Gene Information

Name : pyk (HMPREF0538_22005)
Accession : YP_004650502.1
Strain : Lactobacillus reuteri SD2112
Genome accession: NC_015697
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 2044305 - 2045726 bp
Length : 1422 bp
Strand : +
Note : COG: COG0469

DNA sequence : 
ATGAAGAAAACCAAGATTGTAAGTACACTTGGTCCTGCAAGTACTGATGTTGATACGATCGTTAAGTTGATCAATGCGGG
AGCTAACATTTTCCGTTTCAACTTCTCACACGGTGACCACCCAGAACACTTGGGTCGGATCGAAAACGTACACAAGGCTG
AAGAAATTACTGGCAAGCACGTTGGTCTTATGCTTGATACTAAGGGTGCCGAAATTCGGACTACTGTTCAAAAAGAAGGT
AAGATCAACTTTGAAATTGGCGACAAGGTTCGCATTTCAATGGATCCTTCAATTGAAGGTACTCATGACAAGATTGCTGT
TACCTACCCAGGCTTATACGATGATACTCATGTTGGTGGCCATGTTCTTTTTGATGATGGTTTAATTGACATGGTTATTG
ATGAAAAAGACGATGCAAACAAGGAACTTGTATGTCACGTCTTAAACCATGGTGTTCTTGGTTCTCGGAAGGGTGTTAAC
GCCCCTGGTGTATCAATCAACTTACCAGGTATTACTGAAAAGGACAGTAGCGATATTCGTTTTGGTTTGGAAAACAAGAT
CAACTACATTGCTGCATCCTTCGTTCGTAAGGCTCAAGATGTTCTTGACATTCGCGAATTACTTAAGGAAAAGAACATGG
AAGATGTTCAAATTTTCCCTAAGATTGAATCTCAAGAAGGTATCGACAACTTTGAAGAAATCATTGCTGTTTCTGACGGT
TTAATGGTACCTCGTGGTGACATGGGTGTTGAAATTCCTGCCCAAAATGTGCCAATTGTTCAAAAGCACATGATCAAGCG
TTGTAACGAATTAGGTAAGCCAGTTATTACTGCTACCCAAATGCTTGACTCAATGCAAGAAAACCCACGTCCAACCCGTG
CCGAAGTATCAGACGTTGCTAACGCCGTATTTGACGGTACTGATGCTACTATGCTTTCTGGTGAAAGTGCTAACGGTGAC
TACCCAGTTGAATCTGTTGCAATGATGAACGACATTGACATTAAGGCTGAAAACCACCTTTGGGAATTCGGTACTGAAAA
GTTCGATTGGGACAAGTCTGACGTAACTGAAACTATCGGTTCTGCTGTTGCTAACGCAGCTAAAGACTTAGACATTCACA
CAATTGTTGCTTACACTGCTTCAGGCTACACTGCTAAGATGATTTCTAAGTACCGTCCTAATGCTGATATCGTTGCATTA
ACTCCAAACGAACGTGTAGAACGTGGACTTATGATCAACTGGGGTGTTCAACCATACGTTGTTGATGAAATGAAGAACAC
TGATACAATGTTCGACTTAGCTGCTAAGAAGGCTGTTGAACTTGGCTTTGCTAAGAAGGGCGACAGGATCATCATCGTTG
CTGGTGTTCCTTTGGGTGTACCAGGTGCAACTAACATGATGCGTGTTAAGACTATCGACTAA

Protein sequence : 
MKKTKIVSTLGPASTDVDTIVKLINAGANIFRFNFSHGDHPEHLGRIENVHKAEEITGKHVGLMLDTKGAEIRTTVQKEG
KINFEIGDKVRISMDPSIEGTHDKIAVTYPGLYDDTHVGGHVLFDDGLIDMVIDEKDDANKELVCHVLNHGVLGSRKGVN
APGVSINLPGITEKDSSDIRFGLENKINYIAASFVRKAQDVLDIRELLKEKNMEDVQIFPKIESQEGIDNFEEIIAVSDG
LMVPRGDMGVEIPAQNVPIVQKHMIKRCNELGKPVITATQMLDSMQENPRPTRAEVSDVANAVFDGTDATMLSGESANGD
YPVESVAMMNDIDIKAENHLWEFGTEKFDWDKSDVTETIGSAVANAAKDLDIHTIVAYTASGYTAKMISKYRPNADIVAL
TPNERVERGLMINWGVQPYVVDEMKNTDTMFDLAAKKAVELGFAKKGDRIIIVAGVPLGVPGATNMMRVKTID

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 2e-93 46
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 2e-93 46
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 5e-93 46
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 5e-93 46

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pyk YP_004650502.1 pyruvate kinase VFG0479 Protein 8e-94 46