Gene Information

Name : nanE (MGAS15252_0239)
Accession : YP_005388298.1
Strain : Streptococcus pyogenes MGAS15252
Genome accession: NC_017040
Putative virulence/resistance : Unknown
Product : N-acetylmannosamine-6-phosphate epimerase protein NanE
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 215439 - 216143 bp
Length : 705 bp
Strand : +
Note : CDD hit: specific, cl918 = N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Si

DNA sequence :
ATGCCTGATAAACCAACCAAAGAAAAGCTCATGGAGCAGTTAAAGGGTGGGATTATCGTTTCTTGTCAGGCTTTGCCAGG
TGAGCCTCTTTATTCAGAGACTGGGGGTATTATGCCACTGCTGGCAAAAGCTGCTCAAGAAGCTGGTGCTGTCGGCATCA
GAGCTAATTCGGTTAGGGATATTAAAGAAATTCAAGCCATAACAGACCTACCAATTATCGGTATCATCAAAAAAGATTAC
CCGCCGCAAGAGCCTTTTATTACGGCAACGATGACCGAAGTGGATCAATTAGCTGCCTTAAATATTGCAGTGATTGCTAT
GGATTGTACCAAGCGTGACCGACATGATGGCTTGGATATTGCTAGCTTTATTCGACAAGTTAAGGAAAAGTACCCCAATC
AGCTTTTGATGGCAGATATTAGTACCTTTGATGAAGGACTAGTGGCCCATCAGGCTGGCATTGATTTTGTTGGAACCACC
TTGTCAGGCTACACCCCGTATAGCCGTCAGGAAGCAGGTCCTGATGTGGCATTGATAGAAGCTCTTTGCAAAGCAGGCAT
TGCTGTCATTGCCGAAGGAAAGATTCATTTCCCAGAAGAAGCTAAGAAAATTAATGACTTAGGTGTGGCAGGTATTGTTG
TTGGAGGGGCCATCACAAGGCCTAAGGAAATTGCAGAGCGTTTTATCGAAGCGCTCAAATCCTAA

Protein sequence :
MPDKPTKEKLMEQLKGGIIVSCQALPGEPLYSETGGIMPLLAKAAQEAGAVGIRANSVRDIKEIQAITDLPIIGIIKKDY
PPQEPFITATMTEVDQLAALNIAVIAMDCTKRDRHDGLDIASFIRQVKEKYPNQLLMADISTFDEGLVAHQAGIDFVGTT
LSGYTPYSRQEAGPDVALIEALCKAGIAVIAEGKIHFPEEAKKINDLGVAGIVVGGAITRPKEIAERFIEALKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ef0066 AAM75271.1 EF0066 Not tested Not named Protein 2e-55 70
EF0540 NP_814312.1 N-acetylmannosamine-6-phosphate 2-epimerase Not tested Not named Protein 7e-67 69