Gene Information

Name : Spica_0776 (Spica_0776)
Accession : YP_004697438.1
Strain : Treponema caldaria DSM 7334
Genome accession: NC_015732
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 856346 - 858145 bp
Length : 1800 bp
Strand : +
Note : -

DNA sequence :
ATGGCATTTGAACGAAACACCAGAATTATCTGTACCATGGGACCGGCAGTTCGCAGTGTGGATATGATCCGTTCTCTGAT
ACGCCGAGGCATGAATATGGCTCGGTTTAACTTTTCCCATGGGGATCACGAGTATCATGGGGAAGGGATCCATATGGTTC
GTGAAGCAGCTCGTTTGGAAGGGGTTCCAATAGCGCTTATTTTGGATACGAAGGGTCCCGAAATTCGAACCGGTCAGATA
CAAGATGGGGGAACCATAACACTTCAGAACGGGCAGTTTATCGAGGTGATTGCTGAAGTTGAGGCAAAGAACCGCTATGG
AGATCAAGGTCTTTTTACAACACCGGACCGGCTTACAGTTTCCTATGCTGATCTTGCCCAGGATGTTAAGCCAGGCGCCC
GAATATTGATTGCTGACGGCCTTTTTTCCCTCGATGTTGTTCAGGTGGATGGTCCCAGTATCCGTTGTAGGGTTACTAAT
GGGGGAGTCCTCGGAAGCCGAAAAAATGTGAATGTTATCGGTGTGCGAACCCGATTACCTGCCCTGTCAGAGCAAGATAA
GGCGGACATTTCATTTGGGGTTGAACAGGGGATGGATTTTATTGCCGCATCTTTTGTTCGGAAAGCCGCTGATGTAACGA
CCATTCACAAATATTTAGCAACCCTTAATTCGGATATACCTGTCATTGCAAAGATTGAAGATGAAGAGGGTCTTGAAAAT
ATCGAAGAAATAATACGGGTTTCTGCAGGTATTATGGTTGCCCGAGGCGATTTAGGTGTCCAGATTCCTACCGAACGGGT
GCCTCTCGAACAAAAACGTATCATCAGATTATGTAATCATGCTGGTAAGCCTGTCATTACCGCTACCCAGATGCTTGAAT
CGATGATTAAAAATCCCCGCCCTACCCGTGCTGAAGCAGGAGATGTGGCTAATGCAATTCTTGATGGTACCGATTGTGTT
ATGTTGTCAGGAGAAACCGCTAATGGCCAATTTCCCGAAGCTGCCGTTTCTGTAATGGATCAGATTGCCCGTACGGTGGA
AGCTTCTGATGAATATATACGATCTCTTGAAGAACGGCGTAATACTATTGCTACGAACGAAGATATCGCGGATGCCATCG
CCGATGCGTCTGCGCAGATTGCGGATCGTATTGGGGCGGTTGCTCTGGTAGTACCGACCCTACGGGGGAATACGGCCAAA
CTTATTAGTCGGCATCGTCCAAGACGCAAAATTATCGCCGCTACTCCAAGCGAGACGGTACAGCGGCGGCTTCTACTCCA
TTGGGGCGTGGTTCCAGTCAAGGTAGAACAGGAATCAGATTCCGAATCCATGATACAAAAGGCTATAAGCGCAGCCATTA
AAGAAGGTTTTGCAAAAAAAGCTGATAAGGTTGTGGTTGTTGCGGGTATTCCTCTTAATTCACCCCTTATGACCAACAGT
ATTCGGGTTCATGTAATCGGCAATATACTCGGTCGAGGACTTAATGGATTTGGAGGTCGTTGTACCGGTAGGATTGTGAA
GGCTCGGACTCTAGAGGATGCCGCCCTGGCGCTTCGGAAAAATGGCGGTGAAATTCTTCTTACCCACACTCTGGACGAAA
GTTTTATTCCCATACTTAGGGTTGTAGATGGGGTAATTCTCGAGGGAGTCTCTGAAATGCCCTGGGAAATGGTTAAGATA
ATCAATCCCAGCATCGTCTATGTTTCCCAAGTGCCCCAGGCTCTCGATCACTTCGAAGAGCATATCACGGTTACTCTGGA
TGGCTATGAGAAGCTTATCTATGAAGGGGCGCTTTTATAA

Protein sequence :
MAFERNTRIICTMGPAVRSVDMIRSLIRRGMNMARFNFSHGDHEYHGEGIHMVREAARLEGVPIALILDTKGPEIRTGQI
QDGGTITLQNGQFIEVIAEVEAKNRYGDQGLFTTPDRLTVSYADLAQDVKPGARILIADGLFSLDVVQVDGPSIRCRVTN
GGVLGSRKNVNVIGVRTRLPALSEQDKADISFGVEQGMDFIAASFVRKAADVTTIHKYLATLNSDIPVIAKIEDEEGLEN
IEEIIRVSAGIMVARGDLGVQIPTERVPLEQKRIIRLCNHAGKPVITATQMLESMIKNPRPTRAEAGDVANAILDGTDCV
MLSGETANGQFPEAAVSVMDQIARTVEASDEYIRSLEERRNTIATNEDIADAIADASAQIADRIGAVALVVPTLRGNTAK
LISRHRPRRKIIAATPSETVQRRLLLHWGVVPVKVEQESDSESMIQKAISAAIKEGFAKKADKVVVVAGIPLNSPLMTNS
IRVHVIGNILGRGLNGFGGRCTGRIVKARTLEDAALALRKNGGEILLTHTLDESFIPILRVVDGVILEGVSEMPWEMVKI
INPSIVYVSQVPQALDHFEEHITVTLDGYEKLIYEGALL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 1e-69 42
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 1e-69 42
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 4e-69 42
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 2e-69 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Spica_0776 YP_004697438.1 pyruvate kinase VFG0479 Protein 5e-70 42