Gene Information

Name : ureC (MCAN_18651)
Accession : YP_004745310.1
Strain : Mycobacterium canettii CIPT 140010059
Genome accession: NC_015848
Putative virulence/resistance : Virulence
Product : urease alpha subunit ureC (urea amidohydrolase)
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : -
Position : 2136459 - 2138192 bp
Length : 1734 bp
Strand : +
Note : -

DNA sequence :
ATGGCGCGACTGTCAAGGGAGCGCTACGCACAGCTGTACGGACCTACCACCGGCGACCGGATACGGCTGGCCGACACCAA
CCTGCTGGTTGAGGTCACCGAAGACCGGTGTGGGGGACCGGGACTGGCCGGTGACGAGGCGGTGTTCGGCGGCGGCAAGG
TGCTGCGCGAGTCCATGGGCCAGGGCCGTGCGAGCCGGGCCGACGGTGCCCCCGACACCGTGATCACCGGTGCGGTGATC
ATCGACTACTGGGGAATCATCAAGGCCGACATCGGGATTCGCGATGGCCGCATCGTCGGGATCGGAAAGGCCGGCAATCC
CGACATCATGACAGGTGTGCATCGGGATCTCGTCGTCGGGCCGTCCACCGAAATCATCAGCGGCAACCGTCGAATCGTCA
CCGCAGGCACCGTCGACTGTCACGTGCACTTGATCTGTCCGCAGATCATCGTCGAAGCCTTGGCCGCGGGCACCACCACG
ATCATCGGCGGTGGCACCGGACCCGCCGAGGGCACCAAGGCCACCACAGTCACTCCCGGCGAGTGGCACCTGGCCCGGAT
GCTGGAGTCACTGGACGGTTGGCCGGTGAACTTCGCGCTGCTCGGCAAGGGAAACACCGTGAATCCCGACGCACTGTGGG
AACAGTTGCGCGGTGGCGCATCGGGTTTCAAACTCCACGAAGACTGGGGATCGACCCCGGCGGCCATCGACACCTGCTTG
GCGGTCGCCGACGTGGCCGGGGTGCAGGTTGCGCTGCACTCCGACACTCTCAATGAGACCGGATTCGTCGAGGACACCAT
CGGCGCGATCGCCGGACGTTCGATTCACGCCTACCACACCGAGGGCGCCGGCGGCGGGCACGCACCGGACATCATTACCG
TCGCGGCGCAACCGAATGTACTGCCCAGCTCGACCAATCCGACCCGCCCGCATACGGTGAACACCCTTGACGAGCATCTC
GACATGCTGATGGTGTGCCACCACCTCAACCCCCGGATCCCGGAGGACCTCGCGTTTGCCGAAAGCCGGATCCGACCGTC
CACCATTGCGGCAGAAGATGTGTTGCACGATATGGGGGCAATCTCGATGATTGGCAGCGATTCCCAGGCGATGGGCCGTG
TCGGCGAGGTGGTGCTGCGCACCTGGCAGACCGCGCACGTGATGAAAGCCCGCCGCGGGGCACTGGAAGGTGACCCGTCT
GGTAGCCAAGCCGCCGACAACAACCGGGTCCGCCGCTACATCGCCAAATACACCATCTGCCCGGCCATCGCACACGGCAT
GGATCACCTGATCGGTTCGGTGGAGGTGGGAAAGTTGGCCGACCTGGTGTTGTGGGAGCCGGCGTTTTTCGGGGTTCGCC
CGCACGTCGTGCTCAAAGGTGGGGCGATCGCCTGGGCGGCGATGGGCGATGCGAACGCGTCAATCCCGACCCCGCAACCG
GTGCTCCCGCGACCGATGTTCGGCGCGGCCGCGGCAACCGCGGCGGCGACCTCGGTGCACTTCGTCGCGCCGCAATCCAT
CGACGCGCGCCTGGCGGACCGGCTCGCGGTCAATCGGGGACTAGCGCCGGTGGCCGACGTGCGCGCAGTGGGCAAGACCG
ACCTGCCGCTCAATGATGCCCTACCGAGCATCGAGGTCGATCCCGACACCTTCACCGTGCGAATCGACGGCCAGGTGTGG
CAACCGCAGCCGGCCGCCAAACTACCTATGACACAACGGTATTTCCTGTTCTAA

Protein sequence :
MARLSRERYAQLYGPTTGDRIRLADTNLLVEVTEDRCGGPGLAGDEAVFGGGKVLRESMGQGRASRADGAPDTVITGAVI
IDYWGIIKADIGIRDGRIVGIGKAGNPDIMTGVHRDLVVGPSTEIISGNRRIVTAGTVDCHVHLICPQIIVEALAAGTTT
IIGGGTGPAEGTKATTVTPGEWHLARMLESLDGWPVNFALLGKGNTVNPDALWEQLRGGASGFKLHEDWGSTPAAIDTCL
AVADVAGVQVALHSDTLNETGFVEDTIGAIAGRSIHAYHTEGAGGGHAPDIITVAAQPNVLPSSTNPTRPHTVNTLDEHL
DMLMVCHHLNPRIPEDLAFAESRIRPSTIAAEDVLHDMGAISMIGSDSQAMGRVGEVVLRTWQTAHVMKARRGALEGDPS
GSQAADNNRVRRYIAKYTICPAIAHGMDHLIGSVEVGKLADLVLWEPAFFGVRPHVVLKGGAIAWAAMGDANASIPTPQP
VLPRPMFGAAAATAAATSVHFVAPQSIDARLADRLAVNRGLAPVADVRAVGKTDLPLNDALPSIEVDPDTFTVRIDGQVW
QPQPAAKLPMTQRYFLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 8e-147 62
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 8e-147 62
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-146 58
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-146 58
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 2e-146 58
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-146 58

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ureC YP_004745310.1 urease alpha subunit ureC (urea amidohydrolase) VFG0270 Protein 2e-131 55