Gene Information

Name : merA (TPY_3741)
Accession : YP_004721636.1
Strain : Sulfobacillus acidophilus TPY
Genome accession: NC_015757
Putative virulence/resistance : Resistance
Product : mercury(II) reductase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1249
EC number : -
Position : 3473036 - 3474670 bp
Length : 1635 bp
Strand : -
Note : -

DNA sequence : 
ATGGATATTCAGGGGATGACCTGTACGTCCTGCGAGCATCATGTCGGTCGCGCGCTCGAAAACGCGGGAGCGTCGGACAT
TCGGGTCAGTTTTCGCCGCGGACAAGCGGAATTTCAGGCCCCGCCGGATTTTTCGATCGAGAAGGCTCAGCAATTGATTG
TAGACGCCGGATATACACCGCAAGGGGTACGCATGACCGACGAAATGTCCCCCGAACGCGTGTCGTTCGGTTCAGCGGAC
TACGATCTGGTGGTGATAGGTTCGGGGAGTGCGGCGTTCGCGGCGGCCATTGAAGTGCGGGGCGCGGGAGCGAAGGTTTT
GATGATCGAGCGAGGAACCCTGGGCGGTACTTGCGTGAACGTCGGCTGTGTCCCCTCGAAGACCCTCTTAAAGGCTAGCG
AAATCCATCATATGGCTCTTCATCATCCATTTGCGGGGTTGCGGACCACGGCCTCTACACCTGATCTGGGCGAAGTGGTG
GCGGATAAAGACCGGTTGGTGGCCACCATGCGTCAGACCAAATATGCGGATTTGTTGGGGGAATATGATATCGAGTTCCT
CCAGGGGGAGGCTCGGTTTGTGGATTCCGCGCATCTTCGGGTCGGCGATCGCGTGATTCACGGCGGGCACTATCTCATTG
CCACCGGAGCGCGCCCGCGGATTCCCGATATTCCCGGCATCGATACGGTCAATTATTTGACCAGTACCACGGCACTGGAC
CTGACAACGATTCCCGAACACCTTATCGTGATTGGGAGTGGCTATATTGCGTTAGAGCTGGGTCAGATGTTTCGTCGTTG
GGGAAGCCATGTCACGTTCATTCAGCGCGGCCAAACCCTCTTGCCCGGTTATGACGCGGAAATCCGCCACGTGATGCAAG
AAGTGCTTGAAAATGAGGGGATTCGGGTCATGACCGGCGTGACCTATGAACGCGTGGAACAAAAGGGCTCGCAAAAAATC
GTTTATGTGACCCGAAACGGCGTCAGTGAGCGGATTATCGGGGATCAATTATTACTTGCGGCCGGTCGCGTCCCGAATAC
GGACGCGTTAGATTTGCCGGTAGCGGGCGTTGAACAGGGGGCTTTGGGGCAACCGATGGTCGATGGCACCTTAATGACCG
CCAATTCCCGGATTTACGCCGCCGGGGACGTCACTTTGGGTCCGCAATTTGTTTATGTGGCGGCGTACCAGGGCAAACTC
GCGGCGCAAAACGCTTTGGGATTACGGCCATCCCCGGCAACCGTCCGGTTGGATGTGGTTCCCGCGGTGACATTTACCCA
ACCGTCTTTAGCGACGGTCGGCATGACCGAAGAGCAGGCGAAGAGAGCCGGTCTTTCCGTGAAAACGGCGGTGTTGCCGT
TGGACGCGGTCCCTCGGGCATTAGCGAATCATGAGACTCGAGGCCTATTCAAAATGGTGGCCGAGGCGGAGTCCGGCCGA
ATTCTGGGAGTTCAGGCGGTCGCGGAAAATGCCGGCGACGTGATTTATGCCGCAACGTTGGCCGTGAAATTCGGGTTAAC
GATTGCGGACCTGACGGATACCTTAGCGCCCTACTTGACCATGGCGGAAGGACTGAAACTGACCGCCCTCACGTTTGATA
AAGATGTCTCGAAACTATCGTGTTGTGCGGGGTAG

Protein sequence : 
MDIQGMTCTSCEHHVGRALENAGASDIRVSFRRGQAEFQAPPDFSIEKAQQLIVDAGYTPQGVRMTDEMSPERVSFGSAD
YDLVVIGSGSAAFAAAIEVRGAGAKVLMIERGTLGGTCVNVGCVPSKTLLKASEIHHMALHHPFAGLRTTASTPDLGEVV
ADKDRLVATMRQTKYADLLGEYDIEFLQGEARFVDSAHLRVGDRVIHGGHYLIATGARPRIPDIPGIDTVNYLTSTTALD
LTTIPEHLIVIGSGYIALELGQMFRRWGSHVTFIQRGQTLLPGYDAEIRHVMQEVLENEGIRVMTGVTYERVEQKGSQKI
VYVTRNGVSERIIGDQLLLAAGRVPNTDALDLPVAGVEQGALGQPMVDGTLMTANSRIYAAGDVTLGPQFVYVAAYQGKL
AAQNALGLRPSPATVRLDVVPAVTFTQPSLATVGMTEEQAKRAGLSVKTAVLPLDAVPRALANHETRGLFKMVAEAESGR
ILGVQAVAENAGDVIYAATLAVKFGLTIADLTDTLAPYLTMAEGLKLTALTFDKDVSKLSCCAG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 6e-149 57
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 5e-149 57
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 2e-81 42
merA ABQ57371.1 MerA Not tested SGI1 Protein 1e-81 42
merA AGK07021.1 MerA Not tested SGI1 Protein 1e-81 42
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 1e-80 42
merA AGK07079.1 MerA Not tested SGI1 Protein 1e-81 42
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 5e-80 42
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 1e-80 42
merA AFG30120.1 MerA Not tested PAGI-2 Protein 2e-80 41
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 3e-80 41
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 2e-80 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
merA YP_004721636.1 mercury(II) reductase BAC0651 Protein 3e-149 57
merA YP_004721636.1 mercury(II) reductase BAC0224 Protein 2e-144 57
merA YP_004721636.1 mercury(II) reductase BAC0652 Protein 5e-81 42
merA YP_004721636.1 mercury(II) reductase BAC0653 Protein 4e-81 42