Gene Information

Name : cadA (SMA_0310)
Accession : YP_005094021.1
Strain : Streptococcus macedonicus ACA-DC 198
Genome accession: NC_016749
Putative virulence/resistance : Resistance
Product : Cadmium-transporting ATPase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 318782 - 320899 bp
Length : 2118 bp
Strand : +
Note : -

DNA sequence :
ATGAGTGAGAAAATGACCGAAAAAACCTATCGAATAGAAGGATTAAGCTGTACAAATTGTGCAGGTAAATTTGAAAAAAA
TGTAAAGCAGTTGCCAGGAGTTACGAGTGCAACAGTAAACTTTGGTGCAAGTAAGATTTCAGTAGAAGGCCAAACAACAA
TTGAAGAACTCGAAGAAGCGGGAGCCTTCGAAAATCTTATCATTCGTGATGATCAAGAAAATGATGAACAAGTTAGATCA
AAAGAGTCTTTTATTAAACGGAATATCGCTTTAATCATCTCTCTTGGTTTTATACTTGTTGCTGTGATTTCCCAACTATC
ATTGGGCGAAGATCATTTATTAACGAAAGCTCTTTATATATTGGCAATAATAATTGGTGGATTTGATTTATTTAAAGAAG
GGTTCTCTGATTTGATCAAATTGGACTTCTCCATGGAATCTTTAATGACTATTGCAATTATTGGGGCCGCATTTATTGGA
GAATGGGCCGAAGGTTCTATTGTAGTAATACTATTTGCTATTAGCGAAGCTTTGGAACGATTTTCAATGGATAAAGCAAG
ACAGTCGATTCGTTCTCTTATGGATATAGCTCCCAAAGAAGCTCTTATCAGGAGAAACAATGTAGAGCAATTAGTCAGTG
TCGATAAAATCGATATCGACGATATTATGATCATTAAACCCGGACAAAAAATAGCCATGGATGGGCTTGTTATCAACGGT
CATTCTTCAGTAAATCAAGCAGCAATAACAGGAGAATCGGTTCCTGTTGAAAAACAGTTAGATGATGAAGTGTTTGCAGG
AACACTAAATGAAGAAGGTGTTCTTGAAGTCAAAGTAACAAAAAAAGTAACGGATACAACGATTGCCAAAATCATTCACT
TAGTTGAAGAAGCGCAAGGAGAACGAGCTCCTGCACAAGCCTTTGTAGATAAATTTGCAAAATACTATACGCCATTCATA
ATTATTATGGCCCTTTTGATAGTGGTTGTTCCTCCGCTATTCTTTGGTGGTGACTGGAATAAATGGCTTTACCAAGGGTT
ATCCATTTTAGTTGTCGGATGTCCTTGTTCATTAGTGATCTCAACACCTGTTTCAATTGTTTCGGCTATTGGTAATGCAG
CAAAAAATGGTGTTTTAGTAAAAGGCGGAGTCTATCTGGAAGAAATTGGTCATTTGAGAGCAATTGCTTTCGATAAGACT
GGAACCTTAACAAAAGGAAAGCCTGTCGTAACGGATTTCATTGCAACCAGTTCTGAAACTGATATAAATTATCTATCGAT
TATTTCATCGTTGGAATCTCTTTCTCAACACCCATTAGCTTCTGCTATTTTAAACGAAGCGGATAAAACTAATGTGGATT
ACAAGTCAATACAAATAGAGGATTTCCAATCTATCACAGGTAAAGGACTTACAGGTATACATCAAAACATACGTTACTAT
ATTGGAAGCCCTAAACTGTTTTCTGCATCAGTAATCGAAGAAACAGCGGTCAAAGTACAATACAGACAATTTCAAGAACA
AGGGAAAACCGCCATGTATTTCGGTACTGACGAACAAATTTTAGGAGTAATTGCTGTCGCGGATGAAGTAAGAGATTCAA
GTGCTGCCGTTATTTCTGAACTCCACAAGTTGTCAATTGAACACACTATTATGCTTACTGGTGATAATACTAAAACCGCT
GAATCTATTGGTAAGCAATTAGGTGTGACTGAAATAAAAGGAGATCTAATGCCTCAAGAAAAATTAGATTCGATTAAAGC
GTTGCGGACAACTTATAATAAAGTAGCAATGGTGGGCGACGGCATTAATGATGCACCAGCATTAGCTGCATCGACGGTTG
GTATTGCAATGGGCGGTGCAGGAACAGATACGGCTCTCGAAACTGCTGATGTTGCTCTAATGGGCGACGATTTACAAAAA
TTACCATTCATTGTTAGACTTAGCCGTCAAACTCTAAAAGTAATTAAGCAAAATATCACCTTCTCATTAGGTATAAAACT
ATTAGCTCTACTACTAGTCATACCAGGTTGGCTAACACTATGGATTGCTATTGTAGCAGATATGGGAGCAACGCTTTTAG
TAACATTAAACGGATTACGATTGATGAAAGTTAAATAA

Protein sequence :
MSEKMTEKTYRIEGLSCTNCAGKFEKNVKQLPGVTSATVNFGASKISVEGQTTIEELEEAGAFENLIIRDDQENDEQVRS
KESFIKRNIALIISLGFILVAVISQLSLGEDHLLTKALYILAIIIGGFDLFKEGFSDLIKLDFSMESLMTIAIIGAAFIG
EWAEGSIVVILFAISEALERFSMDKARQSIRSLMDIAPKEALIRRNNVEQLVSVDKIDIDDIMIIKPGQKIAMDGLVING
HSSVNQAAITGESVPVEKQLDDEVFAGTLNEEGVLEVKVTKKVTDTTIAKIIHLVEEAQGERAPAQAFVDKFAKYYTPFI
IIMALLIVVVPPLFFGGDWNKWLYQGLSILVVGCPCSLVISTPVSIVSAIGNAAKNGVLVKGGVYLEEIGHLRAIAFDKT
GTLTKGKPVVTDFIATSSETDINYLSIISSLESLSQHPLASAILNEADKTNVDYKSIQIEDFQSITGKGLTGIHQNIRYY
IGSPKLFSASVIEETAVKVQYRQFQEQGKTAMYFGTDEQILGVIAVADEVRDSSAAVISELHKLSIEHTIMLTGDNTKTA
ESIGKQLGVTEIKGDLMPQEKLDSIKALRTTYNKVAMVGDGINDAPALAASTVGIAMGGAGTDTALETADVALMGDDLQK
LPFIVRLSRQTLKVIKQNITFSLGIKLLALLLVIPGWLTLWIAIVADMGATLLVTLNGLRLMKVK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 0.0 65
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 0.0 65
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 0.0 65

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cadA YP_005094021.1 Cadmium-transporting ATPase BAC0298 Protein 2e-112 47
cadA YP_005094021.1 Cadmium-transporting ATPase BAC0092 Protein 1e-97 42