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Name : covR (MGAS15252_0310) Accession : YP_005388362.1 Strain : Streptococcus pyogenes MGAS15252 Genome accession: NC_017040 Putative virulence/resistance : Virulence Product : TCS signal transduction response regulator CovR/CsrR Function : - COG functional category : - COG ID : - EC number : - Position : 289064 - 289750 bp Length : 687 bp Strand : + Note : CDD hit: specific, cl9944 = Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two DNA sequence : ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA Protein sequence : MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| copR | NP_460069.2 | transcriptional regulatory protein YedW | Not tested | SPI-5 | Protein | 8e-37 | 43 |
| copR | AAC33719.1 | regulatory protein CopR | Not tested | SPI-5 | Protein | 3e-36 | 43 |
| c3565 | NP_755440.1 | response regulator | Not tested | PAI I CFT073 | Protein | 4e-33 | 41 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| covR | YP_005388362.1 | TCS signal transduction response regulator CovR/CsrR | HE999704.1.gene1528. | Protein | 6e-59 | 62 |
| covR | YP_005388362.1 | TCS signal transduction response regulator CovR/CsrR | AE015929.1.gene1106. | Protein | 3e-49 | 54 |
| covR | YP_005388362.1 | TCS signal transduction response regulator CovR/CsrR | NC_002952.2859858.p0 | Protein | 3e-51 | 53 |
| covR | YP_005388362.1 | TCS signal transduction response regulator CovR/CsrR | NC_007622.3794948.p0 | Protein | 3e-51 | 53 |
| covR | YP_005388362.1 | TCS signal transduction response regulator CovR/CsrR | NC_003923.1003417.p0 | Protein | 3e-51 | 53 |
| covR | YP_005388362.1 | TCS signal transduction response regulator CovR/CsrR | NC_013450.8614146.p0 | Protein | 3e-51 | 53 |
| covR | YP_005388362.1 | TCS signal transduction response regulator CovR/CsrR | NC_002951.3238224.p0 | Protein | 3e-51 | 53 |
| covR | YP_005388362.1 | TCS signal transduction response regulator CovR/CsrR | NC_007793.3914065.p0 | Protein | 3e-51 | 53 |
| covR | YP_005388362.1 | TCS signal transduction response regulator CovR/CsrR | NC_002758.1121390.p0 | Protein | 3e-51 | 53 |
| covR | YP_005388362.1 | TCS signal transduction response regulator CovR/CsrR | NC_010079.5776364.p0 | Protein | 3e-51 | 53 |
| covR | YP_005388362.1 | TCS signal transduction response regulator CovR/CsrR | NC_012469.1.7685629. | Protein | 2e-38 | 43 |
| covR | YP_005388362.1 | TCS signal transduction response regulator CovR/CsrR | HE999704.1.gene2815. | Protein | 3e-39 | 42 |
| covR | YP_005388362.1 | TCS signal transduction response regulator CovR/CsrR | BAC0125 | Protein | 7e-36 | 41 |
| covR | YP_005388362.1 | TCS signal transduction response regulator CovR/CsrR | AE016830.1.gene1681. | Protein | 3e-39 | 41 |
| covR | YP_005388362.1 | TCS signal transduction response regulator CovR/CsrR | BAC0197 | Protein | 2e-32 | 41 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| covR | YP_005388362.1 | TCS signal transduction response regulator CovR/CsrR | VFG1390 | Protein | 3e-41 | 43 |
| covR | YP_005388362.1 | TCS signal transduction response regulator CovR/CsrR | VFG0596 | Protein | 3e-37 | 43 |
| covR | YP_005388362.1 | TCS signal transduction response regulator CovR/CsrR | VFG1702 | Protein | 2e-33 | 41 |
