Gene Information

Name : irbB (MGAS15252_0200)
Accession : YP_005388261.1
Strain : Streptococcus pyogenes MGAS15252
Genome accession: NC_017040
Putative virulence/resistance : Virulence
Product : prophage gene expression coactivator protein IbrB
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 177094 - 177624 bp
Length : 531 bp
Strand : +
Note : CDD hit: non-specific, cl2129 = ParB-like nuclease domain; Plasmid RK2 ParB preferentially cleaves single-stranded DNA. ParB also nicks supercoiled plasmid DNA preferably at sites with potential single-stranded character, like AT-rich regions and sequence

DNA sequence :
GTGAGTAATTTTATTAGTCCAGTCTATGAGATTAAATCAATTCCAATTGAAAAGATTTCTCCAAATGATTATAATCCGAA
TTCAGTTGCTCCGCCTGAAATGAAATTATTGTATGATAGTATAAAATCTGATGGTTATACTATGCCGATTGTTTGCTATT
ACGATAAGGAAGAGGATCGGTATAGTATTGTTGATGGTTTTCATAGATATCGTATAATGCTAGATTATTCAGATATTTAT
GAAAGGGAAAGTGGGAGATTACCTGTTTCTGTTATTGATAAGTCATTAGACTATCGAATGGCTTCTACCATTCGACATAA
TAGAGCTAGAGGAAGTCATGATGTTGATTTGATGAGTCAGATTGTAAAGGATCTTCATGAGTGTGGGCGAAGTGATAACT
GGATTGCAAAACATTTAGGAATGGATAAAGATGAAATTTTAAGACTGAAACAAATAACAGGATTGGCTTCTCTTTTTAAG
GACCATGAGTTTAATCAATCTTGGGAACCAGAAGAGTTATTAAATGAGTAA

Protein sequence :
MSNFISPVYEIKSIPIEKISPNDYNPNSVAPPEMKLLYDSIKSDGYTMPIVCYYDKEEDRYSIVDGFHRYRIMLDYSDIY
ERESGRLPVSVIDKSLDYRMASTIRHNRARGSHDVDLMSQIVKDLHECGRSDNWIAKHLGMDKDEILRLKQITGLASLFK
DHEFNQSWEPEELLNE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
M5005_Spy_0164 YP_281528.1 parB-like nuclease Not tested Not named Protein 7e-80 100
ef0120 AAM75321.1 EF0120 Not tested Not named Protein 3e-38 55
EF0607 NP_814365.1 ParB-like nuclease domain-containing protein Not tested Not named Protein 4e-38 55
STY4584 NP_458668.1 conserved hypothetical protein Not tested SPI-7 Protein 1e-28 47
t4278 NP_807876.2 hypothetical protein Not tested SPI-7 Protein 9e-29 47
Z1644 AAQ19140.1 putative ParB-like nuclease Not tested PAI I CL3 Protein 2e-29 46
ibrB ADD91736.1 predicted transcriptional regulator IbrB Not tested PAI-I AL862 Protein 2e-29 46
z1204 CAD33764.1 Z1204 protein Not tested PAI I 536 Protein 3e-29 46
Z1204 NP_286739.1 hypothetical protein Not tested TAI Protein 4e-29 45
Z1644 NP_287147.1 hypothetical protein Not tested TAI Protein 4e-29 45

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
irbB YP_005388261.1 prophage gene expression coactivator protein IbrB VFG1505 Protein 1e-29 46