Gene Information

Name : SACTE_5412 (SACTE_5412)
Accession : YP_004805761.1
Strain : Streptomyces sp. SirexAA-E
Genome accession: NC_015953
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 6117481 - 6119184 bp
Length : 1704 bp
Strand : +
Note : TIGRFAM: urease, alpha subunit; KEGG: sgr:SGR_236 urease subunit alpha; PFAM: amidohydrolase; Urease alpha-subunit domain protein

DNA sequence :
ATGGCACAGCTGACCCGTGCCGCCTACGCGGCGCTGTACGGCCCCACCACCGGCGACCGTGTCCGGCTCGCCGACACCGA
CCTGTGGATCGAGGTGGAGGAGGACCGCTGCTTCGGCGGCGACGAGGCCGTCTTCGGCGGAGGCAAGTCCATCCGCGAGT
CGATGGCCCAGGCCACCACCTCCGGCGCCGACGGCGCGCTCGACCTCGTCGTCACCAACGCGGTCGTCCTCGACCACTGG
GGGGTCGTCAAGGCCGACGTGGGCGTCCGCGCCGGACGGATCGTCGCCCTGGGCCGCTCCGGCAACCCCGACATCAGCGA
CGGCGTCCACCCTGACCTGGTCATCGGCCCCGGCACCGACGTCGTCTCCGGTGAGGGCCGCGTCCTCACCGCGGGAGCCG
TCGACACCCACGTGCACTTCCTGATGCCGGAGACCCTCCACGAGGCGCTCGCCACCGGCACCACCACCGTGATCGGCGGC
GGCACCGGCGCCTCCGAGGGATCCAAGGCCACCACCGTCACCCCGGGCACCTGGAACCTCGCGATGATGCACCGGTCCCT
GGACCGGATCCCGCTCAACGTCATGCTCTTCGGCAAGGGCTCCACCGTCGGCGAGGACGGGCTGCGCGAGGCCGCGCTCG
GCGGGGCCGGCGGCTACAAGGTCCACGAGGACTGGGGCGCGACGCCCGCCGCGATCGACGCCGCCCTGCGCGCCGCCGAC
ACCTACGGACTCCAGGTCGCCCTGCACGCCGACAGCCTCAACGAGGCCGGCTACGTCGAGCGGACGCTCGCCGCGATCGG
CGGACGCGGCATCCACGTGTTCCACGCCGAAGGCGCCGGCGGCGGCCACGCCCCCGACATCATCACCGTGGCCTCGCACC
CCCACATCCTCCCGGCGTCCACCAACCCGACCCTCCCGCACACCGTCAACACCGTCGCCGAACACCTCGACATGCTGATG
GTCTGTCACCACCTCAACCCCCGGGTGCCGGAGGACCTCGCCTTCGCCGAGTCCCGCATCCGGGCCACCACCATCGCCGC
GGAGGACGTGCTGCACGACCTCGGCGCACTCTCCATCACCTCGTCCGACGCCCAGGCCATGGGGCGCGTCGGTGAAGTCA
TCAGCCGTACCTGGCAGGTGGCCCACGTGATGAAGCGGCGCTTCGGCGACCGGGGCACCCTGCTCGCCGCGGACAACGAA
CGCGCACGTCGCTATGTCGCCAAGTACACGATCTGCCCGGCCGTCGCCCACGGCATCGACCACGTCGTCGGTTCCGTCGA
ACCCGGCAAGCTCGCCGACCTGGTGCTGTGGGACCCGGCGTTCTTCGGGATCCGCCCGGCCGCGGTCATCAAGGGCGGCA
TGGTCGTCCACGCGCCCCTCGGCGACGCCAACGCGGCCATCCCCACCACCCAGCCCGTCCTGCTGCGCCGCACCGCCGCC
GCCGGGGCCGCCCCGCACCTGTCGGTCAGCTTCGTCGCCCCGGCGGCCCTGGAGGACGGCCTCGCCGAACGCCTCGGCCT
GGAACGCGAACTGGTGGCCGTCCGCCCCACCCGCCACCTGACCAAGGCGGACCTGCCGAACAACACGGCGCTGCCCGCCA
TCGACGTGGACCCCGAGACCTTCGCCATCCGCGTCGACGGCGACCTCGTCGAGCCCTCCCCGGCCACCGAACTGCCGCTC
GCCCAGCGGTACAGCATGTTCTGA

Protein sequence :
MAQLTRAAYAALYGPTTGDRVRLADTDLWIEVEEDRCFGGDEAVFGGGKSIRESMAQATTSGADGALDLVVTNAVVLDHW
GVVKADVGVRAGRIVALGRSGNPDISDGVHPDLVIGPGTDVVSGEGRVLTAGAVDTHVHFLMPETLHEALATGTTTVIGG
GTGASEGSKATTVTPGTWNLAMMHRSLDRIPLNVMLFGKGSTVGEDGLREAALGGAGGYKVHEDWGATPAAIDAALRAAD
TYGLQVALHADSLNEAGYVERTLAAIGGRGIHVFHAEGAGGGHAPDIITVASHPHILPASTNPTLPHTVNTVAEHLDMLM
VCHHLNPRVPEDLAFAESRIRATTIAAEDVLHDLGALSITSSDAQAMGRVGEVISRTWQVAHVMKRRFGDRGTLLAADNE
RARRYVAKYTICPAVAHGIDHVVGSVEPGKLADLVLWDPAFFGIRPAAVIKGGMVVHAPLGDANAAIPTTQPVLLRRTAA
AGAAPHLSVSFVAPAALEDGLAERLGLERELVAVRPTRHLTKADLPNNTALPAIDVDPETFAIRVDGDLVEPSPATELPL
AQRYSMF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 3e-140 58
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 3e-140 58
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 5e-127 55
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 3e-127 55
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 3e-127 55
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 3e-127 55

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SACTE_5412 YP_004805761.1 urease subunit alpha VFG0270 Protein 7e-124 53