Gene Information

Name : SACTE_4615 (SACTE_4615)
Accession : YP_004804982.1
Strain : Streptomyces sp. SirexAA-E
Genome accession: NC_015953
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 5099386 - 5100813 bp
Length : 1428 bp
Strand : -
Note : TIGRFAM: pyruvate kinase; KEGG: sgr:SGR_2113 putative pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta

DNA sequence :
ATGCGCCGTTCCAAAATCGTCTGCACCCTCGGTCCCGCCGTCGACTCCCATGAGCAGCTCGTCGCTCTGATCGAGGCCGG
CATGAGCGTGGCCCGTTTCAACTTCAGCCACGGAACACACGAGGAGCACCAGGGCCGTTACGACCGCGTCCGCAAGGCCG
CCGCCGAGACCGGCCGCGCGGTCGGCGTGCTCGCCGACCTCCAGGGGCCGAAGATCCGCCTCGGGAAGTTCGCCGAGGGC
CCCGTCGAGCTGGTCCGGGGTGACGAGTTCGTCATCACCGCCGAGGACGTCCCGGGTGACAAGTCGATCTGCGGCACGAC
CTACAAGGGCCTGCCCGGTGACGTCACCAAGGGCGACCCGATCCTGATCAACGACGGCAACGTCGAGCTGAAGGTCGTCT
CCGTCGAGGGCCCCCGGGTCACCAGCATCGTCATCGAGGGCGGTGTCATCTCCGACCACAAGGGCATCAACCTGCCCGGC
GCGGCGGTCAACGTCCCGGCCCTGTCCGAGAAGGACGTCGAGGACCTGCGGTTCGCGCTGCGGATGGGCTGCGACCTGGT
CGCGCTGTCCTTCGTGCGGGACGCGGAGGACGTCAAGGACGTCCACAAGGTGATGGACGAGGAGGGCCGCCGGGTCCCCG
TCATCGCCAAGGTCGAGAAGCCGCAGGCCGTGGAGCACATGGAGGGCGTCGTCGCCGCCTTCGACGGTGTCATGGTGGCC
CGTGGCGACCTCGCCGTCGAGTACCCGCTCGAGAAGGTCCCGATGGTGCAGAAGCGCCTCATCGAGCTGTGCCGCCGCAA
CGCGAAGCCGGTGATCGTGGCGACCCAGATGATGGAGTCGATGATCACCAACTCCCGGCCGACGCGCGCCGAGGCGTCCG
ACGTGGCCAACGCGATCCTGGACGGCGCGGACGCGGTCATGCTGTCGGCGGAGTCCTCCGTGGGCGCGTACCCGATCGAG
ACGGTCAAGACGATGGCGAAGATCGTCGTCGCCGCCGAGGAGGAGCTGCTGTCCAAGGGCCTCCAGCCGCTCGTGCCGGG
CAAGAAGCCCCGCACCCAGGGCGGTTCGGTGGCCCGCGCGGCCGCCGAGATCGCGGACTTCCTGAACGGCAAGGCACTGG
TCGCCTTCACCAAGTCCGGCGACACGGCCCGCCGGCTGTCCCGCTACCGCGCGGCGCAGCCGATCCTGGCCTTCACCACG
GAGGAGTCCACCCGCAACCAGCTGGCCCTCAGCTGGGGTGTGGAGTCCTACGTCGTACCGCACGTGGACAACACGGACGC
GATGGTCGACCTGGTGGACGCGGAGCTGCTCAAGCTGAACCGCTACAACGACGGCGACACGATGGTCATCACGGCCGGTT
CGCCCCCCGGCGTCCCCGGCACCACCAACATGGTCCGGGTGCACCACCTGAGCGGCGAGCGCGGCTGA

Protein sequence :
MRRSKIVCTLGPAVDSHEQLVALIEAGMSVARFNFSHGTHEEHQGRYDRVRKAAAETGRAVGVLADLQGPKIRLGKFAEG
PVELVRGDEFVITAEDVPGDKSICGTTYKGLPGDVTKGDPILINDGNVELKVVSVEGPRVTSIVIEGGVISDHKGINLPG
AAVNVPALSEKDVEDLRFALRMGCDLVALSFVRDAEDVKDVHKVMDEEGRRVPVIAKVEKPQAVEHMEGVVAAFDGVMVA
RGDLAVEYPLEKVPMVQKRLIELCRRNAKPVIVATQMMESMITNSRPTRAEASDVANAILDGADAVMLSAESSVGAYPIE
TVKTMAKIVVAAEEELLSKGLQPLVPGKKPRTQGGSVARAAAEIADFLNGKALVAFTKSGDTARRLSRYRAAQPILAFTT
EESTRNQLALSWGVESYVVPHVDNTDAMVDLVDAELLKLNRYNDGDTMVITAGSPPGVPGTTNMVRVHHLSGERG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
pykA NP_273151.1 pyruvate kinase Not tested IHT-A Protein 1e-69 44
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 7e-79 42
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 7e-79 42
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 7e-79 42
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 2e-78 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SACTE_4615 YP_004804982.1 pyruvate kinase VFG0479 Protein 3e-79 42