Gene Information

Name : merA (CDHC02_0068)
Accession : YP_005163857.1
Strain : Corynebacterium diphtheriae HC02
Genome accession: NC_016802
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : -
COG ID : -
EC number : 1.16.1.1
Position : 68877 - 70319 bp
Length : 1443 bp
Strand : -
Note : Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

DNA sequence :
ATGCCTGACGTAGCACCAGATTTTGATTTAGCCGTGATCGGTTCCGGAGGCGGCGCCTTCGCCGCCGCCATCCGGGCCAC
CAAGCTGGGCAATCGGGTCGTGATGATCGAACGCTCCACGGTGGGCGGGACCTGTGTGAACACCGGGTGCGTTCCCTCCA
AAGCCCTGCTGGCCGCCGCCGAAGCCCGGCATGTCGCTGTGGATGCGACCGGAAGGTTCCCCGGGATCAGCACTTCCGCC
GCCCCGGTGGACATGGGTGTACTGATAGACGGGAAACGCTCCCTGGTCGAGGGAATGCGCTCGGATAAATACGTGGATCT
GGCCGCCGACTACGGATGGGACCTGCGCCAGGGCACCGCGGTGTTCGCCGGCACCCCGGAGGAACCGGTCCTGGAAATCA
CCGGACCCGACGGCACCCGCGACTCCCTGACCGCCGCCCATTATCTGGTCGCGACCGGTTCGACCCCGTGGGCACCCCCG
GTGCCGGGACTGGATGAAGTCAACTACCTGACCTCGACCACCGCCATGGAACTGAACGAGGTGCCCGAGTCCCTGATCGT
CTTCGGCGGCGGGTACGTGGCCCTGGAGCAGGCGCAGCTTTTTGCCCGCCTCGGATCCAAAGTGACCTTGCTGGTCCGCT
CCAGGCTTGCCTCGCACGAGGAACCGGAAGCTTCCCGTGCGCTGATGGGCGTCTTCGCCGACGAGGGCATCCGCGTGGTC
CGCCGCGCAGCCGTAACTTCGGTCCGCACAGATCCCGCCGGCGCAGAGGTCCTTGTCACCGCCACGGTCGCCGGGGGCCA
GGAGGAATTCCGCGCCGCAAAGCTGCTGGTAGCCACCGGCCGACGCGCCGTCACCGACGGACTGAACCTGGACGCCGTCG
GCGTCAAGACCGGCGACGCCGGCCAGATCCTGGTCGAGAGCACACTCGCCAGCTCCAACCCCAGGATCTGGGCCGCAGGG
GATGTGACCGGGCACCGAGAATTCGTCTACGTCGCGTCCGCCCACGGAACCCTGATGGTGGAGAACGCCTTCAACAACGC
CGGGCGCGAGGTCGACTACCGGCACCTGCCCCGCGTGACGTTCACCAGCCCGTCACTGGCCGCGGTCGGCATGACCGACA
AGGAAGCCAACGAGGCGGGCATCCGGTGTGAATGCCGGGTCCTGCCCCTGGAATACGTTCCCCGGGCACTGGTGAACCGG
GACACCCGCGGCTTCATCAAAATCGTCGCCGACGCCGACACCGGACGGATTGTGGGGATCACCGCCGTCGGCAAGGAGGC
CGGTGACCTGGCCGCCGCCGGAGTCTACATCCTCGAGGCCGGCATGACCGTTGACCAGGTCGCGAACCTCTGGTGCCCAT
ACCTGACCATGGCCGAAGGGATCAAAATCGCCGCACAGTCCTTCACCACCGACGTCTCCAAACTCTCCTGCTGCGCCTCC
TGA

Protein sequence :
MPDVAPDFDLAVIGSGGGAFAAAIRATKLGNRVVMIERSTVGGTCVNTGCVPSKALLAAAEARHVAVDATGRFPGISTSA
APVDMGVLIDGKRSLVEGMRSDKYVDLAADYGWDLRQGTAVFAGTPEEPVLEITGPDGTRDSLTAAHYLVATGSTPWAPP
VPGLDEVNYLTSTTAMELNEVPESLIVFGGGYVALEQAQLFARLGSKVTLLVRSRLASHEEPEASRALMGVFADEGIRVV
RRAAVTSVRTDPAGAEVLVTATVAGGQEEFRAAKLLVATGRRAVTDGLNLDAVGVKTGDAGQILVESTLASSNPRIWAAG
DVTGHREFVYVASAHGTLMVENAFNNAGREVDYRHLPRVTFTSPSLAAVGMTDKEANEAGIRCECRVLPLEYVPRALVNR
DTRGFIKIVADADTGRIVGITAVGKEAGDLAAAGVYILEAGMTVDQVANLWCPYLTMAEGIKIAAQSFTTDVSKLSCCAS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 3e-86 44
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 4e-86 44
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 4e-68 43
merA AGK07021.1 MerA Not tested SGI1 Protein 1e-68 42
merA AGK07079.1 MerA Not tested SGI1 Protein 1e-68 42
merA ABQ57371.1 MerA Not tested SGI1 Protein 1e-68 42
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 3e-67 42
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 4e-67 42
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 6e-67 41
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 5e-67 41
merA AFG30120.1 MerA Not tested PAGI-2 Protein 5e-67 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
merA YP_005163857.1 mercuric reductase BAC0224 Protein 5e-83 46
merA YP_005163857.1 mercuric reductase BAC0651 Protein 2e-86 44
merA YP_005163857.1 mercuric reductase BAC0652 Protein 4e-69 42