Gene Information

Name : fhuC (MGAS15252_0350)
Accession : YP_005388402.1
Strain : Streptococcus pyogenes MGAS15252
Genome accession: NC_017040
Putative virulence/resistance : Virulence
Product : ferrichrome transport ATP-binding protein FhuC
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 325501 - 326283 bp
Length : 783 bp
Strand : -
Note : CDD hit: specific, cl999 = ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD

DNA sequence :
ATGACAACAATTAGTGCTGAAGACCTCACAATTGCCTATGAACAGCGTACCATCATCGATAAATTATCGTTTTATATTCC
TGAAGGTAAAATTACGACCATTATTGGCGCCAATGGCTGTGGGAAGTCTAGTTTATTAAAAGCACTGACAAGATTATTAC
CACCAAAACAGGGAGTTGTATATTTAAATGGGCAAAACATTGCCACATTAGAAACTAAAGAGGTTGCTAAAAAACTAGCT
CTTTTACCTCAAGTTCAAGAAGCAACTAACGGTATAACTGTTTACGAATTGGTTTCTTACGGACGTTTTCCCCATCAATC
TTACTTTGGAAATCTTAGTCCAGCTGACAAAAAAGCCATTCATTGGGCTATGCAAGCCACCAATGTCATGGCCTATGCTG
ATCAACCTGTTGATGCTCTTTCTGGGGGGCAACGTCAAAGGGTTTGGCTTGCAATGGCATTAGCCCAAGGCACTGATACT
ATTTTTTTAGATGAGCCAACTACTTATTTAGATTTAAATCATCAACTAGAAATCCTAGAGCTCGTTAAATCCCTAAATAA
GGATGCCGGCAAGACTATTGTTATGGTTCTTCACGACCTCAATCTTTCAGCCCGCTATTCGGATCATCTGATTGCTATGA
AACATGGCAAGATCCATTATACTGGTACTATAGCAGATGTTATGACTTCACCTATCATTCAAGACATCTTCCAAATCAAA
CCGGTACTGGTTGATGATCCTATCCACAACTGTCCTATAGTGCTGACTTATCAGCTTCAATAA

Protein sequence :
MTTISAEDLTIAYEQRTIIDKLSFYIPEGKITTIIGANGCGKSSLLKALTRLLPPKQGVVYLNGQNIATLETKEVAKKLA
LLPQVQEATNGITVYELVSYGRFPHQSYFGNLSPADKKAIHWAMQATNVMAYADQPVDALSGGQRQRVWLAMALAQGTDT
IFLDEPTTYLDLNHQLEILELVKSLNKDAGKTIVMVLHDLNLSARYSDHLIAMKHGKIHYTGTIADVMTSPIIQDIFQIK
PVLVDDPIHNCPIVLTYQLQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
fagC YP_003782430.1 ABC transporter ATP-binding protein Not tested PiCp 1 Protein 2e-58 47
fagC YP_005682397.1 ATP binding cytoplasmic membrane protein Virulence PiCp 1 Protein 2e-58 47
fagC YP_005684488.1 ATP binding cytoplasmic membrane protein Not tested PiCp 1 Protein 2e-58 47
fagC YP_005680307.1 ATP binding cytoplasmic membrane protein Not tested PiCp 1 Protein 2e-58 47
iusE YP_005143742.1 iron ABC transporter ATP-binding protein Virulence Not named Protein 6e-59 46
SPN23F_09560 YP_002510939.1 ferric siderophore ABC transporter ATP-binding protein Virulence PPI-1 Protein 2e-53 45
SP_1035 NP_345510.1 iron-compound ABC transporter ATP-binding protein Not tested PPI-1 Protein 2e-53 45
DIP0585 NP_938961.1 iron ABC transporter ATP-binding protein Virulence Not named Protein 1e-50 45
fecE AAL08451.1 ATP-binding protein FecE Virulence SRL Protein 2e-52 44
ciuD YP_005683346.1 Iron ABC transporter ATP-binding protein Virulence PiCp 4 Protein 6e-51 43
ciuD YP_003783391.1 iron ABC transporter ATP-binding protein Virulence PiCp 4 Protein 6e-51 43
ciuD YP_005685432.1 Iron ABC transporter ATP-binding protein Virulence PiCp 4 Protein 6e-51 43
ciuD YP_005681255.1 Iron ABC transporter ATP-binding protein Virulence PiCp 4 Protein 6e-51 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
fhuC YP_005388402.1 ferrichrome transport ATP-binding protein FhuC BAC0164 Protein 1e-52 44

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
fhuC YP_005388402.1 ferrichrome transport ATP-binding protein FhuC VFG0925 Protein 3e-58 46
fhuC YP_005388402.1 ferrichrome transport ATP-binding protein FhuC VFG1042 Protein 9e-53 44