Gene Information

Name : Sfla_5614 (Sfla_5614)
Accession : YP_004926526.1
Strain : Streptomyces flavogriseus ATCC 33331
Genome accession: NC_016114
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : -
Position : 6430067 - 6431788 bp
Length : 1722 bp
Strand : +
Note : TIGRFAM: urease, alpha subunit; KEGG: sgr:SGR_6297 urease subunit alpha; PFAM: amidohydrolase; Urease alpha-subunit domain-containing protein

DNA sequence :
ATGCCTGAGCTCAGCCGTCCCGTGTACGCAGACCTGTTCGGGCCCACCACCGGTGACCGCATCCGGCTCGCCGACACCGA
TCTGGTCGTCGAGATCGAGGAGGACCGGTCCGGCGGTCCCGGACTGGCCGGGGACGAGGCCGTCTTCGGCGGAGGCAAGG
TGATCCGCGAGTCGATGGGCCAGGCGCGGACCACCCGTGCCGAGGGCGCCCCCGACACCGTGATCACCGGTGCCGTCATC
ATCGACCACTGGGGCGTCGTCAAGGCCGACATCGGCATCCGCGACGGCCGGATCACCGGGATCGGCAAGGCCGGGAATCC
CGACACGATGGACGGGGTCCACCCCGAACTGGTCATCGGGCCCGAGACCGAGATCATCGTGGGCAACGGCAAGTTCGTCA
CCGCCGGCGCCATCGACGCGCACGTCCACTTCATCTCGCCGACCCTCGTCGACCAGGCCCTGTCCTCCGGGATCACCACA
CTGGTCGGCGGGGGTACGGGCCCGGCCGAGGGGACCAAGGCCACCACGATCACCCCGGGGCCCTGGCATCTGGCCCGGAT
GTTCGAGGCGCTGGACGGCTACCCCGTCAACATCGGACTGCTCGGCAAGGGCAACACGATGTCGCGCGAGGCCATGCACT
CCCAACTGCGCGCCGGGGCACTCGGGTTCAAGATCCATGAGGACTGGGGAGCGACCCCCGCCGTGATCGACGCCTGCCTG
GGCGTCTGCGAGGAGACCGGAGCCCAGCTCGCCATCCACACGGACACGCTCAACGAGGCCGGGTTCGTCGCCGACACGCT
GGCCGCCATCGCCGGGCGCTCGATCCACGCGTACCACACCGAAGGCGCGGGAGGCGGCCACGCCCCCGACATCATCAGCG
TGGTGTCGGAGCCCTACGTCCTGCCCAGCTCCACCAACCCGACCCGCCCGCACACCGTCAACACGATCGAGGAACACCTC
GACATGCTGATGGTCTGCCACCACCTCAACCCCACCGTCCCGGAGGACCTCGCCTTCGCCGAGTCACGCATCCGCCCCTC
GACCATCGCGGCCGAGGACATCCTGCACGACCTCGGAGCCATCTCGATCATCTCCTCGGACTCCCAGGCGATGGGCCGCA
TCGGCGAGGTGATCCTGCGCACCTGGCAGACCGCCCACGTGATGAAGCGGCGGCGCGGCGCGCTGCCGGGCGACGGGGCC
GCCGACAACCACCGCGCACGTCGCTATGTCGCCAAATACACCATCAACCCGGCGGTGGCCCAAGGGCTGGACCGTGAGAT
CGGCTCCGTGGAACCGGGCAAGCTCGCCGACCTCGTCCTGTGGGACCCGGCGTTCTTCGGCGTCAAGCCGCAGACAGTGA
TCAAGGGGGGCCAGATCGCCTACGCGCAGATGGGCGACGCCAACGCCTCGATCCCCACGCCGCAGCCGGTCATGCCCCGT
CCGATGTTCGGGGCCGTGGGACGGGCCCCCGCCGCCAACTCCTTCAACTTCGTCTCCTCCGCGGCCGTCGAGGCCGGGTT
GCCGGAACACCTCGGACTCGGCAAGAGGTTCGTGCCGATCAGCAGCACCCGTGGCGTCACCAAGGCGGACATGCGCGAGA
ACGACGCCCTGCCCCGGGTCGAGGTCGACCCCGACAGCTTCGCCGTCACCATCGACGGTGATCCTGTCGTCCCAGCCCCC
GCCGCGGAACTCCCGATGGCCCAGCGCTACTTCCTCTTCTGA

Protein sequence :
MPELSRPVYADLFGPTTGDRIRLADTDLVVEIEEDRSGGPGLAGDEAVFGGGKVIRESMGQARTTRAEGAPDTVITGAVI
IDHWGVVKADIGIRDGRITGIGKAGNPDTMDGVHPELVIGPETEIIVGNGKFVTAGAIDAHVHFISPTLVDQALSSGITT
LVGGGTGPAEGTKATTITPGPWHLARMFEALDGYPVNIGLLGKGNTMSREAMHSQLRAGALGFKIHEDWGATPAVIDACL
GVCEETGAQLAIHTDTLNEAGFVADTLAAIAGRSIHAYHTEGAGGGHAPDIISVVSEPYVLPSSTNPTRPHTVNTIEEHL
DMLMVCHHLNPTVPEDLAFAESRIRPSTIAAEDILHDLGAISIISSDSQAMGRIGEVILRTWQTAHVMKRRRGALPGDGA
ADNHRARRYVAKYTINPAVAQGLDREIGSVEPGKLADLVLWDPAFFGVKPQTVIKGGQIAYAQMGDANASIPTPQPVMPR
PMFGAVGRAPAANSFNFVSSAAVEAGLPEHLGLGKRFVPISSTRGVTKADMRENDALPRVEVDPDSFAVTIDGDPVVPAP
AAELPMAQRYFLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 1e-159 61
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 1e-159 61
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-148 59
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 6e-149 59
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 6e-149 59
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 6e-149 59

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Sfla_5614 YP_004926526.1 urease subunit alpha VFG0270 Protein 7e-141 56