYEIFKKADLGDFIGVEGEVMRTDMGELSIKATKLTHLSKSLRPLPEKFHGLTDIETI
YRKRHLDLISNRESFDRFVTRSKMISEIRRYLDGLDFLEVETPVLHNEAGGAAARPFVTHHNAQNIDMVLRIATELHLKR
LIVGGMERVYEIGRIFRNEGMDATHNPEFTSIEVYQAYADYLDIMNLTEGIIQHAAKAVKGDGPIDYQGTEIRINEPFKR
VHMVDAIKEVTGVDFWPEMTVEEAIALAKEKQVPLEKHFTSVGHIINAFFEEFVEETLVQPTFVFGHPVEVSPLAKKNPE
DTRFTDRFELFIMTKEYANAFTELNDPIDQLSRFEAQAQAKELGDDEATGIDYDFVEALEYGMPPTGGLGIGIDRLCMLL
TNTTTIRDVLLFPTMKP

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed CAD66193.1 putative lysil-tRNA synthetase LysU Not tested PAI III 536 Protein 1e-105 47

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
lysS YP_005388570.1 lysyl-tRNA synthetase protein LysS VFG1668 Protein 6e-106 47