Gene Information

Name : topB2 (HIB_00900)
Accession : YP_005178125.1
Strain : Haemophilus influenzae 10810
Genome accession: NC_016809
Putative virulence/resistance : Unknown
Product : DNA topoisomerase III
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 97115 - 99160 bp
Length : 2046 bp
Strand : +
Note : -

DNA sequence :
ATGAAATTATTTTTATGTGAAAAACCATCACAAGGCAATGATATTGCAAAAGTATTAGGTGCGACAAAGCGTGGTGAGGG
TTGTTTATCAACACCTGACGGTCAGCTTACAGTTACCTGGGGAATTGGTCATCTAGTAGAGCAATTTAATCCTGAAGAAT
ATGATCCTGCCTTTAAAAAGTGGGCATTTGAGACCTTGCCAATTATCCCGGGTAAATGGGGGCTTTCACCTAAAAAAGAA
ACAAAAAAACAGTTCAATGTCGTCATGAAACTTATCAAACAAGCTAAACTTGTTGTCATTGCAACCGATATTGATAGAGA
GGGCGAAACTATAGCAAGAGAATTGCTGGATTTGGCAGGATTTCGAGGGCAAATAAAACGCCTTTGGTTGTCTGCACTAG
ATGATACCAGTATTCGCAAAGCCTTGGGCGCACTTAAAAATAATGAGGAGACACTACCTCTTTACTATGCGGGACTTGCA
CGTAGTCGAGCTGATTGGCTTATTGGTATGAATTTCTCTCGTCTCTATACCTTATTAGCGCAACAACAAGGGTATCAAGG
GAAACCTTTAAGTGTTGGTCGGGTACAAACTCCAACATTAAGCTTGGTTGTTAATCGTGACCGTGAGATAAAAAACTTCA
TTCCTAAGCAACATTTTGCTTTGCAAGTAATGCTTTCTGATGGAAATCAGCATTTTGCTACGCAATATGTTATTCCGGAG
CAATATTGTGATCCTGATGGACTTTGTTTGTCTGCCCAAGTTATACAAGCAGCAAATCAGCAAATTCGCCAATTTGGCCA
AGCGAAAGTGGAATCAGTTGAAACTAAACGTGAAAGACAAAATGCCCCACTTTGCTTTGCATTAAGTGACTTACAATCAG
AAGCTAACCGCCTTTATGGACTGGGTGCGCAAAGAGTATTGGATATAGCTCAATCACTTTATGAGACTCACAAAGCGACA
ACCTATCCTAGAACAGATTGTGGTTATTTACCGGAGTCTCAGTTTGCAGAAGCGCCTCAAATTATCCAATGTTTGTTGCA
ATCCGATAATCGATTACACCCCCTTGCAGGTATGTTAAACCTTAATCAAAAATCACGAGTTTGGAATGATAAAAAAATTA
CTGCTCACCATGGCATTATTCCGACTATGATTAAAGCTGATATTAGCAAAATGTCTGATGAAGAATTAAAGCTCTATGAT
CTCATACGTCGTCGTTATTTAGCTCAATTCTTACCTGTTTCTGAAACAGATAAGACACAAATTATTTTGAAGTGCGGTCA
ACATATATTAAGTGCACGTGGGAATGTGCTTATTGCTCCAGGTTGGAAAATTCTATTTGGCAAATCACTTGATGAAGATG
ATGACGCACCTCAAGCCTTGCCGACGTTAAAGCAAGGACAAATCTGTCAGATTTCTGATTCAGAAATAAAAACCTTACAA
ACATCACCACCTAATCACTTCACGGAAGGTACATTGCTCACCGCAATGAAAAATGCAGCTCGCTTTGTAACTGATGAGCG
TTTAAAACAACGCTTACGAGAAACTGAAGGGCTTGGAACAGAAGCTACTCGGGCGGGAACGATTCAAGGTTTGATTGATA
AAGGTTTCTTGAAAAAGAAAGGTAAATCACTATTAGCGACAGATGAAGCAATGACGCTAATTGATAATTTACCTCAGATG
TTAAAAGATCCGGGTTTAACCGCACTTTGGGAGCAAGCGCTCAATCAAATTGCTGAAAGAACGCTTTCGCTAGAAGTGTT
TATGCAAAAACAAGAAGTCTTTGTGCGGCATTTGATGGCTGATTGCCTTAAAAAGGGAATGAGTTTGGGGAATATTGAAA
TTCGTAAATGCCCTAAGTGCGGTGCACCAATGATTAAAAGAAATGGTAAAAATGGGGCTTTTTTTGGGTGTTCTGCTTAT
CCAAATTGCCAACATATTGAAAATATTGATAGCAAGAAGAATACTAAAAGTACAAAAAATTTAAAGAAAAAGTCGAGTAA
AAGTGTGAGTGAGCAAATTTCATCTTTACGAAGCTTATTGAACTAG

Protein sequence :
MKLFLCEKPSQGNDIAKVLGATKRGEGCLSTPDGQLTVTWGIGHLVEQFNPEEYDPAFKKWAFETLPIIPGKWGLSPKKE
TKKQFNVVMKLIKQAKLVVIATDIDREGETIARELLDLAGFRGQIKRLWLSALDDTSIRKALGALKNNEETLPLYYAGLA
RSRADWLIGMNFSRLYTLLAQQQGYQGKPLSVGRVQTPTLSLVVNRDREIKNFIPKQHFALQVMLSDGNQHFATQYVIPE
QYCDPDGLCLSAQVIQAANQQIRQFGQAKVESVETKRERQNAPLCFALSDLQSEANRLYGLGAQRVLDIAQSLYETHKAT
TYPRTDCGYLPESQFAEAPQIIQCLLQSDNRLHPLAGMLNLNQKSRVWNDKKITAHHGIIPTMIKADISKMSDEELKLYD
LIRRRYLAQFLPVSETDKTQIILKCGQHILSARGNVLIAPGWKILFGKSLDEDDDAPQALPTLKQGQICQISDSEIKTLQ
TSPPNHFTEGTLLTAMKNAARFVTDERLKQRLRETEGLGTEATRAGTIQGLIDKGFLKKKGKSLLATDEAMTLIDNLPQM
LKDPGLTALWEQALNQIAERTLSLEVFMQKQEVFVRHLMADCLKKGMSLGNIEIRKCPKCGAPMIKRNGKNGAFFGCSAY
PNCQHIENIDSKKNTKSTKNLKKKSSKSVSEQISSLRSLLN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
topB1 YP_005176228.1 DNA topoisomerase III Not tested ICEPmu1 Protein 0.0 68
pph56 CAI36097.1 Topoisomerase IA Not tested PPHGI-1 Protein 3e-158 52
topB AAN62194.1 putative DNA topoisomerase III Not tested PAGI-2(C) Protein 2e-162 52
topB NP_458624.1 topoisomerase B Not tested SPI-7 Protein 1e-153 51
topB NP_807836.1 DNA topoisomerase III Not tested SPI-7 Protein 1e-153 51
topB AAF14809.1 topoisomerase B Not tested SPI-7 Protein 9e-154 51
topB AAN62317.1 putative DNA topoisomerase III Not tested PAGI-3(SG) Protein 3e-152 50
PMI2630 YP_002152332.1 DNA topoisomerase III Not tested Not named Protein 1e-143 47