Gene Information

Name : SACTE_0646 (SACTE_0646)
Accession : YP_004801123.1
Strain : Streptomyces sp. SirexAA-E
Genome accession: NC_015953
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 735483 - 737204 bp
Length : 1722 bp
Strand : -
Note : TIGRFAM: urease, alpha subunit; KEGG: sgr:SGR_6297 urease subunit alpha; PFAM: amidohydrolase; Urease alpha-subunit domain protein

DNA sequence :
ATGCCTGAACTCAGCCGCCCCGTCTACGCCGACCTGTTCGGGCCGACCACGGGGGACCGCATACGCCTCGCCGACACCGA
CCTGGTCGTCGAGATCGAGGAGGACCGCTCGGGCGGACCCGGCCGGGCCGGTGACGAAGCCGTGTTCGGCGGCGGCAAGG
TGATCCGCGAATCCATGGGCCAGGCGCGGACCACCCGTGCGGAAGGCGCGCCCGACACCGTGATCACCGGTGCCGTCGTC
CTCGACCACTGGGGCGTCGTCAAGGCGGACATCGGGATACGCGACGGCCGGATCACCGGCATCGGCAAGGCGGGCAACCC
GGACACGATGGACGGGGTCCACCCCGACCTGGTCATCGGCCCGGAGACCGAGATCATCGCGGGCAACGGCAAGTTCGTCA
CCGCCGGCGCCATCGACGCCCACGTCCACTTCATCTCGCCGACCCTGGTCGACCAGGCCCTCTCCTCGGGCATCACCACC
CTCGTCGGCGGCGGCACCGGACCTTCCGAAGGGACCAAGGCCACCACCATCACCCCAGGCCCCTGGCATCTCGCCCGGAT
GTTCCGTGCGCTGGAGAACAGCCCGGTCAACATCGGGCTGCTGGGCAAGGGCAACACGACGTCCCGCGAGGCCATGCACT
CCCAACTACGGGCCGGCGCGCTGGGATTCAAGATCCACGAGGACTGGGGCGCCACCCCGGCCGTGATCGACGCGTGCCTG
GGCGTCTGCGAGGAGACCGGCGCCCAGCTCGCCATCCACACCGACACGCTCAACGAGGCCGGATTCGTCGCCGACACACT
GGCCGCGATCGCCGGCCGCTCCATCCACGCGTACCACACCGAGGGTGCCGGCGGAGGGCACGCCCCCGACATCATCAGCG
TCGTCTCGGAGCCCAACGTCCTGCCCAGCTCCACCAACCCGACCCGGCCGCACACCGTCAACACCATCGAGGAACACCTC
GACATGCTGATGGTCTGCCACCACCTCAACCCCGCCGTCCCGGAGGACCTCGCGTTCGCCGAGTCGCGGATCAGGCCCTC
GACCATCGCGGCCGAGGACATCCTCCACGACCTCGGCGCCATCTCGATCATCTCCTCCGACTCCCAGGCGATGGGACGCG
TCGGCGAGGTGATCCTGCGCACCTGGCAGACCGCCCACGTCATGAAGCGGCGCCGGGGGGCCCTGCCGGGCGACGGCCGC
GCCGACAACCACCGGGCACGTCGCTATATCGCCAAATACACCATCAACCCCGCGGTCGCCCAAGGGCTGGACCGCGAGAT
CGGCTCGGTCGAGACGGGCAAGCTCGCCGACCTGGTGCTGTGGGAACCCGCCTTCTTCGGCGTCAAACCGCAGACGGTGA
TCAAGGGCGGCCAGATCGCCTACGCGCAGATGGGGGACGCCAACGCCTCGATCCCCACCCCGCAGCCCGTCATGCCACGC
CCCATGTTCGGCGCGATGGGCCGGGCCCCCGCCGCCAACTCCGTCACCTTCGTCTCGGCCGCGGCCGTCGAGGACGGGCT
GGCCGAGCGCCTCGGGCTGGAGAAGGAGTTCGTGCCGATCACCAGCACCCGGGGCGTCACCAAGGCGGACATGCGGGAGA
ACGACGCCCTGCCCAGGGTCGAGGTCGACCCCGACAGCTTCGCGGTCACCATCGACGGAGAGCCGGTCGAGCCCGCGCCC
GCCGCCGAACTCCCCATGGCCCAGCGCTATTTCCTCTTCTGA

Protein sequence :
MPELSRPVYADLFGPTTGDRIRLADTDLVVEIEEDRSGGPGRAGDEAVFGGGKVIRESMGQARTTRAEGAPDTVITGAVV
LDHWGVVKADIGIRDGRITGIGKAGNPDTMDGVHPDLVIGPETEIIAGNGKFVTAGAIDAHVHFISPTLVDQALSSGITT
LVGGGTGPSEGTKATTITPGPWHLARMFRALENSPVNIGLLGKGNTTSREAMHSQLRAGALGFKIHEDWGATPAVIDACL
GVCEETGAQLAIHTDTLNEAGFVADTLAAIAGRSIHAYHTEGAGGGHAPDIISVVSEPNVLPSSTNPTRPHTVNTIEEHL
DMLMVCHHLNPAVPEDLAFAESRIRPSTIAAEDILHDLGAISIISSDSQAMGRVGEVILRTWQTAHVMKRRRGALPGDGR
ADNHRARRYIAKYTINPAVAQGLDREIGSVETGKLADLVLWEPAFFGVKPQTVIKGGQIAYAQMGDANASIPTPQPVMPR
PMFGAMGRAPAANSVTFVSAAAVEDGLAERLGLEKEFVPITSTRGVTKADMRENDALPRVEVDPDSFAVTIDGEPVEPAP
AAELPMAQRYFLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 1e-163 61
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 1e-163 61
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 4e-151 59
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-151 59
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 1e-151 59
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-151 59

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SACTE_0646 YP_004801123.1 urease subunit alpha VFG0270 Protein 4e-144 57