Gene Information

Name : SACTE_1756 (SACTE_1756)
Accession : YP_004802206.1
Strain : Streptomyces sp. SirexAA-E
Genome accession: NC_015953
Putative virulence/resistance : Virulence
Product : AMP-dependent synthetase and ligase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : -
Position : 1960635 - 1962326 bp
Length : 1692 bp
Strand : -
Note : PFAM: AMP-dependent synthetase and ligase; KEGG: fal:FRAAL4648 (2,3-dihydroxybenzoyl)adenylate synthase (2, 3-dihydroxybenzoate-AMP ligase; dihydroxybenzoic acid-activating enzyme)

DNA sequence :
ATGATGCTCGACGGCTGCACACCGTGGCCCGCCGAGACGGCCGCGCGCTACCGCGGCACCGGCCTGTGGCAAGGCACCGA
CCTCGGTTCGTTGCCCCGGCTGTGGGCGGACACCTACGGCACGACCACGGCTCTCGTCGCGGGCCCGGACCGGATCAGCT
ACTCGGAGCTGGCGGACCGGGTGGACCGCACGGCCGCCGGATTCGTGCGCGAGGGAGTGCGTCCGGGCGACCGGATCGTG
CTCCAGCTGCCCAACACCGCCCGGTTCGTGGAGGTGGCCTTCGCCCTGTTCCGGGCCGGCGCCAAGCCGGTGTTCTCGCT
CACCTCGCACCGGGCCCAGGAGGTGCGCCATCTGTGCGAGCTGTCGGGGGCCTCCGGATACGTGGGACCCGGGGTCTTCC
GCGGCTTCGACCACACCGCCCTCGCCCGGCGGCTGGCCGCTGAGCTCCCCGGTCTGCGCATGGTGGTCGACATGGGCGAC
GGACCGGTCCCCGAGGGTGCCGTCCCGGCGTCCGGGATCGATGCCGAACCGCTGCCGCTGCCCGCGAACGACCCGTCCGA
CGTGGCCTTCTTCCTGCTGTCGGGCGGCACGACCGCACTGCCGAAGCTCATCCCGCGCACCCACGACGACTACGCGTACC
AGACCCGCACGGTGGCGGAGCTCTCCGGCCTCGGCCCCGGATCGGTCTATCTCGCCGCGCTCCCGGTCGAGTTCAACTTC
ACCTGGGGCTGCCCCGGAGTGGTCGGCACGCTGTCGTCCGGGGGCACGGTCGTGCTCGCCCCCGACGCCACCGCCGACGT
CTGCTTCCGGCTGATCGAGAGGGAACGCGTCACCCTGACCTCGGCGGTGCCCACGGTGGCCCGGCTCTGGCTGGAGGAGC
GCCAGTGGTCGGACGCCGACCTGTCCAGCCTCCAGGTCCTGCAGATCGGTGGCGCCCGGCTCGAACCGGAGCTGGCCGCA
CGGATCACCCCCGAACTCGGCTGCCGCCTCCAGCAGGTGTTCGGTATGGCCGAGGGCCTGCTCAGCATGGGCCGTGCGGA
CGACGACCCGCACTCGGTGCTGCACACCCAGGGCCGGCCGGTGTCACCGGCCGACGAGATCCGGATCGTCGACGCGTCCG
ACGCCCCGGTCCCGCCCGGCGTCACGGGGGAGCTGCTGACCCGTGGCCCGTACACCCTGCGCGGCTACTACCGGGCCCCC
GGGCACAACGCCGTCGCCTTCACCGAGGACGGCTTCTACCGCACCGGGGACCTGGCGAGCCTCACTCCCGAGGGACGCCT
CGTCGTCGAGGGCCGGATCAAGGACGTCGTCGTCCGGGGCGGCGACAAGATCGCCGCCGGTGAGGTGGAGGCCCACCTCC
TGGCCGTCCCCGGCATCGCCGCCGCGGCCGTGGTGCCGGTGCCTGACGAGTTCCTCGGGGAGCGGATCTACGCCTTCCTC
GTCAGCCGTGACGAGCCGGGCGCGGTGCCGCCGCTGAGCCTGCTCAAGGCCACCCTGCACCAGCGGGGGCTGGCCGACTT
CAAACTGCCGGACCGCGCCGAGTACGTCGCGGACCTGCCGCTCACACCGCTCGGAAAGATCGACAAGAAGGCCCTGTCGG
CGGCAGCCGCCGACCCGGCGCGATCCCGTGACTGGGGACAGGACCGGCCCGCCCCGGCCGCCGTCGCCGCCGCACCGATA
CCGACGAGGTGA

Protein sequence :
MMLDGCTPWPAETAARYRGTGLWQGTDLGSLPRLWADTYGTTTALVAGPDRISYSELADRVDRTAAGFVREGVRPGDRIV
LQLPNTARFVEVAFALFRAGAKPVFSLTSHRAQEVRHLCELSGASGYVGPGVFRGFDHTALARRLAAELPGLRMVVDMGD
GPVPEGAVPASGIDAEPLPLPANDPSDVAFFLLSGGTTALPKLIPRTHDDYAYQTRTVAELSGLGPGSVYLAALPVEFNF
TWGCPGVVGTLSSGGTVVLAPDATADVCFRLIERERVTLTSAVPTVARLWLEERQWSDADLSSLQVLQIGGARLEPELAA
RITPELGCRLQQVFGMAEGLLSMGRADDDPHSVLHTQGRPVSPADEIRIVDASDAPVPPGVTGELLTRGPYTLRGYYRAP
GHNAVAFTEDGFYRTGDLASLTPEGRLVVEGRIKDVVVRGGDKIAAGEVEAHLLAVPGIAAAAVVPVPDEFLGERIYAFL
VSRDEPGAVPPLSLLKATLHQRGLADFKLPDRAEYVADLPLTPLGKIDKKALSAAAADPARSRDWGQDRPAPAAVAAAPI
PTR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 1e-102 49
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 1e-102 49
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-102 49
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 1e-102 49
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-102 49
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-102 49
ybtE CAA21394.1 - Virulence HPI Protein 1e-102 49
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 4e-102 48
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 3e-102 48
irp2E YP_005134497.1 siderophore biosynthetic protein Virulence Not named Protein 5e-64 41
irp2E YP_005163485.1 siderophore biosynthetic protein Virulence Not named Protein 5e-64 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SACTE_1756 YP_004802206.1 AMP-dependent synthetase and ligase VFG0168 Protein 4e-105 49
SACTE_1756 YP_004802206.1 AMP-dependent synthetase and ligase VFG1817 Protein 2e-93 46
SACTE_1756 YP_004802206.1 AMP-dependent synthetase and ligase VFG0932 Protein 3e-89 43