Gene Information

Name : thcA (CD31A_2130)
Accession : YP_005158824.1
Strain : Corynebacterium diphtheriae 31A
Genome accession: NC_016799
Putative virulence/resistance : Virulence
Product : aldehyde dehydrogenase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 2201315 - 2202835 bp
Length : 1521 bp
Strand : -
Note : NAD-dependent aldehyde dehydrogenases

DNA sequence :
ATGACTATTTATGCATATCCAGGAACGCCAGGTGCTGTAGCCAACTACAAGAAGCGCTACGACAACTACATCGGCGGCCA
ATGGGTTCCGCCGGTAGGTGGCGAATACTTGGACAACATCACCCCAGTCACCGGTGAAGTGTTCTGTCGAGTGGCACGAG
GAACCGCTGCCGACGTGGAAAAAGCCTTGGATGCAGCGCATGATGCAGCAAAAACATGGGGTCATAGCTCGCCGGCTGAG
CGCGCACTCATTCTGCACCGCATTGCCGATCGCATGGAAGAACATCTCGAAGAAATCGCCGTTGCCGAAACATGGGATAA
CGGCAAGGCGGTACGTGAAACTCTCGCCGCCGATATTCCACTGGCCATCGACCACTTCCGCTACTTTGCCGGAGCAATCC
GTGCCCAAGAATCACGAACCTCACAGATCGACCACAACACGGTGGCCTACCACTTCCATGAGCCCATCGGTGTAGTCGGT
CAGATCATTCCGTGGAACTTCCCACTGCTCATGGCTGCATGGAAGATCGCCCCAGCTCTTGCTGCGGGTAACACGATTGT
GTTGAAGCCCGCGGAGCAAACTCCTGCGTCCATTCTGTTCTGGATCGACATTGTTGGCGATCTGCTTCCTAACGGTGTGC
TCAACATCGTCAACGGCCTCGGCGAGGAAGCTGGCGTGGCGTTATCCTCTTCCAACCGCATTGGCAAGATTGCCTTTACT
GGTTCCACGCAGGTGGGCAAGATTATCAACCGTGCTGCCGCCGACAAGATCATCCCCGTCACCTTGGAGCTAGGCGGTAA
GTCGCCGTCGATCTTCTTCGCGGACATCATGGATTACGACGACCCCTTCCGCGAGAAGTGCATTGAGGGCCTTGCCATGT
TCGCGCTCAATCAGGGTGAGGTATGTACCTGCCCGTCGCGTGCGTTGGTGCATGAGTCCATCGCGGACGAGTTCCTTGAG
CTGGGTGTCCAACGTGTGAAGAACATCAAGCTCGGCAACCCGCTGGACACGGAAACCATGATGGGTGCCCAGGCTTCCAT
GGAACAAATGGATAAGATCAGTGGCTACCTCGATATTGGCCCGAAGGAGGGCGCTGAGGTGCTCACCGGTGGTCACGTGA
ACAAGATCGACGGTTTGGAAAATGGCTACTATATCGAGCCCACGGTGTTTAAGGGCACGAATGACATGACCATTTTCCGT
GAGGAAATCTTCGGCCCAGTGCTTTCGGTTGCTACCTTCAAGGATTTTGATGAGGCAATCCGCATTGCTAATGACACCAA
CTATGGCCTGGGTGCTGGTGTGTGGACTCGCCATCAGAACACTGCGTATCGTGCCGGACGCGCCATCCAAGCTGGTCGCG
TGTGGGTGAATCAATATCACAATTACCCAGCGCACGCAGCATTCGGAGGCTATAAGGAGTCCGGAATTGGGCGTGAGAAT
CACCTCATGATGTTGGATCACTATCAGCAGACAAAGAACCTTCTTGTCTCGTATGATGAGAATCCAACCGGCTTATTTTA
A

Protein sequence :
MTIYAYPGTPGAVANYKKRYDNYIGGQWVPPVGGEYLDNITPVTGEVFCRVARGTAADVEKALDAAHDAAKTWGHSSPAE
RALILHRIADRMEEHLEEIAVAETWDNGKAVRETLAADIPLAIDHFRYFAGAIRAQESRTSQIDHNTVAYHFHEPIGVVG
QIIPWNFPLLMAAWKIAPALAAGNTIVLKPAEQTPASILFWIDIVGDLLPNGVLNIVNGLGEEAGVALSSSNRIGKIAFT
GSTQVGKIINRAAADKIIPVTLELGGKSPSIFFADIMDYDDPFREKCIEGLAMFALNQGEVCTCPSRALVHESIADEFLE
LGVQRVKNIKLGNPLDTETMMGAQASMEQMDKISGYLDIGPKEGAEVLTGGHVNKIDGLENGYYIEPTVFKGTNDMTIFR
EEIFGPVLSVATFKDFDEAIRIANDTNYGLGAGVWTRHQNTAYRAGRAIQAGRVWVNQYHNYPAHAAFGGYKESGIGREN
HLMMLDHYQQTKNLLVSYDENPTGLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
VC0819 NP_230467.2 aldehyde dehydrogenase Not tested VPI-1 Protein 2e-147 63
aldA AAC12273.1 aldehyde dehydrogenase Virulence VPI Protein 7e-156 62
aldA AAK20747.1 aldehyde dehydrogenase Virulence VPI Protein 7e-156 62
aldA AAK20776.1 aldehyde dehydrogenase Virulence VPI Protein 7e-156 62
aldA-1 YP_001216300.1 aldehyde dehydrogenase Not tested VPI-1 Protein 2e-155 62

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
thcA YP_005158824.1 aldehyde dehydrogenase VFG0082 Protein 9e-148 63