Gene Information

Name : cmlA (COCOR_02270)
Accession : YP_005368258.1
Strain : Corallococcus coralloides DSM 2259
Genome accession: NC_017030
Putative virulence/resistance : Resistance
Product : Bcr/CflA family protein drug resistance transporter
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 2731627 - 2732814 bp
Length : 1188 bp
Strand : +
Note : -

DNA sequence :
ATGTCTGACCCCAAAGCCCTGTCGTGGAATCACACCGTGCCAGCAGCGCTGTTGCTGATGGCCCCCTTCGACCTCCTGGC
CTCGCTGGCCATGGACATCTACCTCCCCGTGGTCCCGGCCATGACCGGAGTCCTCGGCACCTCTCCCTCCATCATCCAGC
TCACGCTGAGCCTCTACATGGCCATTCTCGGGGCCGGGCAGCTGGTGTTCGGCCCGCTCTCCGACCGCATCGGCCGGCGC
AGGGTGTTGCTGGGGGGCGCGTGGGTGTTCGCGACCACCTCCTTCCTGCTCGCGGGCACCACCGATGCCGCGATGTTCGT
CGGGCTCCGGCTCCTGCAAGCCGTGGGGGCCTCCGCGGCGCTCGTCGCGACGTTCGCCACCGTCCGGGACGTCTATGCGG
AGCGGCCCGAAGGCACGGTCATCTACAGCCTGTTCAGCGCCATTCTGGCCTTCGTTCCGGCACTGGGCCCCATCGCCGGG
GCCCTGCTCGCGCGGCACTTCGGATGGCGGGCCCTCTTCGTCACGCTCGGCGTCCTGGCGACGGCGGCGTTGCTCCAGGC
CCTGCCGCGCTGGCCTGAGACACGTCCCTCCGGCGTGGCCCGTCAGACGGTGTCCGTCCAGCACATCCTGCGCAGCGGCG
CGTTCTGGACGTACACGCTGGGCTTCAGCGCGGCCATGGGCTCCTTCTTCGTGTTCTTCTCCACGGCGCCCCGGGTGCTC
ATGGGACGGGCCGGCTTCTCGGAGCTTGGCTTCAGCCTGGCCTTCGCCACCGCCGCGCTGGCCATGATGGTGACCACGCG
CTTCGCGAAGCACCTCGTGGCCCGCTGGGGGCTGGCGGGAAGCCTTGCCCGCGGCATGCTCCTGCTGCTGCTGGGCGCGG
TGTTGCTCACCGCCGGGCAGCTCCTCACGGCGCCGTCCTTCTGGACGTTCGTCGTGCCCATGTGGGTCATCGCCGCGGGG
ATTGTCTTCGCCGTCTCCGTCACCGCCAATGGCGCGCTCCAGGCCTTTGGCGCCGTGGCGGGAACGGCGGTCGCGCTCTA
CTTCTGCATCCAGAGCCTCGTCGTCGCCGTCGTGGGGACCCTGATGGTCGTCCTGCTCGACGGCGACACCGCGTGGCCCC
TGGTGGGGTACGCCTCGCTCATGGCGGGGGTGACGTTGGGCTGCCTGGCATCCTTCAAGCGCCCCTAG

Protein sequence :
MSDPKALSWNHTVPAALLLMAPFDLLASLAMDIYLPVVPAMTGVLGTSPSIIQLTLSLYMAILGAGQLVFGPLSDRIGRR
RVLLGGAWVFATTSFLLAGTTDAAMFVGLRLLQAVGASAALVATFATVRDVYAERPEGTVIYSLFSAILAFVPALGPIAG
ALLARHFGWRALFVTLGVLATAALLQALPRWPETRPSGVARQTVSVQHILRSGAFWTYTLGFSAAMGSFFVFFSTAPRVL
MGRAGFSELGFSLAFATAALAMMVTTRFAKHLVARWGLAGSLARGMLLLLLGAVLLTAGQLLTAPSFWTFVVPMWVIAAG
IVFAVSVTANGALQAFGAVAGTAVALYFCIQSLVVAVVGTLMVVLLDGDTAWPLVGYASLMAGVTLGCLASFKRP

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cmlA9 ABZ01840.1 CmlA9 chloramphenicol efflux protein Not tested SGI2 Protein 2e-87 68
cmlA CAJ77032.1 chloramphenicol and florfenicol resistance protein Not tested AbaR1 Protein 2e-87 68
flo AAK02049.1 chloramphenicol and florfenicol resistance protein Not tested SGI1 Protein 2e-86 67
floRc AGK06972.1 chloramphenicol and florfenicol resistance protein Not tested SGI1 Protein 2e-86 67
floRc AGK07102.1 chloramphenicol and florfenicol resistance protein Not tested SGI1 Protein 2e-86 67
floR YP_005176183.1 florfenicol / chloramphenicol efflux protein Not tested ICEPmu1 Protein 4e-86 67
cml(A)5 ACY75522.1 CmLA(5) Not tested Tn6060 Protein 2e-66 51
cmlA5 CAJ77046.1 Chloramphenicol resistance protein Not tested AbaR1 Protein 2e-66 51

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cmlA YP_005368258.1 Bcr/CflA family protein drug resistance transporter DQ984668.gene.p01 Protein 1e-66 51
cmlA YP_005368258.1 Bcr/CflA family protein drug resistance transporter AF294653.1.gene4.p01 Protein 9e-67 51
cmlA YP_005368258.1 Bcr/CflA family protein drug resistance transporter DQ522237.1.gene4.p01 Protein 1e-66 51
cmlA YP_005368258.1 Bcr/CflA family protein drug resistance transporter NC_010410.6003586.p0 Protein 1e-66 51
cmlA YP_005368258.1 Bcr/CflA family protein drug resistance transporter AF156486.gene.p01 Protein 4e-65 50