Gene Information

Name : SPPN_01485 (SPPN_01485)
Accession : YP_004767601.1
Strain : Streptococcus pseudopneumoniae IS7493
Genome accession: NC_015875
Putative virulence/resistance : Resistance
Product : erythromycin ribosome methylase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0030
EC number : -
Position : 239535 - 240272 bp
Length : 738 bp
Strand : +
Note : COG0030 Dimethyladenosine transferase (rRNA methylation)

DNA sequence :
ATGAACAAAAATATAAAATATTCTCAAAACTTTTTAACGAGTGAAAAAGTACTCAACCAAATAATAAAACAATTGAATTT
AAAAGAAACCGATACCGTTTACGAAATTGGAACAGGTAAAGGGCATTTAACGACGAAACTGGCTAAAATAAGTAAACAGG
TAACGTCTATTGAATTAGACAGTCATCTATTCAACTTATCGTCAGAAAAATTAAAACTGAATACTCGTGTCACTTTAATT
CACCAAGATATTCTACAGTTTCAATTCCCTAACAAACAGAGGTATAAAATTGTTGGGAATATTCCTTACCATTTAAGCAC
ACAAATTATTAAAAAAGTGGTTTTTGAAAGCCGTGCGTCTGACATCTATCTGATTGTTGAAGAAGGATTCTACAAGCGTA
CCTTGGATATTCACCGAACACTAGGGTTGCTCTTGCACACTCAAGTCTCGATTCAGCAATTGCTTAAGCTGCCAGCGGAA
TGCTTTCATCCTAAACCAAAAGTAAACAGTGTCTTAATAAAACTTACCCGCCATACCACAGATGTTCCAGATAAATATTG
GAAGCTATATACGTACTTTGTTTCAAAATGGGTCAATCGAGAATATCGTCAACTGTTTACTAAAAATCAGTTTCATCAAG
CAATGAAACACGCCAAAGTAAACAATTTAAGTACCGTTACTTATGAGCAAGTATTGTCTATTTTTAATAGTTATCTATTA
TTTAACGGGAGGAAATAA

Protein sequence :
MNKNIKYSQNFLTSEKVLNQIIKQLNLKETDTVYEIGTGKGHLTTKLAKISKQVTSIELDSHLFNLSSEKLKLNTRVTLI
HQDILQFQFPNKQRYKIVGNIPYHLSTQIIKKVVFESRASDIYLIVEEGFYKRTLDIHRTLGLLLHTQVSIQQLLKLPAE
CFHPKPKVNSVLIKLTRHTTDVPDKYWKLYTYFVSKWVNREYRQLFTKNQFHQAMKHAKVNNLSTVTYEQVLSIFNSYLL
FNGRK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed BAC53825.1 rRNA adenine N-6-methyltransferase Not tested SRImec-III and SCCmec-III region Protein 2e-53 52
ermA BAC57474.1 rRNA methylase Not tested Type-IIIinv SCCmec Protein 6e-54 52
ermA1 YP_039522.1 rRNA adenine N-6-methyltransferase 1 Not tested Type-II SCCmec Protein 8e-54 52
ermA BAA82205.1 rRNA adenine N-6-methyltransferase Not tested Type-II SCCmec Protein 6e-54 52
ermA NP_370576.1 rRNA methylase Not tested Type-II SCCmec Protein 8e-54 52
ermA NP_373288.1 rRNA methylase Not tested Type-II SCCmec Protein 8e-54 52
ermA-3 YP_190052.1 rRNA adenine N-6-methyltransferase Not tested Type-II SCCmec Protein 8e-54 52
unnamed BAB47663.1 rRNA adenine N-6-methyltransferase Not tested Type-III SCCmec Protein 2e-53 52
ermC NP_273130.1 rRNA adenine N-6-methyltransferase Not tested IHT-A Protein 3e-57 51

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase AM903082.gene3.p01 Protein 1e-111 99
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase AM410044.gene14.p01 Protein 1e-111 99
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase AM180355.1.gene2259. Protein 8e-111 98
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase AM180355.1.gene2254. Protein 8e-111 98
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase NC_009782.5559229.p0 Protein 4e-54 52
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase NC_002758.1120012.p0 Protein 4e-54 52
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase NC_002952.2859614.p0 Protein 4e-54 52
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase NC_002745.1122822.p0 Protein 4e-54 52
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase NC_002745.1124324.p0 Protein 4e-54 52
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase NC_002745.1125313.p0 Protein 4e-54 52
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase AJ313523.1.orf0.gene Protein 8e-54 52
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase NC_009782.5559087.p0 Protein 4e-54 52
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase NC_002758.1121630.p0 Protein 4e-54 52
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase NC_002952.2859615.p0 Protein 4e-54 52
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase NC_002745.1123579.p0 Protein 4e-54 52
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase NC_002745.1124852.p0 Protein 4e-54 52
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase V01278.gene.p01 Protein 2e-58 52
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase M64090.gene.p01 Protein 3e-56 52
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase M15332.gene.p01 Protein 2e-53 51
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase NC_010685.6295744.p0 Protein 1e-57 51
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase NC_010686.6295746.p0 Protein 1e-57 51
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase NC_007209.3523503.p0 Protein 1e-57 50
SPPN_01485 YP_004767601.1 erythromycin ribosome methylase NC_007792.3912746.p0 Protein 5e-57 50