Gene Information

Name : KOX_24285 (KOX_24285)
Accession : YP_005020811.1
Strain : Klebsiella oxytoca KCTC 1686
Genome accession: NC_016612
Putative virulence/resistance : Resistance
Product : RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family protein
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 5231065 - 5234127 bp
Length : 3063 bp
Strand : +
Note : COG0841 Cation/multidrug efflux pump

DNA sequence :
ATGGATATTTCCCGCCAGTTTATTAACAACCCGGTCCGCGTCTGGCTGACCATTTTGCTGCTGGGCATCGGCGGGATCTT
CGCTCTGCTGAATATTGGCCGCCTGGAAGATCCGGCGTTTACCATCAAAACCGCGGTGGTGGTCACCCACTATCCCGGCG
CGTCGGCGCAGCAGGTGGAAGAAGAAGTCACCCTGCCGCTGGAAAACGCGCTGCAGCAGCTGCCGTATCTCGACAACGTC
AGCTCAATTTCCTCCAACGGCCTGTCGCAAATTACCGTCAATATCGCCTCGCGCTACCACTCCCGCGAGCTGCCGCAAAT
CTGGGATGAACTGCGCCGCCGGGTGGGCGACGCCGCCCGCCAGTTCCCTCCCGGCGTCGCCGCTCCGTTTGTGAACGACG
ATTTTGGCGATGTCTTTGGCTTCTTCTTTGCCCTCTCCGGCGAGAGCTTTACCAACCCTGAGCTGGTTCGCTATGCCGAG
CAGCTGCGTCGCGAACTGGTGCTGGTCCCCGGCGTCGGCAAAGTCGCCATCGGCGGGGCGATCCCCCAGCAGATCAACAT
CGATATCTCGCTGGCGAAAATGGCCGCCCGCGGAATCACGCTCAACCAGCTGGCGGCGATACTGAGCAGGTTGAACGTGG
TGTCTAACGCCGGTGAGATTAAATCCGGCAGCGAATCGATTCGCCTGCATCCCACGGGCGAGTTTGCCAACCTCGACGAG
CTTGGCGACCTGTTAATCAGCCCGCACGGCTCGGCAACGGCGACGCGGCTGCGCGATATTGCCACGCTCTCGCGCGGGCT
GAGCGAATCGCCTTCCAGCATTTACCACGCCAACGGTCGACAGGCGGTCACTATGGGGGTGTCGTTTATACCCGGGGTTA
ACGTGATTGACGTTGGCCGCGCGCTGGAAAGCAAGCTGGAGCAGATGTCGGCGGAAAAACCGGCCGGGATCAACATTGAC
CTGTTCTACGATCAGGCGGCGGAAGTCGCCCATTCGGTCAACGGCTTTATCACCAACTTCCTGATGGCGCTGGCGATTGT
GGTTGGCGTGCTGCTGATCTTTATGGGCGTACGCAGCGGCATTATTATCGCCCTGTCGCTGGCGCTCAACGTGCTCGGTA
CGCTGTTGATCATGTACCTGTGGGGTATCGAGCTGCAGCGTATCTCGCTGGGGGCGTTGATTATCGCCCTGAGCATGCTG
GTCGATAACGCTATCGTCATCGTCGAAGGCGTGCTGATCGCCCGCCAGCAGGGGTCAACGCTGCTCATGGCGATTAACTA
CGCGATCCGCCGTTCGGCGCTGCCGCTGCTGGGGGCCACGGTGATTGCCATTCTCGCCTTTGCGCCGATTGGCCTGTCGC
AGGACTCGACCGGGGAATACTGTAAATCGCTGTTCCAGGTGCTGCTGATTTCGCTCATGCTGAGCTGGTTCTCGGCGCTG
ACCATTACCCCGGTGCTGATTAAATGGTGGCTGTTTAAAAATCAATCGCAGCCGGTGGCGCAGGCCGACGCCAATCCGTA
CGGCGGGCGCTTTTACCGTCTGTACCAGCAGGCTCTGCGTGCTCTTCTGCTGCGCAAAACCATCACGCTGACCGTCATGG
CGGCGCTGCTGGCCGCCGCTATCTGGGGATTCGGCTCGGTGCGGCAAAACTTTTTCCCCTCTTCAAACACGCCCATTTTC
TTTGTCGATCTCTGGCTACCCTACGGTACCGATATCGCGACCACCGAAAAGATGACCAGCGATATTGAGACCACCATTAA
CGGCCAGCCGGGCGTGGTCACCACCGTGGCCACCGTCGGTCAGGGCAGCATGCGGTTTATCCTCACCTACAGCGGGCAAC
GGCAGTATAGCAACTATGCGCAGATCATGGTGCGCATGGACGACCAGCGCAGCATTGCCGCCCTGACGCAGCATGTGGAT
CGCTATATTGCGCGCAACTACCCGCAGGTGAACGCCAGCACGAAGCGCGTGATGTTCGGTCCCTCCGGCGACAGCGCCAT
CGAGGTGCGGATTAAAGGTCCGGACCCCGACCGTCTGCGCCTGCTCGCCAGCCAGGTTGGCGATATCCTCTCCGCGGACC
CGGCCACCGACGGCGTTCGCAACGACTGGCAAAACCGTAGCAAAGTTATTCGTCCGCAGTACTCCCCCGCGCTTGGGCGC
GAGCTGGGCGTTGATAAGCAGGATATTGATAACGCCCTGGAGATGAACTTCTCCGGCAGCCGCGTTGGATTGTACCGTGA
GGGGGCCGACCTGCTGCCGGTGATAGTCCGCCCGCCCGCCGCCGAGCGCCAGGACGCGAATCACCTGAATAACGTGCTGG
TCTGGAGCCAGAGCCGCCAGCAGTATATTCCGCTCAGTAACGTGGTCAGCGGCTTTCACCTTGAATGGGAAGATCCGCTG
ATTCTGCGCCGCGATCGCAGCCGGGTGCTGACGGTACAGACCGATCCCGACCCGCTCAGCCACCAGACGTCCGGGGATAT
CCTGTCCCGCGTGAAGCCGCAGATTGATGCGCTCGCTCTGCCGCACGGTTACAGCATTGAGTGGGGTGGCGATGCGGAGA
ACTCGAGCGAGGCGCAGCAGGGGCTGTTTACTACCCTGCCGCTGGGTTACCTGGTGATGTTTGTCATCACCGTCCTGATG
TTCAGTTCGCTGAAAAATGCGATCGCCATCTGGCTGACCGTGCCGCTGGCGCTGATTGGCGTTACGCCGGGCTTTTTAAT
TACCGGGATCCCTTTTGGATTTATGGCGTTAATCGGTCTGCTGAGCCTGAGCGGAATGCTGATCCGTAACGGCATCGTGC
TGGTAGAAGAGATTGAACAGCAGAAACAGGAAAAAGCGCAGCAGGAGGCGATTATTGATGCCGCCACTTCGCGTCTGCGC
CCTATCCTGCTGACGGCGTTTACCACCGTGCTCGGCCTGGCGCCTTTATTACTCGACGTTTTCTTCCAGAGCATGGCGGT
CGTTATCATGTTTGGTCTGGGTTTTGCTACTATTCTGACGCTGCTGGTTCTGCCGGTAATCTACGCCTGTTTCCACAATC
AGAATATGAAGCGACAACCATGA

Protein sequence :
MDISRQFINNPVRVWLTILLLGIGGIFALLNIGRLEDPAFTIKTAVVVTHYPGASAQQVEEEVTLPLENALQQLPYLDNV
SSISSNGLSQITVNIASRYHSRELPQIWDELRRRVGDAARQFPPGVAAPFVNDDFGDVFGFFFALSGESFTNPELVRYAE
QLRRELVLVPGVGKVAIGGAIPQQINIDISLAKMAARGITLNQLAAILSRLNVVSNAGEIKSGSESIRLHPTGEFANLDE
LGDLLISPHGSATATRLRDIATLSRGLSESPSSIYHANGRQAVTMGVSFIPGVNVIDVGRALESKLEQMSAEKPAGINID
LFYDQAAEVAHSVNGFITNFLMALAIVVGVLLIFMGVRSGIIIALSLALNVLGTLLIMYLWGIELQRISLGALIIALSML
VDNAIVIVEGVLIARQQGSTLLMAINYAIRRSALPLLGATVIAILAFAPIGLSQDSTGEYCKSLFQVLLISLMLSWFSAL
TITPVLIKWWLFKNQSQPVAQADANPYGGRFYRLYQQALRALLLRKTITLTVMAALLAAAIWGFGSVRQNFFPSSNTPIF
FVDLWLPYGTDIATTEKMTSDIETTINGQPGVVTTVATVGQGSMRFILTYSGQRQYSNYAQIMVRMDDQRSIAALTQHVD
RYIARNYPQVNASTKRVMFGPSGDSAIEVRIKGPDPDRLRLLASQVGDILSADPATDGVRNDWQNRSKVIRPQYSPALGR
ELGVDKQDIDNALEMNFSGSRVGLYREGADLLPVIVRPPAAERQDANHLNNVLVWSQSRQQYIPLSNVVSGFHLEWEDPL
ILRRDRSRVLTVQTDPDPLSHQTSGDILSRVKPQIDALALPHGYSIEWGGDAENSSEAQQGLFTTLPLGYLVMFVITVLM
FSSLKNAIAIWLTVPLALIGVTPGFLITGIPFGFMALIGLLSLSGMLIRNGIVLVEEIEQQKQEKAQQEAIIDAATSRLR
PILLTAFTTVLGLAPLLLDVFFQSMAVVIMFGLGFATILTLLVLPVIYACFHNQNMKRQP

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
VC0395_A1355 YP_001217299.1 AcrB/AcrD/AcrF family transporter Not tested VPI-2 Protein 4e-157 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
KOX_24285 YP_005020811.1 RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family protein BAC0519 Protein 0.0 50
KOX_24285 YP_005020811.1 RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family protein BAC0428 Protein 0.0 50
KOX_24285 YP_005020811.1 RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family protein BAC0526 Protein 0.0 47
KOX_24285 YP_005020811.1 RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family protein BAC0425 Protein 2e-157 41