Gene Information

Name : Sfla_4857 (Sfla_4857)
Accession : YP_004925775.1
Strain : Streptomyces flavogriseus ATCC 33331
Genome accession: NC_016114
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : -
Position : 5598782 - 5600506 bp
Length : 1725 bp
Strand : +
Note : TIGRFAM: urease, alpha subunit; KEGG: sgr:SGR_846 urease subunit alpha; PFAM: amidohydrolase; Urease alpha-subunit domain-containing protein

DNA sequence :
ATGCCCATCCTGCCGCGCAAGCAGTACACCGACATGTTCGGTCCGACGGTCGGCGACCGTTTCCACCTCGGCGACACCAA
CCTCGTCGTAGAGGTCGAGAAGGACTACAGCGAGGGGCAGTACGGGGACGAGGTCCTCTACGGCGGCGGCAAGACCATGC
GCGACGGCATGGCCTCCGACCCTCAGGCCACCAGCGCCCAGGGCGCCCTCGACACCGTCATCACCAATGTCGTGGTCATC
GACCCGGTCGTCGGCGTCGTGAAGTGCGACATCGGGATCAAGGACGGCTTCATCGTCGACATCGGCAAGTCCGGCAATCC
GCAGACCCAGGACAAGGTCCACCCCGGCCTGATCATCGGCCCCGGCACGGAGGCCATCGCAGGCGAGCACCTCATCGCCA
CGGCGGGCGCCATCGACACCCACGTCCACCTGATCGCCCCACAGCAGGCCGAGCAGGCACTCACCAACGGCATCACCACG
CTCATCGGCGGCGGCACCGGCCCGACCGACGGCTCCAACGGCACCACCTGCACTCCCGGGCCGTACAACATCGGCAAGCT
GCTCCAGGCCGCCGAGAGCATCCCGGTCAACATCGGCATCATGGGCAAGGGCAACGGCAGCCTCCCCGAGGCGCTGAACG
AGCAGGTCGTCGCCGGAGCCTGCGCCCTGAAGGTCCACGAGGACTGGGGCGCCACCCCCGCCGTGATCGACAACGCCCTG
AACGTCGCCGACGAGCACGACGTCCAGGTCGCCATCCACACGGACAGCCTCAACGAGGGCGGGTTCTTCGAGGACACCCG
CTCGGCGATCGACGGACGGACCATCCACACCTTCCACAGCGAGGGCGCGGGCGGTGGTCACGCCCCCGACATCATGCGGG
TGGCCGGGGAGCCCAACGTTCTGCCGTCCTCGACCAACCCGACGCTGCCGTACACCAAGAACTCCGTGGACGAGCTGCTG
GACATGGTGATGGTCTGTCACCACCTCAGCCACGACATCCCCGAGGACGTCTCCTTCGCCGACAGCCGCGTCCGGGCCGA
GACCATCGCCGCCGAGACGGTACTGCACGACCTCGGAGTGATCAGCATGTTCTCCTCCGACTCGCAGGCCATGGGCCGGG
TCGGTGAATCGGTCACCCGTGCCTTCCAGACCGCCCACCACTGCAAGGACAAGCTCGGTCCGCTGGAAGGCGACTCCGAA
CGCAACGACAACCAGCGGGTCCTGCGCTACCTCGCGAAGGTCACCATCAACCCGGCGATCGCCACCGGCATCTCGGACCA
CGTGGGCTCCATCGAGAAGGGCAAGATCGCGGACATCGTGCTCTGGCCCATCCACTCCTTCGGCGCCAAGCCGAAGATGG
TGATCAAGGGCGGCATCGTCTCCTGGGCGCAGATGGGCGATCCCAACGCCTCGCTGCCGACCCCGCAGCCCGTGATCTAC
CGCCCGATGTTCGGCCAGTTCGGCAGGGCCCAGCAGTCCACGCACGTCACCTTCATGTCACAGGCGGGCATCGCGGCCGG
AGTCCCCGCCGAGCTCGGCCTGGAACGCAAGGTCCTGCCCGTGCTGCGCACCCGGACCATCGGCAAGCACAACATGATCC
GCAACGACGCGCTGCCGCACATCAAGGTCGACCCGGAGACGTTCAAGGTCACCCTCAACGGCAAGGTCGCGACCATCGAC
CCGGCCGAGAAGCTCCCCCTCAACCACCTGTTCTTCCTGGTCTAG

Protein sequence :
MPILPRKQYTDMFGPTVGDRFHLGDTNLVVEVEKDYSEGQYGDEVLYGGGKTMRDGMASDPQATSAQGALDTVITNVVVI
DPVVGVVKCDIGIKDGFIVDIGKSGNPQTQDKVHPGLIIGPGTEAIAGEHLIATAGAIDTHVHLIAPQQAEQALTNGITT
LIGGGTGPTDGSNGTTCTPGPYNIGKLLQAAESIPVNIGIMGKGNGSLPEALNEQVVAGACALKVHEDWGATPAVIDNAL
NVADEHDVQVAIHTDSLNEGGFFEDTRSAIDGRTIHTFHSEGAGGGHAPDIMRVAGEPNVLPSSTNPTLPYTKNSVDELL
DMVMVCHHLSHDIPEDVSFADSRVRAETIAAETVLHDLGVISMFSSDSQAMGRVGESVTRAFQTAHHCKDKLGPLEGDSE
RNDNQRVLRYLAKVTINPAIATGISDHVGSIEKGKIADIVLWPIHSFGAKPKMVIKGGIVSWAQMGDPNASLPTPQPVIY
RPMFGQFGRAQQSTHVTFMSQAGIAAGVPAELGLERKVLPVLRTRTIGKHNMIRNDALPHIKVDPETFKVTLNGKVATID
PAEKLPLNHLFFLV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 6e-137 58
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 6e-137 58
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 5e-136 56
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 7e-136 56
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 7e-136 56
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 7e-136 56

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Sfla_4857 YP_004925775.1 urease subunit alpha VFG0270 Protein 2e-135 56