Gene Information

Name : thyA (zobellia_870)
Accession : YP_004735326.1
Strain : Zobellia galactanivorans DsiJT
Genome accession: NC_015844
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 1043666 - 1044490 bp
Length : 825 bp
Strand : +
Note : Thymidylate synthase catalyzes the reductive methylation of dUMP to dTMP with concomitant conversion of 5,10-methylenetetrahydrofolate to dihydrofolate. This provides the sole de novo pathway for production of dTMP and is the only enzyme in folate metabol

DNA sequence :
ATGAAGCAATACCACGACTTACTAAAGCACGTACTCGATAACGGCAATCAAAAAGGAGACCGAACAGGAACAGGAACCCT
TAGCGTTTTCGGATATCAAATGCGTTTTGACCTCAGCGAAGGCTTCCCTATGGTAACTACTAAAAAGTTACACTTGAAGT
CTATTGTTTATGAATTGCTTTGGTTTTTGAAAGGTGATACGAACATTAAATACCTTCAAGAAAATGGTGTGCGTATCTGG
AACGAATGGGCCGATGAAAATGGCGATTTAGGTCCTGTTTATGGCCACCAATGGCGTAACTGGAACAATAATGAAATTGA
CCAGATCAAAGATGTTATTGAATCATTAAAAAACAACCCTAACAGTAGACGTATGTTGGTTTCCGCATGGAACCCGAGCG
TACTTCCCGATACATCAAAATCATTCTCTGAAAACGTAGCCAACGGTAAAGCTGCGCTTCCACCATGTCACGCTTTTTTC
CAATTTTACGTGGCCGACGGCAAGCTTTCATGCCAGTTATACCAACGCAGTGCGGATATCTTCCTAGGGGTACCTTTCAA
TATAGCCTCTTATGCCTTATTCACTATGATGATGGCACAGGTATGCGGCTATGAAGCGGGAGAATTTATCCACACTTTTG
GTGATGCCCATATTTACAACAACCATATGGAACAGGTAGAATTGCAATTGAGTCGTGAAACCCGTCCCCTACCCAAAATG
CTCATCAATCCTGAAGTAAAGGATATTTTTGACTTCAATTTTGAAGATTTTACCTTAGAGGATTACAACCCGCATCCACA
TATTAAAGGGGCCGTAGCGGTTTAA

Protein sequence :
MKQYHDLLKHVLDNGNQKGDRTGTGTLSVFGYQMRFDLSEGFPMVTTKKLHLKSIVYELLWFLKGDTNIKYLQENGVRIW
NEWADENGDLGPVYGHQWRNWNNNEIDQIKDVIESLKNNPNSRRMLVSAWNPSVLPDTSKSFSENVANGKAALPPCHAFF
QFYVADGKLSCQLYQRSADIFLGVPFNIASYALFTMMMAQVCGYEAGEFIHTFGDAHIYNNHMEQVELQLSRETRPLPKM
LINPEVKDIFDFNFEDFTLEDYNPHPHIKGAVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 1e-76 61