Gene Information

Name : aldA (HYPMC_0549)
Accession : YP_004674359.1
Strain : Hyphomicrobium sp. MC1
Genome accession: NC_015717
Putative virulence/resistance : Virulence
Product : chloroacetaldehyde dehydrogenase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1012
EC number : 1.2.1.22
Position : 539885 - 541405 bp
Length : 1521 bp
Strand : +
Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15188393, 16926146, 9511738; Product type e : enzyme

DNA sequence :
ATGCAGCACGTAGCTATGGATAAGCTCAAAGGCCGGCAAATCATCAAGCCGCGCTATGACAATTTCATTGGTGGAAAGTG
GGTTGCGCCGGTGCGCGGCCAATACTTTTCCAACGTGACGCCGATTACCGGCCAGCAGGTTTGCGAGATCGCGCGTTCAA
CGGCGGAAGATATTGAACTGGCGCTCGACGCTGCGCACAAGGCGCGCGAATCCTGGGGCAATGCCTCGCCTGCCGAGCGC
GCCCGCGTACTGGCGAAAATCGCCAATCGGATGGAAGAAAATCTCGACGTCCTGGCGCTTGTCGAGACCATCGACAACGG
CAAGCCGATCCGCGAGACGACGCACGCCGACCTGCCGCTCGCGATCGATCACTTCCGCTATTTTGCGGGCTGTATCCGCG
CGCAGGAAGGTTCGATTGCCGAGATCGACCACGATACCGTCGCCTATCATTTCCATGAGCCGCTCGGCGTCGTCGGGCAG
ATCATTCCATGGAACTTCCCGCTTCTGATGGCAGTCTGGAAGCTGGCACCTGCGCTTGCCGCCGGTAACTGCGTCGTGCT
GAAGCCCGCCGAGCAGACGCCGATGTCGATCATGGTTCTGATGGACATCATCGGCGATATCCTGCCGGAAGGCGTCGTCA
ACGTCGTCAACGGTTTCGGTGTCGAAGCGGGTAAGCCGCTGGCGCAGAACAAGCGCATCGCCAAGATTGCCTTCACGGGC
GAGACGACGACGGGTCGCCTCATCATGCAGTACGCGTCGGAAAACATCATTCCGTGCACGCTGGAGCTGGGTGGCAAGTC
GCCGAACATCTTCTTCGCCGACGTGATGGATGCGGACGACGAGTACTTCGACAAGTGCCTCGAAGGCTTCACGATGTTCG
CGCTGAATCAGGGCGAAGTTTGCACCTGTCCGAGCCGTGCGCTGATCCAGCGCTCGATCTATGAGAAGTTCATGGAGCGG
GCTCTTGAGCGTGTCGTGAAGGTGAAGCAAGGTCATCCGATGGACGCTTCGACGATGATCGGTGCGCAAGCGTCCAACGA
TCAGCTCGAAAAGATCCTGAGCTACATCGAGATCGGCAAGGGCGAAGGCGCTCGCGTCCTGACGGGCGGCCGTCGTGCCA
ACCTCGGCGGTGAACTCGCGGGCGGCTACTATGTCGAGCCGACCGTGCTCGAAGGCCACAACAAGATGCGCGTCTTCCAG
GAGGAAATCTTCGGACCGGTCGTTTCCGTTACGACCTTCGAAGACGATGCGGAAGCGCTGGCGATCGCCAACGACACGCT
CTATGGCCTCGGCTCGGGCGTGTGGACCCGCAACGGTACGCGCGCGTATCGCATGGGCCGCGGTATCCAGGCTGGCCGCG
TCTGGACGAACTGCTATCACGCCTATCCGGCGCACGCTGCGTTCGGTGGCTACAAGCAGTCGGGCATCGGCCGCGAGACG
CACAAGATGATGCTCGATCATTATCAGCAGACGAAGAACATGCTCGTCAGCTATAGCCCGAAGGCGCTCGGCTTCTTCTG
A

Protein sequence :
MQHVAMDKLKGRQIIKPRYDNFIGGKWVAPVRGQYFSNVTPITGQQVCEIARSTAEDIELALDAAHKARESWGNASPAER
ARVLAKIANRMEENLDVLALVETIDNGKPIRETTHADLPLAIDHFRYFAGCIRAQEGSIAEIDHDTVAYHFHEPLGVVGQ
IIPWNFPLLMAVWKLAPALAAGNCVVLKPAEQTPMSIMVLMDIIGDILPEGVVNVVNGFGVEAGKPLAQNKRIAKIAFTG
ETTTGRLIMQYASENIIPCTLELGGKSPNIFFADVMDADDEYFDKCLEGFTMFALNQGEVCTCPSRALIQRSIYEKFMER
ALERVVKVKQGHPMDASTMIGAQASNDQLEKILSYIEIGKGEGARVLTGGRRANLGGELAGGYYVEPTVLEGHNKMRVFQ
EEIFGPVVSVTTFEDDAEALAIANDTLYGLGSGVWTRNGTRAYRMGRGIQAGRVWTNCYHAYPAHAAFGGYKQSGIGRET
HKMMLDHYQQTKNMLVSYSPKALGFF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
VC0819 NP_230467.2 aldehyde dehydrogenase Not tested VPI-1 Protein 4e-149 63
aldA AAC12273.1 aldehyde dehydrogenase Virulence VPI Protein 2e-154 62
aldA AAK20747.1 aldehyde dehydrogenase Virulence VPI Protein 2e-154 62
aldA AAK20776.1 aldehyde dehydrogenase Virulence VPI Protein 2e-154 62
aldA-1 YP_001216300.1 aldehyde dehydrogenase Not tested VPI-1 Protein 9e-154 62
ORF SG19 AAN62241.1 putative aldehyde dehydrogenase Not tested PAGI-3(SG) Protein 1e-65 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
aldA YP_004674359.1 chloroacetaldehyde dehydrogenase VFG0082 Protein 2e-149 63