Gene Information

Name : Rhom172_1443 (Rhom172_1443)
Accession : YP_004825204.1
Strain : Rhodothermus marinus SG0.5JP17-172
Genome accession: NC_015966
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1249
EC number : 1.16.1.1
Position : 1646489 - 1648162 bp
Length : 1674 bp
Strand : -
Note : TIGRFAM: Mercuric reductase MerA; KEGG: rmr:Rmar_1388 mercuric reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Heavy metal transport/detoxification protein; Pyridine nucleotide-disulphide oxidoreductase, dimerisation

DNA sequence :
ATGAAGAAGATCCTGGAATTGCGGATCGAAGGAATGACCTGCGCGCACTGCGCGCGCACGATCGAACAGGCGCTGTTGCG
TGTGCCCGGCGTGGTGCGCGCGCAGGTGCCCGGCTGGCAGAGCGGTCGGGCCGTGGTGACCTGGGAAGGCGACGCTGTCG
ATGCCGAAGCGCTCAGGGAGGCCGTGGCACAGGCCGGCCACGGGTACCGGCTGGAAGCGTGGGAGGTGGTGCGTGAGATC
GGTAGCGAAACGCCGGCCGGGGGCGGTTCGGATCGGGTCGATTACGATCTACTGATCATCGGCGGCGGCTCGGCGGCGTT
CGCGGCGGCGCTGCGGGCGCGGGAGCTGGGCTTCCGGACGCTGATCGTCAACGACGGCCTGCCGCCGGGCGGCACGTGCG
TGAACGTCGGCTGCGTGCCCTCGAAGGCGCTCATCCGGGCGGCCGAAGCACACCACCGGGCGGCCCATCATCCGTTTGCG
GGGATCCGTTCCAGCAGCCGGGTGGAGGACTTCGGCGCCGTGATCGGTCAGGTGCAGGCGCTCACCGACGAACTGCGTCA
GCACAAGTACCTGGATCTCATCGATGGCCGGCAGATCGTCTTTCGTGAAGGGCGGGCGCGGCTGGCCGGTCCGACCGCCA
TTCAGATCGGGGAGGAAACGATCACGGGCCGGGCCGTGCTGATCGCGACGGGTTCACGGACGGCGCTGCCGCCCGTTCCG
GGACTGGCCGACGGCCCTTATCTCACCAACGAGACGCTGTATCGTCTGTCCGTGCTGCCGGCGCACCTGATCGTACTGGG
CGGCGGCTACATCGGACTGGAAAACGCCCAGGCCTTTGCCCGGCTGGGCAGTCGGGTGACGGTGCTGGAGCTGCTGCCGC
AGATTCTTCCGCAGGAAGATTCCGACGTGGCCGAAGCGCTGACGACCTTCCTGCAGGCGGAAGGCATTGAGATCCGGACC
GAAGCGCGGGTGGTGCAGGTGGCCTGGCAGGAGGGGGGCGTGGTGGTCGCGTACGAGCACCAGGGCGCGACGCATCGGCT
GGCGGGCTCCCACCTGCTGGTGGCGACCGGCCGCCGGGGCAACACGGACGATCTGGGTCTGGAAGCGCTGGGCATAGCTA
CCGACCGGCAGGGCTTTCTGCAGGTGGACGATACGCTGCGGACGGCGGTGCCGACCGTGCTGGGGGCCGGCGACGTGATC
GGCAATCCGCCGTTCGTATACACGGCCGCCTACGAAGGCCAACTGGCCGCCGAGAATGCCCTGATGAATCGGCACGAGGT
GCGAGACTACAGCGCGCTGCCCTGGGTGGTCTTCACCGATCCCCAGGTGGCCGGGGTGGGTCTGAGTGAGCGCGAGGCGC
AGGCGGTCGGCATCGACTACGAAACGTCCGTGCTGCCGCTTTCGGAGGTGCCCCGGGCGCTGGTGGGTCGCGACACGCGC
GGGTTCGTCAAGCTGCTGCGCGATCCGGCCACGGACCGGCTGCTGGGCGCGCGGATCGTGGCGCCTGAAGGCGGCGAGCT
GCTCATGGAACTGTCGCTGGCGCTGCGCTACGAGATCACGGTCTCGGAGCTGGCCCGCCGCTTCCATCCCTATCTGACCT
GGTCCGAAGCCGTCAAGCTGGCCGCGCTGGGTTTCACGAAGGATGTGCGCCAGCTCAGCTGCTGCGCCGTGTGA

Protein sequence :
MKKILELRIEGMTCAHCARTIEQALLRVPGVVRAQVPGWQSGRAVVTWEGDAVDAEALREAVAQAGHGYRLEAWEVVREI
GSETPAGGGSDRVDYDLLIIGGGSAAFAAALRARELGFRTLIVNDGLPPGGTCVNVGCVPSKALIRAAEAHHRAAHHPFA
GIRSSSRVEDFGAVIGQVQALTDELRQHKYLDLIDGRQIVFREGRARLAGPTAIQIGEETITGRAVLIATGSRTALPPVP
GLADGPYLTNETLYRLSVLPAHLIVLGGGYIGLENAQAFARLGSRVTVLELLPQILPQEDSDVAEALTTFLQAEGIEIRT
EARVVQVAWQEGGVVVAYEHQGATHRLAGSHLLVATGRRGNTDDLGLEALGIATDRQGFLQVDDTLRTAVPTVLGAGDVI
GNPPFVYTAAYEGQLAAENALMNRHEVRDYSALPWVVFTDPQVAGVGLSEREAQAVGIDYETSVLPLSEVPRALVGRDTR
GFVKLLRDPATDRLLGARIVAPEGGELLMELSLALRYEITVSELARRFHPYLTWSEAVKLAALGFTKDVRQLSCCAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
merA AGK07079.1 MerA Not tested SGI1 Protein 2e-70 42
merA ABQ57371.1 MerA Not tested SGI1 Protein 2e-70 42
merA AGK07021.1 MerA Not tested SGI1 Protein 2e-70 42
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 5e-68 41
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 7e-71 41
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 2e-69 41
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 2e-69 41
merA AFG30120.1 MerA Not tested PAGI-2 Protein 2e-69 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Rhom172_1443 YP_004825204.1 mercuric reductase BAC0653 Protein 2e-72 43
Rhom172_1443 YP_004825204.1 mercuric reductase BAC0649 Protein 1e-98 43
Rhom172_1443 YP_004825204.1 mercuric reductase BAC0650 Protein 6e-62 42