Gene Information

Name : polA (MGAS15252_0195)
Accession : YP_005388256.1
Strain : Streptococcus pyogenes MGAS15252
Genome accession: NC_017040
Putative virulence/resistance : Unknown
Product : DNA-directed DNA polymerase I PolA/PolI
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 171287 - 173929 bp
Length : 2643 bp
Strand : +
Note : CDD hit: specific, cl2626 = Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Family A polymerase (polymerase I) functions primarily to fill DNA gaps that arise during DNA repair, recombination

DNA sequence :
ATGGAAAACAAGAATAAATTACTATTAATTGATGGGTCATCTGTTGCCTTTCGTGCCTTTTTTGCCCTTTACAATCAAAT
TGACCGCTTTAAAAACCATAGCGGTCTTCATACCAATGCCATTTATGGCTTTCATTTGATGCTAGACCACATGATGAAAA
GAGTCCAGCCTACTCACGTGCTGGTGGCTTTTGATGCGGGCAAAACCACCTTCCGAACAGAAATGTATGCTGATTATAAG
GCGGGTCGCGCCAAGACACCAGAGGAATTTCGTGAGCAGTTTCCTTATATTCGTGAGATGTTGACAGCCCTTGGGATTGC
TTATTATGAGTTGGAACACTACGAAGCAGACGATATTATCGGGACGCTTGATAAAATGGCGGAGCGCACAGAAGCGCCTT
TTGATGTGACCATTGTCAGTGGTGATAAAGATTTGATCCAGTTAACTGACGAAAATACCGTGGTTGAAATTTCTAAAAAA
GGGGTTGCCGAATTTGAAGAATTCACACCGGCTTACCTCATGGAAAAAATGGGCTTGACGCCAAACCAGTTTATTGACCT
CAAAGCCTTGATGGGAGATAAATCGGATAACATTCCTGGAGTGACAAAAATTGGAGAAAAAACAGGCCTTAAGCTCCTTC
ATGAATTTGGTAGTTTGGAAGGCATTTACGAGCATATTGATGGATTCAAGGCCTCAAAAATGAAAGAAAACTTGATCAAT
GACCGTGACCAAGCTTTCCTATCTAAAACGCTCGCCACTATCAATACAGCATCTCCTATCACAATTGGCTTAGATGATAT
TGTCTACAATGGTCCAGATGTTGCTAGCCTCTCTCAATTTTACGATGAGATGGATTTTGTGCAACTCAAGAAAGGTCTTG
CTAGCCAGATGCCTCAAGAGCCAGTAGCTGCCATTTCCTATCAAGAAGTGACCAATGTGTCTGCTGATTTGTTTAGCGCA
GAAGACATCTTCTACTTTGAAACGCTTCGGGATAATTACCATCGTGAGGCCATCATTGGTTTTGCTTGGGGACATGGTGA
GCAGATTTACGTATCCACTGACCTTAGCCTATTAGCGACGGATAGTTTTAAGCAGGTCTTTCAAAAACCCATTGCCACTT
ATGATTTTAAACGTAGCAAGGTCTTGTTGAGCCACTTAGGAATTGAGTTGGTAGCACCTAGCTATGATGCTAGATTAGCT
AATTACCTTCTGTCAACTGTAGAAGACAATGAGCTTAGCACCATTGCCCGCATTTTTACTGACATCTCTTTGGAAGAAGA
CGATACAGTCTATGGTAAAGGTGCTAAACGGGCTGTTCCTGATAAAGACGTTTTACTAGAACACTTAGCTCGTAAGGTCA
AAGTATTATTAGATAGCAAGTCTCAAATGCTAGACAAGCTCACTGCCCATGAGCAACTAGACCTCTATCAGAATATTGAA
TTGCCTTTGGCTAATGTCCTTGCTAAAATGGAAATTGAAGGGATCAAGGTTAATAGGGCGACTTTGCAAGATATGGCAGA
GCAAAACAAGGTCATTATTGAAGCGCTCACCCAAGAGATTTACGATATGGCTGGTCAAGAATTTAACATTAATTCGCCTA
AACAGCTGGGCAGTATCTTGTTTGAGAAGATGCAGTTACCTCTTGAGATGACTAAGAAGACCAAAACAGGTTATTCTACA
GCAGTGGATGTTTTGGAACGTTTGGCACCGATTGCTCCAATTGTGGCTAAAATTTTGGATTACCGCCAGATTACTAAATT
GCAATCCACTTATGTGATTGGTTTACAGGATTATATTCTGGCTGATGGCAAGATTCATACCCGCTATGTGCAGGATTTCA
CCCAGACAGGGCGTTTGTCTAGTGTGGACCCTAATCTTCAAAACATTCCTATTCGTTTGGAACAGGGGCGTTTGATTCGT
AAGGCCTTTACCCCATCTCATGAAGATGCCGTCTTGTTGAGTTCAGATTACTCACAGATTGAATTGCGGGTACTGGCACA
TATTTCAGGGGATGAGCATTTGATTGCTGCCTTTAATGAAGGGGCAGACATTCATACCTCAACGGCTATGCGTGTGTTTG
GGATTGACAAGGCAGCAGATGTTACTGCCAATGACCGCCGTAATGCCAAGGCTGTTAACTTTGGAATTGTGTATGGGATT
TCTGATTTTGGTTTGTCAAATAACCTTGGTATCACCCGTAAACAGGCCAAGTCTTACATTGATACCTATTTTGAACGCTA
TCCTGGGATTAAAGCCTATATGGAAAATGTGGTGCGTGAGGCTAAAGACAAGGGCTATGTAGAGACCCTCTTTAAGCGTC
GTCGTGAATTACCGGATATCAACTCTCGTAATTTCAACGTTCGCTCTTTTGCGGAGCGTACAGCCATCAACTCGCCCATT
CAAGGAAGCGCAGCTGATATTCTCAAAATCGCTATGATTAATCTGGATAAGGCCTTGCAAGCAGGTGGTTTTAGAGCTAA
AATGCTGCTTCAAGTGCATGATGAAATCGTTTTGGAAGTGCCAAATGATGAGTTGACTGCTATAAAAAAACTTGTCAAAG
ACACCATGGAAGCTGCTGTTGATTTAGCTGTTCCTTTATGTGTCGATGAAAGTACTGGGCAGAGCTGGTACGAAGCCAAA
TAA

Protein sequence :
MENKNKLLLIDGSSVAFRAFFALYNQIDRFKNHSGLHTNAIYGFHLMLDHMMKRVQPTHVLVAFDAGKTTFRTEMYADYK
AGRAKTPEEFREQFPYIREMLTALGIAYYELEHYEADDIIGTLDKMAERTEAPFDVTIVSGDKDLIQLTDENTVVEISKK
GVAEFEEFTPAYLMEKMGLTPNQFIDLKALMGDKSDNIPGVTKIGEKTGLKLLHEFGSLEGIYEHIDGFKASKMKENLIN
DRDQAFLSKTLATINTASPITIGLDDIVYNGPDVASLSQFYDEMDFVQLKKGLASQMPQEPVAAISYQEVTNVSADLFSA
EDIFYFETLRDNYHREAIIGFAWGHGEQIYVSTDLSLLATDSFKQVFQKPIATYDFKRSKVLLSHLGIELVAPSYDARLA
NYLLSTVEDNELSTIARIFTDISLEEDDTVYGKGAKRAVPDKDVLLEHLARKVKVLLDSKSQMLDKLTAHEQLDLYQNIE
LPLANVLAKMEIEGIKVNRATLQDMAEQNKVIIEALTQEIYDMAGQEFNINSPKQLGSILFEKMQLPLEMTKKTKTGYST
AVDVLERLAPIAPIVAKILDYRQITKLQSTYVIGLQDYILADGKIHTRYVQDFTQTGRLSSVDPNLQNIPIRLEQGRLIR
KAFTPSHEDAVLLSSDYSQIELRVLAHISGDEHLIAAFNEGADIHTSTAMRVFGIDKAADVTANDRRNAKAVNFGIVYGI
SDFGLSNNLGITRKQAKSYIDTYFERYPGIKAYMENVVREAKDKGYVETLFKRRRELPDINSRNFNVRSFAERTAINSPI
QGSAADILKIAMINLDKALQAGGFRAKMLLQVHDEIVLEVPNDELTAIKKLVKDTMEAAVDLAVPLCVDESTGQSWYEAK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
polA YP_281523.1 DNA polymerase I Not tested Not named Protein 0.0 99