Gene Information

Name : hilA (STMUK_2865)
Accession : YP_005253365.1
Strain : Salmonella enterica UK-1
Genome accession: NC_016863
Putative virulence/resistance : Virulence
Product : invasion protein regulator
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 2988346 - 2990007 bp
Length : 1662 bp
Strand : +
Note : Activates the expression of invasion genes and activates the expression of prgHIJK which is part of the pathogenicity island 1 type III secretion system

DNA sequence :
ATGCCACATTTTAATCCTGTTCCTGTATCGAATAAAAAATTCGTCTTTGATGATTTCATACTCAACATGGACGGCTCCCT
GCTACGCTCAGAAAAGAAAGTCAATATTCCGCCAAAAGAATATGCCGTTCTGGTCATCCTGCTCGAAGCCGCCGGCGAGA
TTGTGAGTAAAAACACCTTACTGGACCAGGTATGGGGCGACGCGGAAGTTAACGAAGAATCTCTTACCCGCTGTATTTAT
GCCTTACGACGTATTCTGTCGGAAGATAAAGAGCATCGTTACATTGAAACACTGTACGGACAGGGCTATCGGTTTAATCG
TCCGGTCGTAGTGGTGTCTCCGCCAGCGCCGCAACCTACGACTCATACATTGGCGATACTTCCTTTTCAGATGCAGGATC
AGGTTCAATCCGAGAGTCTGCATTACTCTATCGTGAAGGGATTATCGCAGTATGCGCCCTTTGGCCTGAGCGTGCTGCCG
GTGACCATTACGAAGAACTGCCGCAGTGTTAAGGATATTCTTGAGCTCATGGATCAATTACGCCCCGATTATTATATCTC
CGGGCAGATGATACCCGATGGTAATGATAATATTGTACAGATTGAGATAGTTCGGGTTAAAGGTTATCACCTGCTGCACC
AGGAAAGCATTAAGTTGATAGAACACCAACCCGCTTCTCTCTTGCAAAACAAAATTGCGAATCTTTTGCTCAGATGTATT
CCCGGACTTCGCTGGGACACAAAGCAGATTAGCGAGCTAAATTCGATTGACAGTACTATGGTTTACTTACGCGGTAAGCA
TGAGTTAAATCAATACACCCCCTATAGCTTACAGCAAGCGCTTAAATTGCTGACTCAATGCGTTAACATGTCGCCAAACA
GCATTGCGCCTTACTGTGCGCTGGCAGAATGCTACCTCAGCATGGCGCAAATGGGGATTTTTGATAAACAAAACGCTATG
ATCAAAGCTAAAGAACATGCGATTAAGGCGACAGAGCTGGACCACAATAATCCACAAGCTTTAGGATTACTGGGGCTAAT
TAATACGATTCACTCAGAATACATCGTCGGGAGTTTGCTATTCAAACAAGCTAACTTACTTTCGCCCATTTCTGCAGATA
TTAAATATTATTATGGCTGGAATCTTTTCATGGCTGGTCAGTTGGAGGAGGCCTTACAAACGATTAACGAGTGTTTAAAA
TTGGACCCAACGCGCGCAGCCGCAGGGATCACTAAGCTGTGGATTACCTATTATCATACCGGTATTGATGATGCTATACG
TTTAGGCGATGAATTACGCTCACAACACCTGCAGGATAATCCAATATTATTAAGTATGCAGGTTATGTTTCTTTCGCTTA
AAGGTAAACATGAACTGGCACGAAAATTAACTAAAGAAATATCCACGCAGGAAATAACAGGACTTATTGCTGTTAATCTT
CTTTACGCTGAATATTGTCAGAATAGTGAGCGTGCCTTACCGACGATAAGAGAATTTCTGGAAAGTGAACAGCGTATAGA
TAATAATCCGGGATTATTACCGTTAGTGCTGGTTGCCCACGGCGAAGCTATTGCCGAGAAAATGTGGAATAAATTTAAAA
ACGAAGACAATATTTGGTTCAAAAGATGGAAACAGGATCCCCGCTTGATTAAATTACGGTAA

Protein sequence :
MPHFNPVPVSNKKFVFDDFILNMDGSLLRSEKKVNIPPKEYAVLVILLEAAGEIVSKNTLLDQVWGDAEVNEESLTRCIY
ALRRILSEDKEHRYIETLYGQGYRFNRPVVVVSPPAPQPTTHTLAILPFQMQDQVQSESLHYSIVKGLSQYAPFGLSVLP
VTITKNCRSVKDILELMDQLRPDYYISGQMIPDGNDNIVQIEIVRVKGYHLLHQESIKLIEHQPASLLQNKIANLLLRCI
PGLRWDTKQISELNSIDSTMVYLRGKHELNQYTPYSLQQALKLLTQCVNMSPNSIAPYCALAECYLSMAQMGIFDKQNAM
IKAKEHAIKATELDHNNPQALGLLGLINTIHSEYIVGSLLFKQANLLSPISADIKYYYGWNLFMAGQLEEALQTINECLK
LDPTRAAAGITKLWITYYHTGIDDAIRLGDELRSQHLQDNPILLSMQVMFLSLKGKHELARKLTKEISTQEITGLIAVNL
LYAEYCQNSERALPTIREFLESEQRIDNNPGLLPLVLVAHGEAIAEKMWNKFKNEDNIWFKRWKQDPRLIKLR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hilA YP_217795.1 invasion protein regulator Virulence SPI-1 Protein 0.0 100
hilA NP_461797.1 invasion protein regulator Virulence SPI-1 Protein 0.0 100
iagA NP_806479.1 invasion protein regulator Virulence SPI-1 Protein 0.0 99
iagA NP_457270.1 invasion protein regulator Not tested SPI-1 Protein 0.0 99

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
hilA YP_005253365.1 invasion protein regulator VFG0538 Protein 0.0 100