Gene Information

Name : entE2 (CVAR_2845)
Accession : YP_004761258.1
Strain : Corynebacterium variabile DSM 44702
Genome accession: NC_015859
Putative virulence/resistance : Virulence
Product : 2,3-dihydroxybenzoate-AMP ligase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : 2.7.7.58
Position : 3203781 - 3205355 bp
Length : 1575 bp
Strand : -
Note : Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

DNA sequence : 
ATGGCAGTGACGCCTGTGCCCGTGGACGGTGTGGTCCCGTACCCTGTGGAGTTCGCCGAGAAGTACCGGTCCGCCGGGTA
CTGGACCGGGCAGACCCACACCGACATGTTCGCCGCGACCGTCGCGCGGTTCCCCGACAGGACAGCCGTCATTTCCGGGG
ACCGGGAGATGACCTACGCCGAACTCGGTGACCGGGTCCGCCGGTTGGCCGCTGGCTTCCTGGACCGGGGTCTGGAACGC
GGTGACCGGGTGGTCGTGCACCTGCCGAACATCCCCGAGTATCTGGAGACGGTTTTCGCCCTCTGGGAGATCGGAGCTGT
TCCGGTCTTCGCCCTTGCCGCGCACACAGCCCGCGAGATCAGCTACTTCATCGAGTTCTCCGGAGCACGTGGCTACATCA
CGGACACCCTGCCGGAGGGGAAGCTTCCTTCCCTGGACTTCTGCTGGACCGTTAACGACAGCAGTTTCGCTGGACTCGCC
GCCGGCGAACCGCTGGTGCACGCACAGCGCAGCAACCCGGCGGATATCGCCTTCCTCCAGCTCTCGGGCGGGACCACGGG
GCTTCCCAAGATGATCCCCCGGACGCACGACGACTACCTCTACTCGGTCAGGGCGAGCAACGAGATCTGCGATATCACCC
AGCACACAGTGCAGCTGGTCGTGCTGCCGATCTCGCACAACTTCACCATGAGTTCGCCGGGTGTGCTCGGAGCCGTAATG
GCGGGGGCGACCATGGTCCTCGCCCCGGACGGCATGCCGGAGACGGCGTTCCCCCTCATCGAGAAGCACCGGGTCACCCA
GAGTCAACTGGTACCGCCGCTGGCTCTGCTGTGGCTGAACTCTCCGCTCAAGGACGGTTACGATCTCTCCAGCCTGGAGA
CCCTCCAGGTCGGTGGGGCGAAGTTCAGCGAGGAGGCTGCGTGCCGGGTGGGTCCGGAACTCGGGGTGACCCTGCAGCAG
GTCTTCGGCATGGCTGAGGGCCTGGTGAATTACACTCGGCTCAATGATGCTCCCGCCACCATCGCCGCGACCCAGGGACT
GCAAATGTCTCCTGATGATGAGGTTCGGGTGGTGGATGCCGCAGACAACGACGTTCCGGCCGGTACCCCGGGCGATCTGC
TGATCCGGGGCCCGTACACGATCCGGGGTTATTTCCGCGCTCCGGAGGTGAACCGGCGGAGCTTCACTGAAGACGGCTTC
TACCGCACCGGCGATGTGGTGCGCATGGATGAACGCGGGTACCTCACCGTGCTGGGTCGGTCGAAGGACCAGATCAACCG
GGGTGGGGAGAAGATTTCCCCGGAGGAGGTGGAGAACCTCCTGCTCGGCCATGAGGGCATCCACGATGTCTCGGTGGTCG
GAGTACCGGACGATGATCTGGGGGAACGGACCAGGGCCTACATCATCCCCCGGGAAGGTGTCGATCCTGCCGGTCTGGGT
GTGCTGGCGGTCAAGCGGTTCCTCCGGGACCGCGGTCTGGCGGCCTTCAAGATCCCGGACATGATTGAGTTCGTCGATGA
GTTCCCGCAGACCGCGGTCGGCAAGGTGAGCAAGCGCGACCAGCGGGAGGAGTAG

Protein sequence : 
MAVTPVPVDGVVPYPVEFAEKYRSAGYWTGQTHTDMFAATVARFPDRTAVISGDREMTYAELGDRVRRLAAGFLDRGLER
GDRVVVHLPNIPEYLETVFALWEIGAVPVFALAAHTAREISYFIEFSGARGYITDTLPEGKLPSLDFCWTVNDSSFAGLA
AGEPLVHAQRSNPADIAFLQLSGGTTGLPKMIPRTHDDYLYSVRASNEICDITQHTVQLVVLPISHNFTMSSPGVLGAVM
AGATMVLAPDGMPETAFPLIEKHRVTQSQLVPPLALLWLNSPLKDGYDLSSLETLQVGGAKFSEEAACRVGPELGVTLQQ
VFGMAEGLVNYTRLNDAPATIAATQGLQMSPDDEVRVVDAADNDVPAGTPGDLLIRGPYTIRGYFRAPEVNRRSFTEDGF
YRTGDVVRMDERGYLTVLGRSKDQINRGGEKISPEEVENLLLGHEGIHDVSVVGVPDDDLGERTRAYIIPREGVDPAGLG
VLAVKRFLRDRGLAAFKIPDMIEFVDEFPQTAVGKVSKRDQREE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 3e-92 44
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 4e-92 44
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 9e-93 44
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 1e-92 44
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-92 44
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 1e-92 44
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-92 44
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-92 44
ybtE CAA21394.1 - Virulence HPI Protein 1e-92 44

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
entE2 YP_004761258.1 2,3-dihydroxybenzoate-AMP ligase VFG0168 Protein 6e-121 51
entE2 YP_004761258.1 2,3-dihydroxybenzoate-AMP ligase VFG0932 Protein 3e-99 45
entE2 YP_004761258.1 2,3-dihydroxybenzoate-AMP ligase VFG1817 Protein 1e-85 42