Gene Information

Name : hsdM (TEH_19020)
Accession : YP_004887393.1
Strain : Tetragenococcus halophilus NBRC 12172
Genome accession: NC_016052
Putative virulence/resistance : Unknown
Product : type I restriction-modification system DNA methylase
Function : -
COG functional category : V : Defense mechanisms
COG ID : COG0286
EC number : 2.1.1.-
Position : 1906681 - 1908183 bp
Length : 1503 bp
Strand : -
Note : protein synonym:type I restriction enzyme M protein

DNA sequence :
ATGACACAAAAATCAAATGCAAACTTAGGTTTTGAAAAAGAACTATGGGCTGCAGCAGATGCGATGCGTAGTCATGTTTC
ATCTTCAGATTATCGCAAGGTTGTTGTAGGATTAATATTTTTAAAATATGTATCCGACGCTTTTGAGTATCGCTATCAGG
AACTTCTTGAAGAAGGGTATGGTGATGAGGAAGATCGTGATGCTTATATAGAAAAAAATATTTTCTTTGTTCCAGAAGCT
GCTCGTTGGAAAAAAATTGCATCAAGTGCTCACTCACCAGAAATTGGTATTGTTCTGGATGAGGCAATGCGAGCAGTTGA
AAAAGAAAATAACTCGTTAAAGGGTGTATTACCAATCATTTATGCAAGTCCAGATTTGGACAAGCGGGTATTAGGTAATG
TCGTTGATATTTTTACTAATATTAATATGCATGATCAGAGTGAAGAAAAGGATCTGTTAGGTCGTACTTATGAATACTTT
ATTGAACAATTTGCTGCTCAAGAAGGCAAAGGCGGGGGAGAATTTTATACACCCTCAAGTATAGTAAAAACGATTGTGGA
AGTGCTAAAGCCTTATAAAGGAAGAGTTTATGACCCCGCTTGTGGCTCGGGTGGTATGTTTGTGCAATCAGCTAAATTCG
TAAAACAACATAGTGGTAATATTAATAATTTGTCTATTTATGGTGAAGAGTCGAACTCTGATACTTGGAAAATGGCTAAG
ATGAATATGGCTATTCGTGGTTTAGAAGCTGATTTTGGTCCTCATCAAGCAGATACATTTTTAAATGATATACATCCAAC
TTTAAAAGCTGACTATATTATGGCGAATCCACCATTTAATGTTTCTGATTGGTGGGATGAATCTTTACAAGATGATGTGC
GGTGGAAATATGGTACGCCACCTAAAAGTAATGCTAACTATGCATGGATGCAGCATATGATCTCTCATTTAGCACCTAAC
GGAAAAATTGGCTTAGTCTTAGCTAATGGCTCTCTATCAACGTTAAATAGTGGCGAGGGGGAGATTCGTAAACGAATTAT
TGATGATGATTTAGTTGAAGGAATTGTAGCATTACCATCTAATCTTTTTTATAGCGTGACTATTCCAGCTTGTATATGGT
TTATTTCTCGTAATAAAAAACAAAATGGCAAAACAGTATTCATAGATGCACGTAAAATGGGAACATTAGTTGATCGAAAG
CACCGAGATTTTAGTAACGATGAGATAAAGAAAATTGCAGATACGTTTGAATCATTTCAGAATGGTGAACTTGAAGATGC
AAAAGGTTTTTGTGCAGTGGTAGAAACAGCGGATATAGCAAAACAAGATTATATCTTAACACCTGGTCGTTATGTTGGAA
TTGAGGAACAAGAAGAGGATGCTGAACCATTTGATGAAAAAATGGAGCGTTTGACAAGTGAACTATCTGAAATGTTTGAT
AAATCGCACGAACTTGAAGACAAGATTCGTAAACGGTTGGAGGAGATTGGTTTTGGATTATAA

Protein sequence :
MTQKSNANLGFEKELWAAADAMRSHVSSSDYRKVVVGLIFLKYVSDAFEYRYQELLEEGYGDEEDRDAYIEKNIFFVPEA
ARWKKIASSAHSPEIGIVLDEAMRAVEKENNSLKGVLPIIYASPDLDKRVLGNVVDIFTNINMHDQSEEKDLLGRTYEYF
IEQFAAQEGKGGGEFYTPSSIVKTIVEVLKPYKGRVYDPACGSGGMFVQSAKFVKQHSGNINNLSIYGEESNSDTWKMAK
MNMAIRGLEADFGPHQADTFLNDIHPTLKADYIMANPPFNVSDWWDESLQDDVRWKYGTPPKSNANYAWMQHMISHLAPN
GKIGLVLANGSLSTLNSGEGEIRKRIIDDDLVEGIVALPSNLFYSVTIPACIWFISRNKKQNGKTVFIDARKMGTLVDRK
HRDFSNDEIKKIADTFESFQNGELEDAKGFCAVVETADIAKQDYILTPGRYVGIEEQEEDAEPFDEKMERLTSELSEMFD
KSHELEDKIRKRLEEIGFGL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hsdM YP_251979.1 type I restriction-modification system DNA methylase Not tested SCCmec Protein 3e-136 58
hsdM BAH57701.1 type I restriction-modification system DNA methylase Not tested Type-VII SCCmec Protein 2e-136 58
hsdM BAD24842.1 HsdM protein Not tested Type-V SCCmec Protein 2e-134 57
api49 CAF28523.1 putative HsdM-like N-methyl transferase Not tested YAPI Protein 8e-110 46