Gene Information

Name : metC (HMPREF0538_21498)
Accession : YP_004649997.1
Strain : Lactobacillus reuteri SD2112
Genome accession: NC_015697
Putative virulence/resistance : Resistance
Product : cystathionine beta-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.8
Position : 1523051 - 1524193 bp
Length : 1143 bp
Strand : +
Note : COG: COG0626

DNA sequence : 
ATGAAATTCAATACACAATTAATTCATGGCGGTAATAGTGAAGATCCAACCACTGGTGCGGTTTCAACACCGATTTACCG
TTCATCAACATTCCATCAACATGTTCTTGGCGGTGAACCTAAATGGGAATATTCTCGAACAGGAAATCCAACACGTGCAT
CTCTTGAAAAATTAATCGCAGAGCTTGAACATGGGACAGCCGGCTTTGCATTTGCTTCTGGATCTGCTGCTATTCATGCT
ACTTTTTCTTTATTCTCTCAAGGCGATCATTTTGTAGTTGGTAGTGATGTATACGGGGGAACATTCCGGTTAATCAACAA
GGTATTAAAACGCTTTGGCCTTGAATTTACTGTTGTTGACATGCAAGACCTTGAAGCAGTCGAAAATGCAATTCAAGATA
ATACCGTTGCAGTTTATTTTGAAACGCCAACTAATCCGCTCTTGCAAATCGCTGATATTAAAGCAATTGCTGATATCGCA
AAAAAGCATGGAATAAAGACAATTGTTGATAATACCTTTGCTACCCCTTATAACCAACAACCGTTAACTCTTGGGGCAGA
TATTGTTGTTCACTCCGCAACCAAATATTTAGGCGGTCATAGTGATGTTGTTGCCGGATTAGCAGTTACTAACGATGATG
AGATTGCTGAACAATTAGCATTCCTGCAAAACTCAATCGGTAGTACACTTGGCCCTGATGATAGTTGGCTATTACAACGG
GGAATGAAAACTCTCGGTGCGCGGATGCGAGCTCACCAAGAAAATGCGAATGAAGTTATTAATTTCCTCCAAAACGATGA
CCATATTGGAAAAATTTATTATCCAGGCTTAAAAGATTTTCCTGGTCATGAGATTGCGGCTAAGCAAATGCGGAACTTTG
GAGCAATGATCTCCTTTGAACTTAAGGATAGTTTAGATGCGAAGAAGTTTGTTGAAAGTCTACAATTAATTGATCTTGCG
GAAAGTTTGGGAGGAATTGAAAGCTTGATTGAAGTTCCAGCTGTCATGACCCATGGATCTATTCCCCGGGAAATAAGATT
AGAAAACGGAATTAAAGATGAGTTGATTCGTCTTTCAGTGGGAATTGAGGACCCTGAAGATATTATTGCTGACTTGCAAC
AAGCACTTAAAAAATTAGATTAA

Protein sequence : 
MKFNTQLIHGGNSEDPTTGAVSTPIYRSSTFHQHVLGGEPKWEYSRTGNPTRASLEKLIAELEHGTAGFAFASGSAAIHA
TFSLFSQGDHFVVGSDVYGGTFRLINKVLKRFGLEFTVVDMQDLEAVENAIQDNTVAVYFETPTNPLLQIADIKAIADIA
KKHGIKTIVDNTFATPYNQQPLTLGADIVVHSATKYLGGHSDVVAGLAVTNDDEIAEQLAFLQNSIGSTLGPDDSWLLQR
GMKTLGARMRAHQENANEVINFLQNDDHIGKIYYPGLKDFPGHEIAAKQMRNFGAMISFELKDSLDAKKFVESLQLIDLA
ESLGGIESLIEVPAVMTHGSIPREIRLENGIKDELIRLSVGIEDPEDIIADLQQALKKLD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 5e-80 52
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 4e-81 52
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 9e-67 46

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
metC YP_004649997.1 cystathionine beta-lyase BAC0207 Protein 2e-62 45