Gene Information

Name : metB (zobellia_1454)
Accession : YP_004735898.1
Strain : Zobellia galactanivorans DsiJT
Genome accession: NC_015844
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 1729944 - 1731098 bp
Length : 1155 bp
Strand : -
Note : The Cystathionine gamma-synthase is found in the Selenoamino acid metabolism pathway and involved in the second step of the methionine biosynthesis; Uses a pyridoxal phosphate group as cofactor, attached to a lysine residue located in the central section

DNA sequence :
ATGGGCGAAAAAACGTTAAAATTCAACAGTAAGACAATACACGGAGGGCAGCAGCCAGACAAGGCCTATGGCGCCGTTAT
GCCTCCTATTTATCAAACATCTACCTATGCACAGACCACTCCTGGTGGACATAAGGGCTACGAGTATTCGCGAAGTGCCA
ACCCCACCCGAACGGCATTGGAGAATTCATTGGCCAGCATTGAGAATGGCACCTATGGTTTGGCCTTTGCAAGTGGCTTG
GCGGCTATTGATGCCGTTATAAAATTACTTGGCCCGGGTGATGAGGTGGTTTCAACAAACGACTTATACGGGGGAAGCTA
CCGATTGTTCAAACAGATATTCGAGAAATATGGCATAAAATTCAATTTTGTCGGCATGCAAGATACCGATACCATCGAAG
CGGCCATTACAGGAAATACGAAGTTGATATGGGTCGAGACCCCGACCAACCCTATGATGAATATTATAGATATTAAGGCG
GTGGCCGCAGTTGCCAAAAAACACAATGTGTTGTTAGCGGTAGATAATACATTTGCCACACCGTATTTGCAGACTCCCTT
GGATTTGGGGGCGGATATCGTTATGCATTCCGCGACCAAATATTTAGGCGGGCATAGCGATGTGGTCGCAGGGGCCTTGG
TCGTTAAGAACAAAGAACTGGCAGACCAACTTTATTTCATCCAGAATGCTAGTGGGGCGGTATGTGGACCTATGGATAGC
TTTTTGATTTTGAGAGGTATAAAAACATTGCATGTGCGTATGCAGCGCCATTGTGAGAACGGCGAAGCCGTTGCGCGATA
TTTGGAAAATCATCCCAAAATCGAAAAGGTGTATTGGCCCGGTTTTGAGAGCCACCCCAACCATGAAGTCGCCAAAAGTC
AAATGAACGGATACGGGGGCATGATTTCCTTTGTAACAAAGGGCAGTAGTTATGAGGAGGCTATAAAGATAGTTGAGCGG
CTTAAATTGTTCACCTTGGCCGAATCCTTGGGAGGGGTGGAGAGTTTGGCAGGACATCCGGCCAGTATGACCCATGCGAG
TATACCCAAAGAAGAACGGGAGAAGAGCGGGGTGGTCGATGCTTTGATCCGCTTGAGTGTGGGTATCGAAGATAAGGACG
ATTTGATAGCCGATTTGGAGCAGGCTATAGGATAA

Protein sequence :
MGEKTLKFNSKTIHGGQQPDKAYGAVMPPIYQTSTYAQTTPGGHKGYEYSRSANPTRTALENSLASIENGTYGLAFASGL
AAIDAVIKLLGPGDEVVSTNDLYGGSYRLFKQIFEKYGIKFNFVGMQDTDTIEAAITGNTKLIWVETPTNPMMNIIDIKA
VAAVAKKHNVLLAVDNTFATPYLQTPLDLGADIVMHSATKYLGGHSDVVAGALVVKNKELADQLYFIQNASGAVCGPMDS
FLILRGIKTLHVRMQRHCENGEAVARYLENHPKIEKVYWPGFESHPNHEVAKSQMNGYGGMISFVTKGSSYEEAIKIVER
LKLFTLAESLGGVESLAGHPASMTHASIPKEEREKSGVVDALIRLSVGIEDKDDLIADLEQAIG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-85 50
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-86 50
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 7e-64 45

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
metB YP_004735898.1 cystathionine gamma-synthase BAC0207 Protein 1e-70 46