Gene Information

Name : guaA (STM14_3075)
Accession : YP_005238603.1
Strain : Salmonella enterica 14028S
Genome accession: NC_016856
Putative virulence/resistance : Unknown
Product : bifunctional GMP synthase/glutamine amidotransferase protein
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 2674357 - 2675934 bp
Length : 1578 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACGGAAAACATTCATAAGCATCGCATCCTCATTCTGGACTTCGGTTCTCAGTACACTCAACTGGTTGCGCGCCGCGT
GCGTGAGCTGGGTGTTTACTGTGAACTGTGGGCGTGGGATGTGACAGAAGCACAAATTCGTGACTTCAACCCAAGCGGCA
TTATTCTTTCCGGCGGCCCGGAAAGCACCACCGAAGAAAACAGCCCGCGCGCGCCGCAGTATGTCTTTGAAGCAGGCGTG
CCGGTATTTGGCGTTTGCTATGGTATGCAGACCATGGCGATGCAGCTTGGCGGTCATGTAGAAGGTTCTAATGAGCGTGA
ATTTGGTTATGCGCAGGTCGAAGTGTTGACCGACAGCGCGCTGGTTCGCGGTATTGAAGATTCCCTGACCGCAGACGGCA
AACCGCTGCTGGACGTGTGGATGAGCCACGGCGATAAAGTGACGGCGATTCCGTCCGACTTCGTGACCGTCGCCAGCACC
GAGAGCTGCCCGTTCGCCATTATGGCCAACGAAGAAAAACGCTTCTACGGTGTACAGTTCCACCCGGAAGTGACTCACAC
CCGCCAGGGTATGCGCATGCTGGAGCGTTTTGTACGCGATATCTGCCAGTGTGAAGCGTTGTGGACGCCGGCGAAGATCA
TCGACGACGCCGTGGCGCGCATTCGCGAGCAGGTGGGCGACGACAAAGTGATCCTCGGCCTCTCTGGTGGCGTGGATTCT
TCCGTCACCGCAATGCTGCTGCACCGCGCGATCGGTAAAAATCTGACCTGTGTATTCGTCGACAACGGCCTGCTGCGTCT
CAACGAAGCCGAGCAGGTGATGGACATGTTTGGCGACCATTTTGGCCTGAATATCGTTCACGTACCGGCAGAAGAGCGCT
TCCTGTCCGCGCTGGCTGGCGAGAACGATCCGGAAGCCAAGCGTAAGATCATCGGTCGTGTTTTTGTAGAAGTGTTCGAC
GAAGAAGCGCTCAAACTGGAAGACGTGAAGTGGCTGGCGCAAGGCACCATTTACCCTGACGTTATCGAATCTGCGGCGTC
TGCAACCGGTAAAGCGCACGTCATCAAATCTCACCACAATGTCGGCGGCTTGCCGAAAGAGATGAAGATGGGGCTGGTTG
AACCGCTGAAAGAGCTGTTCAAAGACGAAGTGCGTAAGATTGGTCTGGAGCTGGGCCTGCCGTATGACATGCTGTATCGC
CATCCGTTCCCGGGGCCGGGCCTCGGCGTTCGTGTTCTGGGTGAAGTGAAGAAAGAGTACTGCGACCTGCTGCGCCGTGC
TGACGCTATCTTCATTGAAGAGCTGCGCAAAGCGGATCTGTACGACAAAGTCAGTCAGGCGTTTACCGTCTTCCTGCCGG
TTCGTTCCGTTGGCGTTATGGGCGATGGTCGTAAGTATGACTGGGTTGTCTCTCTGCGTGCCGTCGAAACCATCGACTTT
ATGACCGCACACTGGGCGCACCTGCCGTATGACTTCCTCGGTCGCGTTTCCAACCGCATCATCAATGAAGTCAACGGGAT
TTCCCGTGTGGTGTATGACATCAGCGGTAAACCGCCGGCTACCATTGAGTGGGAATAA

Protein sequence :
MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGGPESTTEENSPRAPQYVFEAGV
PVFGVCYGMQTMAMQLGGHVEGSNEREFGYAQVEVLTDSALVRGIEDSLTADGKPLLDVWMSHGDKVTAIPSDFVTVAST
ESCPFAIMANEEKRFYGVQFHPEVTHTRQGMRMLERFVRDICQCEALWTPAKIIDDAVARIREQVGDDKVILGLSGGVDS
SVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVMDMFGDHFGLNIVHVPAEERFLSALAGENDPEAKRKIIGRVFVEVFD
EEALKLEDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRKADLYDKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
MTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-127 51
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 9e-128 51
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 7e-128 51
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-110 48