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Name : HsdM2 (zobellia_1657) Accession : YP_004736100.1 Strain : Zobellia galactanivorans DsiJT Genome accession: NC_015844 Putative virulence/resistance : Unknown Product : type I restriction enzyme ZgaDII, M subunit Function : - COG functional category : V : Defense mechanisms COG ID : COG0286 EC number : 2.1.1.72 Position : 1957856 - 1959457 bp Length : 1602 bp Strand : - Note : The type I restriction enzyme, M and S subunits together form a N-6 adenine methyltransferase (MTase) that methylates the amino group at the C-6 position of a adenine residue in a hemimethylated bipartite DNA recognition sequence, in order to prevent the DNA sequence : ATGGCCAAAGCAGATATTGATTTTGAAAAAGAACTATGGGATGCCGCCAACGAACTTCGTGGTGCGGTTTCCGAGAATAA CTATAAGAATTATATTTTACCATTGGTCTTTTTAAAACACCTCAGTGAGCGATTTGATATTGTAAAAGAGGAACTTGAAA ACACCTTGAACGAACCAAGTTCCGAGTATTACACTACCAATCATGAGGAAAAAGACTATGTATTGAGCGACCCGGACGAA TATCGTTCGCGTAATACGTTTATGATACCGAAAACCGCTTCTTGGCAGTATTTAAAGGATAACGCGGAGCAAGACGATAT CAAGGTAAAGGTAGATGACGCTTTTGATACCATCCAAGATTTACTTACCGCCTACAATCCGCAGCTGAACAACCTTCTAC CAAGAATATTTGTAAAGAGCGAACTTTCGGCAAAACAAACCGGTGGTATCATCAACCTGCTCTCCCATCCTAAATTCTCG GAAAAGGAAAACCCCGAGAGCGACATTCTAGGCCGTATCTACGAGTATTATATTGGCCGTTTTGCCATGGCAGAAGGTTC TGGTGCGGGGCAATTCTTTACGCCAGGAAGCATTGTACGTCTTTTAGTGGAACTATTGGAACCTTATAAAGGAAGAATCT TTGACCCTGCCTGTGGTAGCGGCGGTATGTTCGTACAGTCATTGAAATTCATTAAGGAACACGGCGGCAATAAGAGCGAC ATCTCTATTTACGGTCAAGAAATGACGGCCCAAACCCTGCGTTTATGTTTAATGAACCTGTTGCTGCGCAATCTTTCTTT TGATATCAAATTGGGGAATTCTCTGTTAGATGATAAGTTCCCTGATTTAAAGGCCGATTTCGTAATCGCCAACCCTCCTT TTAATGTCAGCAATTGGCACCCTGAGGATCTGCCGGAAAACGACACCAGGCTTTTTGGCCCACGGGAAGAATTCACTACA GATGGCAGTGCCAATTATATGTGGATGCAAACTTTTTGGCACCATCTGAACGACAGGGGTACGGCTGGCGTTGTAATGGC CAATGGCGCCATGACCTCCAACACCAAAGGAGAAAAAAATGTACGGCAATATATGGTAGATAAGGGCATGATTGATTGTA TCGTTCGTATGCCCGATAAGCTTTTTTTGACCACTGGCATACCTGCCTGCTTGTTTATTCTTAGCAGAAATCGTGACGGT AAAGATGGCGAGCACCGTGAGCGCATGAACGAAATATTGTTTATAGATGCAGCAAAGATGGGTAAAATGGCCAGCCGTAA ACTACGGGTTTTTGAAGATGCCGATATTAAAAAAATTGCAGACGCCTATCATGCGTACCGAACGGTTCCCGAGGCTCTTG AAGGGCGCTCATTGGATCCCTACCAAGATGAGCTTGGCTTCTGTAAGGCAGCCACTGTAGAAGAAGTACAAAAGCAGGAT TATAAACTTACTCCTGGCATTTATGTGGGTACGGAGGCCGAAGAAGATGATGGCATCCCTTTTGAAGAAAAGATGGAAAC CTTAAAGGCTACTTTGTTGGCGCAGTTTGAAAAAGGAGAGAAATTGAAAAAACAAATAGTAGAGAATTTCGATAAATTTT AA Protein sequence : MAKADIDFEKELWDAANELRGAVSENNYKNYILPLVFLKHLSERFDIVKEELENTLNEPSSEYYTTNHEEKDYVLSDPDE YRSRNTFMIPKTASWQYLKDNAEQDDIKVKVDDAFDTIQDLLTAYNPQLNNLLPRIFVKSELSAKQTGGIINLLSHPKFS EKENPESDILGRIYEYYIGRFAMAEGSGAGQFFTPGSIVRLLVELLEPYKGRIFDPACGSGGMFVQSLKFIKEHGGNKSD ISIYGQEMTAQTLRLCLMNLLLRNLSFDIKLGNSLLDDKFPDLKADFVIANPPFNVSNWHPEDLPENDTRLFGPREEFTT DGSANYMWMQTFWHHLNDRGTAGVVMANGAMTSNTKGEKNVRQYMVDKGMIDCIVRMPDKLFLTTGIPACLFILSRNRDG KDGEHRERMNEILFIDAAKMGKMASRKLRVFEDADIKKIADAYHAYRTVPEALEGRSLDPYQDELGFCKAATVEEVQKQD YKLTPGIYVGTEAEEDDGIPFEEKMETLKATLLAQFEKGEKLKKQIVENFDKF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| hsdM | BAD24842.1 | HsdM protein | Not tested | Type-V SCCmec | Protein | 9e-97 | 41 |
| hsdM | BAH57701.1 | type I restriction-modification system DNA methylase | Not tested | Type-VII SCCmec | Protein | 1e-98 | 41 |
