Gene Information

Name : SACTE_0742 (SACTE_0742)
Accession : YP_004801213.1
Strain : Streptomyces sp. SirexAA-E
Genome accession: NC_015953
Putative virulence/resistance : Virulence
Product : AMP-dependent synthetase and ligase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : -
Position : 842382 - 844046 bp
Length : 1665 bp
Strand : +
Note : PFAM: AMP-dependent synthetase and ligase; KEGG: sco:SCO7681 AMP-binding ligase

DNA sequence : 
ATGACCGAGACTGAACAGCGCTGGCCCGAGGCGGAATCGGCGCGCTACCGGGCCGTCGGCCACTGGCAGGGGGTCACCTT
CGGCGCACGCCTGCGGCGGGCGGCGGCGGACCACGGCAGCCGTGTCGCCCTGGTCGACGGAGACCGCCGGTGGACATACG
CGGACCTGGACGCCGAGGCCGACCGCGTCGCCCACGGACTGCGCGGGCTCGGCGTCGGGCAGGGCGACCGCGTCGTGGTC
CAGCTCCCCAACCGTGCCGAGTTCGTGCTCGTCTGGTTCGGGCTGCAGCGCCTCGGAGCGGTCCCGGTGCACGCCATGCC
CGGCCACCGGCGCCGGGAGATCGGTCATCTGGTGCGCGTGTCCGGTGCGGTGGCCTGTGTGGTGCCCGACCGGCACGCGC
GGTTCGACCACCGTGACCTGATGCGCTCGGTGCGGGCGGAGAGCGGGCCGAACCGCTCGCCGCTGACGGTCGTGGTGGTC
GGCGATCCCGGCCAGGAGGACGGATTCGTCTCGTTCGAGGCGCTGCGGGCGGCTCCTCCCTCGTCGCCCGGTCACACCTC
GCCGGACGCTCTGCCGACCGCGGCCGACGACGACGGCGGAGCGGACCCCGGCGACGTCGCCCTCCTGCTGCTGTCCGGCG
GCACCACCGGCCTTCCCAAGCTCATCCCGCGCACGCACGACGCCTACGCGTACAACGCCCGCGCGTGCGCCGAGGTCTGC
GCACTCGACGACCGGACCGTCTATCTGGCGGTGCTGCCGCTCGGCTTCAACTTCGCCTTCGCCTGCCCCGGCGTACTCGG
CACCCTCATGGCCGGCGGTACGGTCGTGGTCGCCCCGGATCCCAGCCCGCAGACGGCGTTCGCCCTCGTCGAGCGGGAGG
GCGTGACCCTGACCTCCCTCACGCCCCCGCTCGTCTCCCCCTGGATGGACGAGGCCGCCTCCGGCTCCTGGGACCTCGCC
GGCCTCGCCGTGGTGCAGGTGGGCGGGGCCCGGCTGCCGGAGGAGCAGGCCCGGAAGCTCGGCCCGGCACTCGGAGTGAC
CGTGCAGCAGGTCTTCGGCATGGCGGAGGGGTTGATCAACCTCACGCGGCTCGATGATCCCGAGGACCTCGTCTGCGCCA
CCCAGGGCCGTCCCGTCTCGCCGGACGACGAGATCCTGGTGGTGGACACCGACGGCGGGCCCGTGCCGGACGGGTCGGCG
GGTGAACTGCTCACCCGGGGCCCGTACACGCTGCGTGGCTACTACCGCGCCGAGGAGCACGACCGCACGGCGTTCACACC
GGACGGCTACTACCGGACCGGCGACGTGGTGCGGCGGCTGCCGTCAGGGCACCTCGTCGTGGTGGGTCGGATCAAGGACC
AGATCAACCGCGGTGGCGAGAAGATCGCCGCGGTCGAGGTGGAGGAGCAGCTGCTCGTACATCCGGCGATCACCGCGGCC
GCACTGGTGGGTGTGCCGGACGAGCACAGGGGTGAGCGGACCGTCGCCTTCGTGGTCTGCGACGGCGAGGCTCCCGGCGT
GCGGGAGGTGGCCGCCCATCTGAAGGAGCGCGGACTCGCCGAGTACAAGGCGCCGGACGAGGTCGTCCAGGTGTCCGGCC
TCCCGCTCACCGCCGTCGGGAAGGTCGACAAGGCCACGCTGGCACGGGAGTTGCTCCGCCCGTGA

Protein sequence : 
MTETEQRWPEAESARYRAVGHWQGVTFGARLRRAAADHGSRVALVDGDRRWTYADLDAEADRVAHGLRGLGVGQGDRVVV
QLPNRAEFVLVWFGLQRLGAVPVHAMPGHRRREIGHLVRVSGAVACVVPDRHARFDHRDLMRSVRAESGPNRSPLTVVVV
GDPGQEDGFVSFEALRAAPPSSPGHTSPDALPTAADDDGGADPGDVALLLLSGGTTGLPKLIPRTHDAYAYNARACAEVC
ALDDRTVYLAVLPLGFNFAFACPGVLGTLMAGGTVVVAPDPSPQTAFALVEREGVTLTSLTPPLVSPWMDEAASGSWDLA
GLAVVQVGGARLPEEQARKLGPALGVTVQQVFGMAEGLINLTRLDDPEDLVCATQGRPVSPDDEILVVDTDGGPVPDGSA
GELLTRGPYTLRGYYRAEEHDRTAFTPDGYYRTGDVVRRLPSGHLVVVGRIKDQINRGGEKIAAVEVEEQLLVHPAITAA
ALVGVPDEHRGERTVAFVVCDGEAPGVREVAAHLKERGLAEYKAPDEVVQVSGLPLTAVGKVDKATLARELLRP

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 8e-88 44
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 6e-88 44
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 2e-87 43
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 2e-87 43
ybtE CAA21394.1 - Virulence HPI Protein 2e-87 43
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 2e-87 43
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 2e-87 43
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 2e-87 43
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 2e-87 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SACTE_0742 YP_004801213.1 AMP-dependent synthetase and ligase VFG1817 Protein 1e-97 46
SACTE_0742 YP_004801213.1 AMP-dependent synthetase and ligase VFG0168 Protein 8e-100 45
SACTE_0742 YP_004801213.1 AMP-dependent synthetase and ligase VFG0932 Protein 8e-92 42