Gene Information

Name : metB (CVAR_0151)
Accession : YP_004758572.1
Strain : Corynebacterium variabile DSM 44702
Genome accession: NC_015859
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 180170 - 181438 bp
Length : 1269 bp
Strand : +
Note : O-acetylhomoserine sulfhydrylase

DNA sequence : 
ATGACCAGCGCCGATCAGGCACAGCACGCCGAGCACGAGAACCGGGCGGACGCCGGTACCGCCGCGCGACGCGAGGCAGC
ACTCACGGCCGCTGCCCGCCTGACCGACGCCACCGGCCGTCCCTTCGGCTTCAACACCAACGCCATCCACTCCGGCTACG
AGCCGGACGGCCAGACCGGCGCGGTCAACGTGCCCGTCTACACCTCCACCACCTACGCCCAGGACGGGGTGGCACAGCTC
CGCGGCGGTTTGGAGTACTCCCGCTGCGGCAACCCGACCGTCACCGCCGTCGAGCAGGCCGTCGCCGCCCTGGAAGGTGC
CCGCTTCGGCCGCGCCTTCGGCTCCGGCATGGCCGCCACCGACACCCTGCTGCGCGCCCTGCTGCGTCCCGGAGACCACC
TGATCCTCGGATCCGACGCCTACGGCGGAACCTTCCGCCTCATCGACACCACCTACAGGGAATGGGGCGTCACCTGCTCC
ATCGTCGACACCGCCGATACCGCCCAGATCGCCGGCGCACTGCAGGAGAACACGAAGCTGGTCTGGCTGGAGACGCCGAC
CAACCCGATGCTCGGCATCACCGACATCGCCGCCACCGCCGCCGCGATCAAGGACGCCGGCCACGCCGCGAAGCTCGTCG
TCGACAACACCTTCGCCAGCCCCTACCTGCAGAATCCGCTGGCTCTCGGTGCGGACGTGGTGATGCACTCCACCACGAAG
TACCTCGGCGGACACTCCGACGTCGTCGGTGGCGTGGTCGTCACCAACGACGAGGATCTCGACGGTGAGCTGCTGTTCCT
GCAGGGTGGCGTGGGCGCGGTGCCCGGGCCCTTCGACGCCTACCTCACCTACCGCGGTATCAAGACCCTCGGTGTACGCA
TGGACCGCCACTGCGCGAATGCCCAGGCCGTCGCCGAGTTCCTGCAGTCCCGCCCCGAGATCCACACCGTCCTCTACCCG
GGCCTGCCGGACCACCCCGGCCACGACATCGCCGCGAAGCAGATGAAGGGCTTCGGCGCGATGGTGTCGGTCCGCTTCGC
CGGTGGCGAGGACGCCGCCCTGAAGTTCTGCGAGTCGACCCGGCTGATCTGCCTGGCGGAGTCGCTCGGTGGCGTGGAGT
CGCTGCTGGAGCACCCTGCGAAGATGACTCACCAGTCCGCCGCCGGCTCCGCTCTCGAGGTGCCCGACGACCTGGTGCGC
ATCTCCATCGGCATCGAGGACATCGACGACCTGATCGCCGACCTCACCCAGGCGCTCGACGCTCTGTGA

Protein sequence : 
MTSADQAQHAEHENRADAGTAARREAALTAAARLTDATGRPFGFNTNAIHSGYEPDGQTGAVNVPVYTSTTYAQDGVAQL
RGGLEYSRCGNPTVTAVEQAVAALEGARFGRAFGSGMAATDTLLRALLRPGDHLILGSDAYGGTFRLIDTTYREWGVTCS
IVDTADTAQIAGALQENTKLVWLETPTNPMLGITDIAATAAAIKDAGHAAKLVVDNTFASPYLQNPLALGADVVMHSTTK
YLGGHSDVVGGVVVTNDEDLDGELLFLQGGVGAVPGPFDAYLTYRGIKTLGVRMDRHCANAQAVAEFLQSRPEIHTVLYP
GLPDHPGHDIAAKQMKGFGAMVSVRFAGGEDAALKFCESTRLICLAESLGGVESLLEHPAKMTHQSAAGSALEVPDDLVR
ISIGIEDIDDLIADLTQALDAL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 5e-65 45
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 5e-64 45
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 1e-45 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
metB YP_004758572.1 cystathionine gamma-synthase BAC0207 Protein 6e-54 44