Gene Information

Name : mbtA (NOCYR_0626)
Accession : YP_005262085.1
Strain : Nocardia cyriacigeorgica GUH-2
Genome accession: NC_016887
Putative virulence/resistance : Virulence
Product : 2,3-dihydroxybenzoate-AMP ligase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 673943 - 675583 bp
Length : 1641 bp
Strand : -
Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10688898; Product type e : enzyme

DNA sequence : 
GTGAGTTCCACTTCCACCGCATCCGGCACCCACCGCGATGGCTATGTGCCGTTTTCCGAGGCCGAGGCCGAGCAGTACCG
CGCCGCCGGATACTGGTCCGGGCGCACGCTCGACGGCCTGTTGCGCGACACCGCCCGGCAGCATCCCGCCCGCACCGCGC
TGATCGGCGAGCGCCCGCTCAGCTACGCCGAGCTCGACGCCGAAGCCGAGCGGATGGCGCACGGCCTGCTCGCGCTCGGG
CTGGAACCGGGCGACCGGGTGGTGGTTCAGCTGCCCAATGTCGCCGAATTCCTGACCGTGCTGTTCGGTGTGCTACGCGC
CGGCATCATCCCGGTGCTCACCCTGCCCGCGCACCGCCGCGCCGAGATCGAACATCTGGCCACCCTGTCCGGCGCGGTCG
CGTACGTGATCGCCGATCAGGCAGGCGATTTCGACTATCGCGAGCTGGCCGCCACGGTCCGCGCGAACGTGCCGAGCCTG
CGTCATGTGCTCGTGCTCGGCGACCCGGGCGAATTCACCGCCTTGGATTCGATTCCGGCGCAGGGCGATACCCGTGCGGC
CGGCGGCGCGAGCCTGCCCGAGATCGATCCGTCCGATATCGCACTGATGCTCGTCTCCGGCGGCACCACCGGGCTGCCCA
AGCTGATCGCCCGCACCCACGACGACTACGTCTACAACGCGACGGCGAGCGCGCAGGTCTGCGAACTCACCTCAGACGAC
GTCTACCTGGCGACGCTGCCCGCCGCGCACAACTTCCCGCTGGCTTGCCCCGGCATCCTCGGCACCGTCAGCGTCGGCGG
GGCGGTGGCCTTCGTCGCGGATCCGAGCCCGGAGAACGCCTTCGCCGTCATCGAGACCCATCGCGTGACGGTGACGGCGG
TGGTCCCGCCGCTGGCCCAGCTGTGGTGCGCGGCCGTGGAATGGGAGGAACCCGACCTGAGTTCGCTGCGCCTGCTCCAG
GTGGGCGGGGCGAAGCTGGCCGAGGTCAATGCCCGCGAGGTGGCGCCCGCCTTGGGCGTGCGGTTGCAGCAGGTGTTCGG
CATGGCCGAGGGGCTGCTCAACTTCACCCGGCTCGACGATTCCGATGAGCTCATCTGCACCACCCAGGGCCGTCCGCTCT
CCCCCGCCGACATCGTGCGCGTGGTCGACGCCGAGGGCAACGACGTGGCGCCGGGCGAGGAAGGTGAGCTGCTCACCAAG
GGTCCGTACACGATTCGCGGGTACTACCGCGCGCCCGAGCACAATGCCCGGGCCTTCACTCCCGACGGGTTCTACCGCAG
CGGCGACCTGGTGCGGAAGCTGCCCAGCGGGCATCTGGTGGTCTCCGGCCGGATCAAGGACGTCATCAATCGCGGCGGCG
AGAACATCTCCTGCGACGAACTCGAGGAACACCTGCTGGCCCATCCGGCAGTCCGGCACGCGGCCGCCGTCGGCCTGCCC
GATCCGAGTCTCGGCGAGAAGGTCTGCGCGGTGCTGGTGGTGCACGGGGAGATGCCGACGCTGGTGCAGATCAAGACCTT
CCTCACCGAACGCGGCCTGGCCACCTACAAACTGCCCGACGTGCTGCGTCAGGCCGAGAGCCTGCCGGTGACGGCGGTCG
GCAAGATCGACAAGAAGGCGTTGCAGGCCGCCGAGGGCTGA

Protein sequence : 
MSSTSTASGTHRDGYVPFSEAEAEQYRAAGYWSGRTLDGLLRDTARQHPARTALIGERPLSYAELDAEAERMAHGLLALG
LEPGDRVVVQLPNVAEFLTVLFGVLRAGIIPVLTLPAHRRAEIEHLATLSGAVAYVIADQAGDFDYRELAATVRANVPSL
RHVLVLGDPGEFTALDSIPAQGDTRAAGGASLPEIDPSDIALMLVSGGTTGLPKLIARTHDDYVYNATASAQVCELTSDD
VYLATLPAAHNFPLACPGILGTVSVGGAVAFVADPSPENAFAVIETHRVTVTAVVPPLAQLWCAAVEWEEPDLSSLRLLQ
VGGAKLAEVNAREVAPALGVRLQQVFGMAEGLLNFTRLDDSDELICTTQGRPLSPADIVRVVDAEGNDVAPGEEGELLTK
GPYTIRGYYRAPEHNARAFTPDGFYRSGDLVRKLPSGHLVVSGRIKDVINRGGENISCDELEEHLLAHPAVRHAAAVGLP
DPSLGEKVCAVLVVHGEMPTLVQIKTFLTERGLATYKLPDVLRQAESLPVTAVGKIDKKALQAAEG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 1e-112 50
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 2e-112 50
ybtE CAA21394.1 - Virulence HPI Protein 8e-114 50
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 6e-114 50
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 9e-114 50
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 8e-114 50
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 8e-114 50
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 8e-114 50
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 8e-114 50

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
mbtA YP_005262085.1 2,3-dihydroxybenzoate-AMP ligase VFG1817 Protein 1e-143 58
mbtA YP_005262085.1 2,3-dihydroxybenzoate-AMP ligase VFG0168 Protein 2e-107 48
mbtA YP_005262085.1 2,3-dihydroxybenzoate-AMP ligase VFG0932 Protein 2e-102 46