Gene Information

Name : MELS_1354 (MELS_1354)
Accession : YP_004766402.1
Strain : Megasphaera elsdenii DSM 20460
Genome accession: NC_015873
Putative virulence/resistance : Virulence
Product : ATP-dependent Clp protease ATP-binding subunit ClpC
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 1484685 - 1487117 bp
Length : 2433 bp
Strand : +
Note : -

DNA sequence :
ATGATGAACAATCGTCTCACCAATGATGCCAAAGCTGTCCTGCAGTATGCGCAGGAAGCGGCACAAAAATTCCACCATGA
TTACGTCGGGACCGAACATATCCTACTCGGTCTCGTTCTCAATACAGACGGCATTGCCGGCCTGCTCCTCAACCAGTTGG
GCCTGACGCCGGAAAATGTCACCCGCGCCATCGAACAGCACGTCGGCTGGGGACAGGATACGCCGTCGAAACTGCGCCTG
ACGCCGCGGACGAAGCGGGCCATGGAACTGGCCGTCCGCGAAGCCAACCGACTGGAACAGAACTATGTCGGCACGGAACA
CATGCTGGCCGGCATCCTCGAAGAAGGGAGCGGCATGGCCGTCCAGATCCTGGAAGATATGGACATCGACCCGGACCTCG
TCTCCCAACGCCTGAGTGAACTCATGAACGACCCGGCCGTCGAAGGCGGCGACGCCGTGGCTGCCAAGAACGGCAGCGAC
TTGTCCCAGTTCGGCCGTGATCTCAATGAATGGGCCAAGAAGGGCAAAATCGACCCGGTCATCGGCCGGGAAAAGGAAAT
CAGCCGGGTCATCCAGATCCTCAGCCGCCGGACCAAGAACAATCCGGTCCTCATCGGCGCACCTGGCGTCGGCAAGACGG
CCATTGCCGAAGGCCTGGCCCAGCGCATCATCAACGGCAACGTGCCTGACAGCCTGCTGGACAAGCGCATTTTCTCCCTC
GACCTGGCCAGCATCGTTGCCGGTACCAAGTACCGCGGCGAATTTGAAGAACGGATCAAGCGCATCCTCGACGTCATCGA
ACAGGACGATACCATCATCCTCTTCATCGACGAAATCCACCAGCTCATCGGCGCCGGTGCCGTCGAAGGGGCCATGGATG
CAGCCAATATCCTCAAACCGGCCCTGGCCCGGGGCGACCTGCAGTGCATCGGCGCTACGACCATCGACGAATACAAGAAA
CACTTTGAAAAAGATGCCGCTCTGGCCCGCCGTTTCCAGCCCGTCCTGGTCGGCGAACCGACGGAAGACGACGCCATGGC
CATCCTCTTCGGCCTGCGCGACCGCTACGAAGCCTTCCACAAGGCCCGTATCACGGACGACGCCGTAAGAGCCGCCGTCA
AATTGTCGGCACGGTACATTTCCGACCGCTATCTGCCGGACAAGGCCATCGACGTCATGGACGAAGCGGCAGCCCGCGTC
CGCATGAAGGTCTACGCGCCGTCCCATGAACTCCAGGACCTGGAACAGAAACTGGCTGATATCAATAAAGAAAAAGAAGC
GGCCCTGGCTGGGGAAGACTTCGAAAAATGCGCGTCCCTCCGCGATGCCGGCAAGAAGGTATCATCGGAAATCTCGGCTC
TTCAAAAAGAAAAGAAACAGCACGACGATGAAAAACTCGTCGTCACGGAAAACGACATTGCCGACGTCGTGTCCATGTGG
ACAGGCGTCCCGGTCCAGCAAATTACAGAAACGGAATCGCAGCGCCTCCTTCACTTAGAAGAAGAACTGCATAAACGGGT
CATCAGCCAGGATGACGCCGTCACGGCCGTAGCTAAAGCCGTCCGCCGGGCCCGAGCCGGCCTCAAGGATGCCAACCGCC
CCATCGGTTCCTTCCTCTTCCTTGGTCCGTCCGGTGTCGGCAAGACCGAACTGGCCCGGACCCTGGCCGCCCAGCTCTTC
GGCAGTGCCGACAACATGATCCGCATCGACATGAGCGAATTTATGGAAAAATACAGTGTCTCCCGCCTGGTCGGCGCCCC
TCCGGGCTATGTCGGCTATGAAGAAGGGGGCGAATTGACCGACGCAGTTCGGGAAAAACCGTACAGTGTCATCCTCTTCG
ACGAAGTGGAAAAGGCCAGCAGCGACTTCTTCAACCTGCTCCTGCAGGTCCTCGACGAAGGCCGCCTGACTGACTCCAAA
GGCCGGACCGTCGATTTCCGCAATACCGTCATCATCATGACCAGCAATCTCGGCGCATCGCACCTCAAACCGTCGGGCCC
GGTCATGGGCTTCTCGACGGGCGGCGACAGTGCCAAGGACCGGGAAGCGTCTTTCGAAGTCGCCAAGAAGGAAATCATGG
CCGATGTGAAACGCTTCTTCCGTCCGGAATTTCTCAACCGTATCGACGAAATCATCGTCTTCAAGCCGCTGGAACAGAAA
GACCTGCGCCAGATCGTCGACATCCTGCTCCAGGACCTGACGAAACGCCTTGGCGAAAAAGGCGTGGCCATGGATTGGAC
GACGGCCGCCGACGACATCCTCGTCAAAGAAGGCACGGACTTTGCCTATGGCGCCCGGCCGTTGAAACGGGCCATCCAGA
AGCTCGTCGAAGACCCGATTTCGGAAATGCTCCTCAGCGGCGACGTCAAGGACGGCAATACGATCCACGTCGACAGTTTG
GACAAGAAGAAACTCGTCTTTACGACGGAGTAA

Protein sequence :
MMNNRLTNDAKAVLQYAQEAAQKFHHDYVGTEHILLGLVLNTDGIAGLLLNQLGLTPENVTRAIEQHVGWGQDTPSKLRL
TPRTKRAMELAVREANRLEQNYVGTEHMLAGILEEGSGMAVQILEDMDIDPDLVSQRLSELMNDPAVEGGDAVAAKNGSD
LSQFGRDLNEWAKKGKIDPVIGREKEISRVIQILSRRTKNNPVLIGAPGVGKTAIAEGLAQRIINGNVPDSLLDKRIFSL
DLASIVAGTKYRGEFEERIKRILDVIEQDDTIILFIDEIHQLIGAGAVEGAMDAANILKPALARGDLQCIGATTIDEYKK
HFEKDAALARRFQPVLVGEPTEDDAMAILFGLRDRYEAFHKARITDDAVRAAVKLSARYISDRYLPDKAIDVMDEAAARV
RMKVYAPSHELQDLEQKLADINKEKEAALAGEDFEKCASLRDAGKKVSSEISALQKEKKQHDDEKLVVTENDIADVVSMW
TGVPVQQITETESQRLLHLEEELHKRVISQDDAVTAVAKAVRRARAGLKDANRPIGSFLFLGPSGVGKTELARTLAAQLF
GSADNMIRIDMSEFMEKYSVSRLVGAPPGYVGYEEGGELTDAVREKPYSVILFDEVEKASSDFFNLLLQVLDEGRLTDSK
GRTVDFRNTVIIMTSNLGASHLKPSGPVMGFSTGGDSAKDREASFEVAKKEIMADVKRFFRPEFLNRIDEIIVFKPLEQK
DLRQIVDILLQDLTKRLGEKGVAMDWTTAADDILVKEGTDFAYGARPLKRAIQKLVEDPISEMLLSGDVKDGNTIHVDSL
DKKKLVFTTE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 0.0 51

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
MELS_1354 YP_004766402.1 ATP-dependent Clp protease ATP-binding subunit ClpC VFG0079 Protein 0.0 55
MELS_1354 YP_004766402.1 ATP-dependent Clp protease ATP-binding subunit ClpC VFG0080 Protein 5e-142 51