Gene Information

Name : RHOM_03585 (RHOM_03585)
Accession : YP_004837771.1
Strain : Roseburia hominis A2-183
Genome accession: NC_015977
Putative virulence/resistance : Virulence
Product : heat shock protein ClpB-like protein
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 780336 - 782921 bp
Length : 2586 bp
Strand : +
Note : COG0542 ATPases with chaperone activity, ATP-binding subunit

DNA sequence :
ATGAACATTCAGAAATTTACACAAAAGTCAGTGGAAGCCATTAACGATTGCGAGAAGCTTGCCTATGAATATGGAAATCA
GGAGATCGAGCAGGAGCATCTTCTGGTTGCACTCATGCGGCAGGAGGATGGACTGATTCCGAAGCTGATTGAGAAGATGG
AGATTCAGAAGGAGCACTTCATGGATAACGCCGAGCGGCATCTGGCAGCGCGTGTCAAGGTGTCTGGCGGTCAGGTCTAT
GTCGGACAGGATTTAAATAAGGTGCTCATTCATGCCGAGGATGAGGCGAAGCAGATGGGGGACGAGTATGTTTCTGTCGA
GCATCTGTTCCTGGCGCTGATCAAGTATCCGAATAAGGCATTGAAGGAGATCTTTAAGGAGTACGGCATTACCAGAGAAC
GGTTTTTGCAGGCGCTCTCGACAGTCCGCGGCAATCAGCGCGTGACATCGGACAATCCGGAAGCAACCTACGACACGCTG
GAGAAGTACGGGTATGATATGGTAGCCCGTGCGAGAGACCAGAAGCTGGATCCGGTCATCGGACGTGATGATGAGATCCG
GAATGTCGTGCGGATTCTGTCCCGTAAGACGAAAAACAACCCGGTGCTGATCGGTGAGCCGGGTGTCGGCAAGACGGCTG
TTGTCGAGGGGCTTGCCCAGCGAATTGTAAAAGGCGATGTGCCGGAGGGCTTAAAGGACAAGAAATTGTTTGCACTGGAT
ATGGGTGCGTTAATCGCAGGTGCAAAATACCGCGGTGAATTCGAGGAGCGGTTAAAGGCAGTGCTTGATGAGGTGAAAAG
TTCCGAGGGACAGATTATCCTGTTCATTGATGAGCTTCACACGATCGTGGGTGCGGGCAAGACGGATGGTGCGATGGATG
CCGGACAGCTGTTAAAGCCGATGCTTGCGCGTGGTGAACTGCATTGTATCGGTGCGACGACCCTGGATGAGTACCGCGAA
TACATTGAAAAAGATGCGGCGCTCGAGCGTCGTTTCCAGCCGGTAATGGTGGATGAGCCGACGGTCGAGGATACCATCTC
CATTTTGCGTGGATTGAAGGAGCGCTACGAGGTTTTCCATGGAGTTAAGATTACAGATTCTGCGCTGGTATCGGCAGCAG
TGCTCTCCAACCGTTATATTTCGGATCGTTTTCTTCCAGATAAAGCGATCGATCTGGTCGATGAGGCGTGCGCGCTGATC
AAGACCGAGCTGGATTCCATGCCGACGGAACTGGACGAGTTGAACCGCCGTGTCATGCAGATGGAGATTGAGGAGACAGC
GCTGAAAAAGGAGACCGACCGTCTGAGCCAGGAGCGTCTGGCAAATCTGCAGAAAGAACTGGCAGAGCTGCGCGATGAAT
TCAACACGAAGAAAGCGCAGTGGGAGAATGAGAAAAAGTCGGTAGAAAAAGTACAGAAGCTGCGTGAGGAGATCGAAGCG
GTCAAGAATGAGATCAAGATGGCACAGCAGAAGTACGATCTGGAGAAGGCAGCCGAATTGCAGTACGGCAAGCTGCCACA
GCTACAGAAGCAGTTGGAGATCGAGGAGGAAGCCGTGAAGAAACGCGACCTTTCCCTGGTGCATGAAAACGTCAGTGAGG
AAGAGATTGCGCGGATCATCTCCAGATGGACAGGAATTCCGGTGGCAAAGCTGACGGAGAGCGAGCGTAACAAGACGCTG
CATCTCGACGAGGAACTGCACAAACGTGTCATCGGCCAGGATGAGGGCGTCACGAAAGTGACGGAAGCAATCATCCGTTC
CAAAGCAGGTATCAAAGACCCGAGTAAGCCGATCGGATCATTCCTGTTCTTAGGACCGACCGGTGTTGGTAAGACAGAGC
TTGCAAAGGCGCTTGCAGCAAGTCTCTTCGATGATGAGTCGAATATGGTGCGTCTTGATATGAGTGAGTATATGGAGAAA
TATTCCGTCTCCCGTCTGATCGGAGCGCCTCCAGGATATGTCGGATACGATGAGGGTGGACAGCTGACCGAGGCAGTGCG
CAGAAAGCCGTATTCGGTGGTATTGTTTGATGAGGTGGAGAAGGCACATCCGGATGTGTTCAACGTTCTGTTGCAGGTAC
TGGACGATGGACGAATCACAGATTCACAGGGACGTACCGTCGATTTTAAGAATACAATCATCATCATGACATCGAACCTT
GGATCAGCACATCTGCTTGAGGGCATCGATGCAAACGGGGATATCAATCCGGAGTGCGAAGCGGCAGTTATGGACGAACT
GCGCGGACATTTCCGTCCGGAGTTTTTGAACCGTCTGGATGAGATTATTATGTTTAAGCCGCTGACGAAGGACAACATCG
GTAACATCATCAACCTTCTGGTTGCAGATCTCAACAAACGTCTGGCAGACCGTGAGATCACGGTGGAACTGACCGATGCG
GCAAAGCAGTATATCGTGGAAAACGGATATGATCCGATCTACGGTGCAAGACCGTTAAAGCGGTTCTTACAGAAGCATGT
GGAGACACTTTCCGCAAAGCTGATTCTTGCGGATAAAGTCAGGGAGGGAGATACGATTCTGATTGATGTCTCCGGAAATG
AACTGACGGCAGCAGTGAAAGCGTGA

Protein sequence :
MNIQKFTQKSVEAINDCEKLAYEYGNQEIEQEHLLVALMRQEDGLIPKLIEKMEIQKEHFMDNAERHLAARVKVSGGQVY
VGQDLNKVLIHAEDEAKQMGDEYVSVEHLFLALIKYPNKALKEIFKEYGITRERFLQALSTVRGNQRVTSDNPEATYDTL
EKYGYDMVARARDQKLDPVIGRDDEIRNVVRILSRKTKNNPVLIGEPGVGKTAVVEGLAQRIVKGDVPEGLKDKKLFALD
MGALIAGAKYRGEFEERLKAVLDEVKSSEGQIILFIDELHTIVGAGKTDGAMDAGQLLKPMLARGELHCIGATTLDEYRE
YIEKDAALERRFQPVMVDEPTVEDTISILRGLKERYEVFHGVKITDSALVSAAVLSNRYISDRFLPDKAIDLVDEACALI
KTELDSMPTELDELNRRVMQMEIEETALKKETDRLSQERLANLQKELAELRDEFNTKKAQWENEKKSVEKVQKLREEIEA
VKNEIKMAQQKYDLEKAAELQYGKLPQLQKQLEIEEEAVKKRDLSLVHENVSEEEIARIISRWTGIPVAKLTESERNKTL
HLDEELHKRVIGQDEGVTKVTEAIIRSKAGIKDPSKPIGSFLFLGPTGVGKTELAKALAASLFDDESNMVRLDMSEYMEK
YSVSRLIGAPPGYVGYDEGGQLTEAVRRKPYSVVLFDEVEKAHPDVFNVLLQVLDDGRITDSQGRTVDFKNTIIIMTSNL
GSAHLLEGIDANGDINPECEAAVMDELRGHFRPEFLNRLDEIIMFKPLTKDNIGNIINLLVADLNKRLADREITVELTDA
AKQYIVENGYDPIYGARPLKRFLQKHVETLSAKLILADKVREGDTILIDVSGNELTAAVKA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 2e-166 43
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 4e-106 42
aec27 YP_851418.1 ATPase Not tested PAI II APEC-O1 Protein 2e-105 42
aec27 AAQ96721.1 Aec27 Not tested AGI-1 Protein 1e-105 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
RHOM_03585 YP_004837771.1 heat shock protein ClpB-like protein VFG2076 Protein 5e-122 44
RHOM_03585 YP_004837771.1 heat shock protein ClpB-like protein VFG2084 Protein 3e-113 42