Gene Information

Name : hasB (MGAS15252_1741)
Accession : YP_005389749.1
Strain : Streptococcus pyogenes MGAS15252
Genome accession: NC_017040
Putative virulence/resistance : Virulence
Product : UDP-glucose dehydrogenase protein HasB
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 1732094 - 1733302 bp
Length : 1209 bp
Strand : +
Note : CDD hit: non-specific, cl353 = UDP-glucose/GDP-mannose dehydrogenase family, central domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol

DNA sequence :
ATGAGAATAGCAGTTGCTGGATCAGGATATGTTGGATTATCACTAGGAGTTCTTTTATCACTTCAAAACGAAGTCACTAT
TGTTGATATTCTTCCCTCTAAAGTTGATAAGATTAATAATGGCTTATCACCAATTCAAGATGAATATATTGAAGATTACT
TAAAAAGTAAGCAATTATCTATTAAAGCAACTTTAGATAGCAAAGCAGCTTATAAAGAAGCGGAACTGGTCATTATTGCC
ACACCTACAAATTACAACAGTAGAATTAATTATTTTGATACACAGCATGTTGAAACAGTTATCAAAGAGGTACTAAGCGT
TAATAGCCATGCAACTCTTATCATCAAATCAACAATTCCAATAGGTTTCATTACTGAAATGAGACAGAAATTCCAAACTG
ATCGTATTATCTTCAGCCCTGAATTTTTAAGAGAATCTAAAGCTTTATATGACAACTTATATCCAAGCCGAATTATTGTT
TCTTGTGAAGAAAACGATTCTCCAAAAGTAAAGGCAGACGCAGAAAAATTTGCACTTTTATTAAAGTCTGCAGCTAAAAA
AAATAATGTACCAGTACTTATTATGGGAGCTTCAGAAGCTGAAGCAGTAAAACTATTTGCCAATACTTATTTAGCGTTAA
GGGTAGCTTATTTTAATGAGTTAGACACTTACGCAGAATCGAGAAAATTAAATAGTCACATGGTTATTCAAGGAATTTCT
TATGATGATCGAATAGGAATGCATTATAATAACCCATCATTTGGTTATGGAGGTTATTGTCTACCTAAAGATACGAAGCA
ATTATTGGCAAATTACAATAATATTCCCCAAACGCTAATTGAAGCTATCGTTTCATCAAATAATGTGCGCAAGTCCTATA
TTGCTAAGCAAATTATCAACGTCTTAGAAGAGCAGGAGTCCCCAGTAAAAGTAGTCGGGGTTTACCGTTTAATTATGAAA
AGTAACTCAGATAATTTTAGAGAAAGTGCTATCAAAGATGTTATTGACATTCTTAAAAGTAAAGACATTAAGATAATTAT
TTATGAGCCAATGTTAAACAAACTTGAATCTGAAGATCAATCTGTACTTGTAAATGATTTAGAGAATTTCAAGAAACAAG
CAAATATTATCGTAACTAATCGCTATGATAATGAATTACAAGATGTTAAAAATAAAGTTTACAGTAGAGATATTTTTGGT
AGAGACTAG

Protein sequence :
MRIAVAGSGYVGLSLGVLLSLQNEVTIVDILPSKVDKINNGLSPIQDEYIEDYLKSKQLSIKATLDSKAAYKEAELVIIA
TPTNYNSRINYFDTQHVETVIKEVLSVNSHATLIIKSTIPIGFITEMRQKFQTDRIIFSPEFLRESKALYDNLYPSRIIV
SCEENDSPKVKADAEKFALLLKSAAKKNNVPVLIMGASEAEAVKLFANTYLALRVAYFNELDTYAESRKLNSHMVIQGIS
YDDRIGMHYNNPSFGYGGYCLPKDTKQLLANYNNIPQTLIEAIVSSNNVRKSYIAKQIINVLEEQESPVKVVGVYRLIMK
SNSDNFRESAIKDVIDILKSKDIKIIIYEPMLNKLESEDQSVLVNDLENFKKQANIIVTNRYDNELQDVKNKVYSRDIFG
RD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SSP0068 YP_300158.1 UDP-glucose 6-dehydrogenase Not tested SCC15305cap Protein 3e-70 51

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
hasB YP_005389749.1 UDP-glucose dehydrogenase protein HasB VFG0963 Protein 9e-157 99